Staff Profile of Aamer Sandoo

Name
Dr Aamer Sandoo
Position
Lecturer in Cardiovascular Physiology
Email
a.sandoo@bangor.ac.uk
Phone
3486
Location
George Building, Normal Site

Background

Dr Aamer Sandoo is a Cardiovascular Physiologist specialising in clinical research involving patients with autoimmune disease, breast cancer and cardiovascular disease.  Aamer, whose background is in cardiac rehabilitation, has spent ten years managing several large clinical research projects in the NHS providing him with extensive experience in outpatient clinical research.  Aamer also has considerable expertise in using several non-invasive assessments of blood vessel function including assessment of microvascular perfusion using drug iontophoresis, flow-mediated dilatation, pulse-wave analysis, and carotid ultrasound.  Since joining Bangor University in 2014, Aamer was responsible for equipping the Schools Cardiovascular Laboratory with a state-of-the-art laser Doppler imaging scanner, high-resolution ultrasound scanner, and specialist software to measure blood vessel health.  

Research Focus

Since completing his PhD in 2010, Aamer has rigorously examined the reasons why some patients with rheumatoid arthritis develop cardiovascular disease, and as such, has published several key papers in this area.  Aamer has a well-established collaboration with Dr Yasmeen Ahmad from the Peter Maddision Rheumatology Centre, Betsi Cadwaladr University Health Board (BCUHB), and Prof. George Kitas from the Dudley Group NHS Foundation Trust, Dudley.  Of particular note, Aamer is one of the original members of the ATTAC-RA consortium – an international group tasked with developing an RA-specific cardiovascular risk calculator suitable for use in many countries (http://atacc-ra.com/about-atacc-ra/).  Aamer is also interested in the effects of breast cancer medications on blood vessel health and works closely with Dr Catherine Bale from the North Wales Oncology services, BCUHB.  Aamer’s research also examines arterial health in aging populations, and he is currently piloting studies which aim to examine the impact of dietary supplements on blood vessel function.  

Research Impact

Aamer’s research projects have yielded numerous publications including original articles, editorials, invited systematic reviews, narrative reviews, research letters and case studies in high-impact factor, peer-reviewed journals of international standard (36 publications, 20 as first author, 900 citations) as well as publication of 18 conference proceedings at national and international conferences including several oral presentations.  Aamer has recently been invited by Elsevier Publishing group to complete two book chapters in collaboration with an international team of clinicians and scientists on Cardiac Involvement in Autoimmune, Rheumatologic and Inflammatory Conditions. Aamer is also an invited reviewer for 18 internationally recognised journals, and 2 funding bodies.  In addition, Aamer also teaches students on the MSc Rheumatology course in Kings College London.  These achievements represent his growing scientific profile in clinical cardiovascular physiology. 

External Research Funding

  • Sandoo A, Moore JP, Ahmad Y. 2016.  Project grant for project entitled “The Effects of Dietary Nitrate Supplementation on Improving Blood Vessel Function in Patients with Rheumatoid Arthritis”.  Blue Sky Charity Funding. £67,955
  • Sandoo A, Rouse P, Kitas GD. 2013. Education Grant for the Development of a Physical Activity Educational Tool for Rheumatology Healthcare Professionals. The Dudley Group NHS Foundation Trust. £15,000

Research Studentships and Supervision 

2015 - Aamer was awarded a School funded studentship to recruit a PhD student onto a project examining cardiovascular disease in rheumatoid arthritis. This studentship was awarded to Emily-Louise Hogarth (PhD in Clinical Cardiovascular Physiology).

Emily will be investigating the impact of diet on vascular health in patient populations at increased risk for cardiovascular disease.  Her expected completion date is March 2019.

Other Current Research Students:

  • Emily Dunn and Danial Tomos Jones (MRes in Applied Sport and Exercise Physiology) - Emily Dunn and Danial Jones will be examining the impact of diet on vascular health in older individuals and will help develop laboratory methods to characterise the effects of oral bacteria on vascular health.  Their expected completion date is September 2017.

  • Donato Giuseppe Leo (MSc in Exercise Rehabilitation) - Donato is completing a Masters project examining the post activation potentiation phenomena which occurs following a maximal voluntary contraction.  His expected completion date is September 2016.

Professional Qualifications

  • PhD Cardiovascular Physiology (University of Birmingham)
  • MSc Cardiac Rehabilitation (University of Essex)
  • BSc Sport and Exercise Science (Coventry University)
  • Immediate Life Support Certification (Dudley Group NHS Foundation Trust)
  • Phlebotomy and Cannulation (Dudley Group NHS Foundation Trust)
  • BACPR Phase IV Clinical Exercise Instructor including 180 hours of exercise supervision in clinical populations (British Association of Cardiac Rehabilitation)
  • Advanced Motorcycle Rider – Gold Award (Royal Society for the Prevention of Accidents)

Teaching

  • Director of Student Engagement
  • Course Representative Lead
  • JXH1028 – Physical Activity and Health (First year undergraduate module)
  • JXH2024 – Sport and Exercise Physiology (Second year undergraduate module)
  • JXH4001 – Exercise is Medicine (Masters module)

Membership of professional organisations  

  • The Physiological Society (Affiliate member)
  • British Association for Cardiovascular Prevention and Rehabilitation
  • School Science Ambassador (Science, Technology, Engineering and Mathematics Network)

Selected Publications

Please visit the publications page of Dr Aamer Sandoo to view recent publications.

Selected Conference Presentations

  • Sandoo A, Lahart I, Kitas GD, Carmichael A. Microvascular endothelial dysfunction is evident in patients with HER2 positive breast cancer who are newly treated with Herceptin. Proc Physiol Soc. 2015; 34: C35  
  • Dimitroulas T, Sandoo A, Toms TE, Veldhuijzen van Zanten JJCS, Smith JP, Kitas GD. Clinical remission following treatment with tumour necrosis factor-alpha antagonists is not accompanied by changes in asymmetric dimethylarginine in patients with rheumatoid arthritis. Annals of Rheumatic Diseases. 2012; 71(3): 662.
  • Panoulas VF, Toms TE, Metsios GS, Stavropoulas-Kalinoglou A, Sandoo A, Douglas KMJ, Kitas GD. QT Prolongation associates with increased mortality in patients with rheumatoid arthritis. Heart. 2012; 98(1): A36
  • Panoulas V, Toms T, Douglas KMJ, Sandoo A, Kitas G. Prolonged QTc and systemic inflammation: A deadly interplay in patients with rheumatoid arthritis. European Heart Journal. 2012; 33(1059): 0195-668X.
  • Sandoo A, Smith JP, Kitas GD. Predictors of subendocardial viability ratio in patients with rheumatoid arthritis: the role of inflammation and classical cardiovascular disease risk factors. Rheumatology. 2012; 51(3): iii79.
  • Sandoo A, Veldhuijzen van Zanten JJCS, Toms TE, Carroll D, Kitas GD.  Anti-TNF therapy transiently improves high density lipoprotein levels and microvascular endothelial function in patients with rheumatoid arthritis: a longitudinal study. Rheumatology. 2012; 51(3): iii78.
  • Toms T, Sandoo A, Smith JP, Cadman S, Nightingale P, Kitas GD. The effect of anti-inflammatory therapy on lipid sub-fractions and vascular function in rheumatoid arthritis: a prospective study. Rheumatology. 2012; 51(3): iii80.
  • Dimitroulas T, Sandoo A, Jet JJCS Veldhuijzen van Zanten, Smith J, Metsios G, Nightingale P, Stavropoulos-Kalinoglou A, Kitas GD. Predictors of assymetric dimethylarginine in rheumatoid arthritis. Arthritis and Rheumatism. 2011; 63(10): S827.
  • Sandoo A, Carroll D, Kitas GD, Veldhuijzen van Zanten JJCS. Microvascular and macrovascular endothelial function are independent of each other in patients with rheumatoid arthritis. Annals of Rheumatic Diseases. 2010; 69(3): 109.
  • Toms T, Blackmore H, Sandoo A, Smith JP, Vallance D, Stavropoulos-Kalinoglou A, Veldhuijzen van Zanten JJCS, Kitas GD. The oxidative susceptibility of low-density lipoprotein in rheumatoid arthritis: the impact of drug therapy. Annals of Rheumatic Diseases. 2010; 69(3): 520.
  • Metsios GS, Stavropoulos-Kalinoglou A, Sandoo A, Toms T, Smith J, Koutedakis Y, Kitas GD. Is there an association between rheumatoid cachexia and cardiovascular disease? Annals of Rheumatic Diseases. 2010; 69(3): 514
  • Sandoo A, Veldhuijzen van Zanten JJCS, Carroll D, Toms TE, Kitas GD. Endothelial function associated with classical cardiovascular disease risk but not disease-related inflammation in rheumatoid arthritis. Rheumatology. 2010; 49(1): i156.
  • Gasparyan AY, Sandoo A, Stavropolous-Kalinoglou A, Kitas GD. Mean platelet volume in patients with rheumatoid arthritis: the effect of anti-TNF therapy. Rheumatology. 2010; 49(1): i100.
  • Sandoo A, Veldhuijzen van Zanten JJCS, Smith JP, Metsios GS, Stavropoulos-Kalinoglou A, Carroll D, Kitas GD. The effects of a reduction in disease activity on microvascular Function, macrovascular function and arterial stiffness in patients with rheumatoid arthritis. Rheumatology. 2009; 48: i163 - i168.
  • Sandoo A, Veldhuijzen van Zanten JJCS, Smith JP, Carroll D, Kitas GD. Arterial stiffness, micro- and macro-vascular endothelial function not associated with inflammation in patients with rheumatoid arthritis. Microcirculation. 2009: 16(5): 444-486.   
  • Metsios GS, Stavropoulos-Kalinoglou A, Sandoo A, Nevill AM, Koutedakis Y, Kitas GD. Rheumatoid cachexia, physical activity and cardiovascular risk. 17th International Congress on Physical Education & Sport, Komotini, Greece. Conference Proceedings. 2009; Abstract No: 3766
  • Stamatelopoulos KS, Kitas GD, Papamichael CM, Chryssohoou E, Kyrkou K, Georgiopoulos G, Protogerou A, Panoulas VF, Sandoo A, Tentolouris N, Mavrikakis M, Sfikakis PP. Preclinical atherosclerosis is of similar severity in rheumatoid arthritis and diabetes mellitus despite differential impact of traditional risk factors and systemic inflammation. Arthritis and Rheumatism. 2009; 60 (10): 941.
  • Price MJ, Thake D, Sandoo A. The effects of sodium bicarbonate ingestion on repeated sprint performance. Journal of Sports Sciences. 2005; 23(2): 64. 93-223

Peer Reviews

Annals of Rheumatic Diseases (IF: 9.082); Arthritis Care & Research (IF: 4.75); Rheumatology (IF: 4.172); International Journal of Rheumatic Diseases (IF: 1.65); Psychonueroendocrinology (IF: 5.168); PLoS ONE (IF: 4.411); The Journal of Rheumatology (IF: 3.7); Scandinavian Journal of Rheumatology (IF: 2.379); Pharmacological Research (IF: 4.408); Clinical Interventions in Aging (IF: 2.083); Heart and Vessels (IF: 2.126); Journal of Diabetes and Metabolism (3.38); ecancer (IF: n/a); Breast Cancer: Targets and Therapy; Onco Targets and Therapy (IF: 2.073); General Medicine: Open Access (IF: n/a); Clinical and Experimental Rheumatology (IF: 2.973); Therapeutics and Clinical Risk Management (IF: 1.343); Research for Patient Benefit (charitable funding body); Rheumafonds (charitable funding body)

Awards and Prizes

  • Siemens Ron Grimley Award for best international paper – £500, The Dudley Group NHS Foundation Trust, 2012
  • Travel Bursary for oral conference presentation, European League against Rheumatism, Rome, Italy, 2010
  • Siemens Ron Grimley Award for best research project – £500, The Dudley Group NHS Foundation Trust, 2010
  • PhD Scholarship, School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham

Hobbies and Interests

Aamer has a wide and varied interest in Sport.  As a former Amateur Boxer, Aamer competed in 12 bouts as a lightweight with 10 wins and 2 losses.  He is also an active 10k runner, hiker and weightlifter.  Aamer regularly rides a superbike (Suzuki GSX-R 1000) on race tracks and on some of the most technical roads in England and Wales.  He completed his RoSPA advanced rider test in August 2014 achieving a Gold - the highest civilian rating possible.  Aamer has also trekked up Scafell Pike (978m), Mount Snowdon (via Crib Goch) (1085m), Mount Smolikas, Greece (2,637m) and completed several other well-known hikes. 

Links

Twitter: https://twitter.com/draamersandoo

YouTube: https://www.youtube.com/channel/UCxfslQe8hBQ3fSrC31HcZDw

Video Methods Article: http://www.jove.com/video/52339/a-methodological-approach-to-non-invasive-assessments-vascular

Google Scholar: https://scholar.google.co.uk/citations?user=5IRCnz4AAAAJ&hl=en