Enzymatic degradation and transport of endothiopeptides into Escherichia coli K12 mutant strains
Authors: Nowak-jary, J., Andruszkiewicz, R., Payne, JW.,
Year of publication:2008
Journal: Fems Microbiology Letters, , Volume: 285(2), Pages: 291-297.
Publisher: Blackwell Publishing; 9600 Garsington Rd
Transport of three synthesized endothiopeptides: Ala Psi[CSNH]Ala, Ala Psi[CSNH]Leu, and Ala Psi[CSNH]Phe, into Escherichia coli K12 mutant strains and enzymatic degradation studies were carried out. These compounds, well transported by permeases, but significantly more resistant to enzymatic cleavage than the corresponding natural peptides, seem to be useful as enzyme inhibitor carriers.