Staff Profile of Hans-Peter Kubis

Image of Hans Peter Kubis
Name
Hans-Peter Kubis
Position
Senior Lecturer
Email
h.kubis@bangor.ac.uk
Phone
(01248) 38 8261
Location
Padarn Building, Normal Site

Video Profile

View a video profile here

Professional Qualifications:

Dipl. Biol. (Biological Sciences); Dr. rer. nat. (Biochemistry); P.D. (venia legendi, Physiology).

Honours:

PD: Privat Dozent (Habilitation)

Research Areas:

Hans-Peter Kubis is Director of the Health Exercise and Rehabilitation group. His main research area is the prevention and treatment of obesity, as well as its underlying causes and mechanisms on physiological and psychological levels. This includes the development of weight loss strategies, techniques for investigating perceptual responses to food, analysing the interaction of nutrients and metabolism on whole body and cellular levels. Moreover, he investigates the pathophysiology of chronic diseases connected with obesity like obstructive sleep apnoea and diabetes type II. A further main interest is the investigation of mechanisms of adaptations to exercise on psychological, physiological and cellular levels. In particular, interactions of exercise stimuli and nutrients influencing skeletal muscle and whole body metabolism and weight regulation are investigated with various techniques (see paragraphs about particular PhD projects below). A broad spectrum of physiological, cellular-biochemical, as well as psychological techniques are used for the investigations (for more details, please see publication list).

Current (*) and recent (**) PhD projects: 

  • Exercise participation in our society is low contributing to high incidence of chronic diseases. Often, people, who do not exercising, address lack of enjoyment as a reason for sedentarism. In this PhD project, we investigate whether people with various levels of physical activity perceive exercise as a reward. For our investigation, we are using a discounting paradigm to establish the exercise reward value and compare it with the discounting of money and food rewards. In further studies, we try to manipulate the reward perception of exercise of individuals and assess perceptual responses to exercise. (PhD student Tamam Albelwi*) 
  • Obesity is a worldwide growing problem; in this PhD project, we are investigating perceptual responses to food using a novel phone application. It was recently hypothesized, that obese individuals would have a greater drive towards food, as well as having a more frequent and intensified wanting. Moreover, it has been suggested that individuals with obesity have an altered reward response to food; they would like food different to lean people. Using our phone application, we measure perceptual responses to food of people with and without obesity in their personal environment over longer time periods to increase understanding and possible treatment of overeating. (PhD student Kholoud Alabduljader**) 
  • Exercise is often prescribed for weight loss purposes; however, often people achieve less than expected and some even gain weight. In this PhD project we are investigating the influence of appetite hormones for the weight response to exercise training. It is assumed that some appetite hormones levels will be able to explain some of the variability of weight change after exercise training. Understanding the contribution of appetite hormone responses during exercise training will help to support participants in their efforts to control their weight. (PhD student Fardin Fatahi**) 
  • Weight loss interventions, like typical diets, lead only to transient weight loss and often people even regain more weight after taking part in diet interventions. In this PhD, we developed a new weight loss intervention based on multiple behavioural and nutritional guidelines, which are shown to be important for maintaining a healthy weight. A novel approach based on behavioural theories was developed for maximizing independence of participants in their effort to lose weight. A system of behavioural commandments for reflective work on eating behaviour was developed and the intervention was tested on different population groups. (PhD student Mishal Alshubrami**)  
  • People train for improvement of cardiovascular fitness; however, unfortunately, some people do not improve their fitness level quickly, or even fail to achieve any improvement at all. In this PhD sedentary people are trained and their training responses analysed on various physiological levels, including body composition, VO2max, metabolic blood markers and hormones. It is aimed to understand more about the reasons of a failed adaptation to exercise training and look for crucial factors predicting responders and non-responders towards exercise training. Understanding underlying mechanisms, which might counteract training responses, will help people to avoid stimuli that could suppress training responses. (PhD student Matthew Jackson**) 
  • Obstructive sleep apnoea (OSA) is a sleep disorder, which results in a disrupted sleep pattern caused by periods of impaired breathing due to obstruction of the upper airways. Muscles of the upper airways in people affected by OSA tend to relax too much during sleep; this contributes to the occlusion of airways. People who suffer from this disease have an elevated cardiovascular risk, and often reveal concentration difficulties and feel mentally as well as physically fatigued. Formerly, it was found that patients with OSA perceive respiratory work differently to healthy people in wakefulness. Reasons for this alteration could be caused by muscular but also central nervous system changes. In this PhD project, we investigate the effort perception and muscular activity of obstructive sleep apnoea and healthy people during resisted breathing and exercise of limb muscles for a greater understanding of mechanisms in OSA. (PhD student Claire Griffith-Mcgeever*) 
  • The severity of Obstructive sleep apnoea (OSA) is characterised by the number of incidences of reduced and interrupted breathing during sleep, expressed as apnoea hypopnoea index (AHI). OSA patients are reported to have and reduced respiratory drive during sleep and alterations in blood born factors known to influence the respiratory systems regulation. In this PhD project, we investigated the association of respiratory sensitivity to carbon dioxide and oxygen, as well as blood born factors known to influence breathing, and autonomic systems regulation with the AHI in OSA patients. Gaining more information about the factors mediating the severity of OSA will improve treatment for OSA patients, which can be developed in the future. (PhD student Christopher Earing**) 
  • High sugar intake is connected to obesity. In this PhD we investigated the connection of sugar availability with alterations in muscle and whole body metabolism which are known to be typical for obese, sedentary individuals. Diet-exercise interventions as well as cell culture experiments based on muscle biopsies are employed to investigate crucial factors in metabolic regulation related to sugar availability. Carbohydrate response element binding proteins (ChRBP), which can sense glucose, are strong mediators of anaerobic metabolism but also linked to suppressor molecules of aerobic metabolism. We investigated their involvement in metabolic regulation of skeletal muscle connected to sugar intake. (PhD student Francesco Sartor**)

External PhD students (current(*) and recent (**):

 

  • Yael Pernick* (Israel, Assaf Harofe Medical Center): Cardiac exercise rehabilitation with high and low training intensity [Collaboration with Dr Jonathan Moore] 
  • Timothy Davies* (Bangor, Department of Psychology): Contribution of foraging behavioural strategies for eating behaviour of participants with various BMI [Collaboration with Prof Robert Rogers] 
  • Nina Hanke** (Germany, Medical School Hanover): Investigation of the influence of glucose on metabolic transformation in primary muscle cells. [Collaboration with Prof Gerolf Gros] 
  • Michael Scholz** (Germany, Medical School Hanover): Contribution of AKT Ras pathway interaction for development of muscle cells and expression of myosin heavy chains isoforms. [Collaboration with Prof Gerolf Gros]

Collaborations (current and recent):

Dr Damian McKeon and Dr Christopher Earing, BCUHB, Ysbyty Gwynedd, Pulmonary department; Marion Cliffe, BCUHB, YSbyty Gwynedd; Prof. Robert Rogers, Department of Psychology, Bangor; Dr Francesco Sartor, Philips Healthcare, Netherlands; Prof Gerolf Gros, Dr Joachim Meissner, and Prof Theresia Kraft, Medical School Hannover, Department of Physiology, Germany; Prof Stefan Engeli, Medical School Hannover, Department of Clinical Pharmacology, Germany; Prof Martin Leuwer, Medical School Liverpool; Dr Juergen Mueller, Cancer Research Institute, Bangor; NovoNordisk, Danmark; Prof Dan Ayer, Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah; Dr David Markland, Dr Aamer Sandoo, Dr Jonathan Moore, School of Sport, Health and Exercise Sciences;

 

Funding:                 

 

Grants:

 

2016 BCUHB – Small Grant Scheme (Earing, McKeon, Owen, Kubis): Pathophysiology of OSA – £3,880 

2012 NISCHR: Dr Tom O’Brien, Prof Jane Noyes, Dr Hans-Peter Kubis: Wellbeing, health and fitness of children with mobility impairments (Well MI); Scoping and development of ‘keep-fit’ interventions – £20, 000 

2011 Friends of Ysbyty Gwynedd: Request for financial support for the investigation of mechanisms and treatment of Obstructive Sleep Apnea – equipment grant; Damian McKeon, Hans-Peter Kubis, Christopher Earing, Jonathan Moore – £22,000 

2010 BCUHB Small Grants Scheme: Factors mediating the severity of symptoms in Obstructive Sleep Apnea (OSA); Damian McKeon, Hans-Peter Kubis, Christopher Earing – £14,000 

2007 Hans-Peter Kubis, Dr. Andrew Lemmey, Prof. Peter Maddison, North Wales Trust Research Grant – £5,000  

2007 North West Wales NHS Trust:.Muscle quality in rheumatoid arthritis patients – mechanism of muscle loss.  Dr. Jeanette Thom, Dr.Verena Matschke, Dr. Kubis, Dr Lemmey - £8,446 

2006-2009 David Edward Memorial Scholarship: PhD-Studentship, H.P. Kubis and J. Thom – £42,000  

2003 – 2005 Gros GR489/13-3 DFG: In-vitro investigation of muscle plasticity. – 165,000 Euro 

1999 – 2000 HILF-Fond, Kubis BA 2017: Isolation and characterisation of membrane bound carbonic anhydrase in human heart – 47,000 DM 

1998 – 2002 Gros GR489/13 DFG: Muscle Plasticity – 325,000 DM

  

PhD Studentships:

 

2015 PhD Studentship – Coleg Cymraeg Wales: Claire Griffith-Mcgeever – £55,000

2014 PhD Studentship – Saudi Arabia: Tamam Albelwi – £90,000

2011 PhD Studentship – Iran: Fardin Fatahi – £65,000

2011 PhD Studentship – Kuwait: Kholoud Alabduljader – £65,000  

2011 PhD Studentship – Saudi Arabia: Mishal Alshubrami – £65,000  

2010 PhD Studentship 125 years Bangor University: Christopher Earing – £45,000 

2009 PhD Studentship 125 years Bangor University: Matthew Jackson – £45,000 

2007 PhD Studentship – Saudi Arabia: Hajed Al-Otaibi – £42,000  

2005 PhD Studentship - David Edward Memorial Scholarship: Francesco Sartor – £47,000

Research Opportunities:

Hans is always looking for people who are excited about research and want to learn and experience research at first hand. My research activities are dedicated to the problem of obesity and uses a broad spectrum of techniques and experimental designs (see PhD student list and references). Students who want to work on an MSc, MRes, or PhD with our group or me should contact me under pes203@Bangor.ac.uk.  I nternational students who want to do their PhD or MSc/MRes with me are very much welcome!

Links:

Research gate: https://www.researchgate.net/profile/Hans-Peter_Kubis

Google scholar: https://scholar.google.co.uk/citations?user=2JglGUIAAAAJ&hl=en

 

Selected Publications:

Please visit the publications page of Dr Hans-Peter Kubis to view recent publications.

Keynote and Invited Addresses:

Invited Address at the Pharmacology Meeting of the University of Vienna.  2001.
Invited Address at the German Physiological Society Meeting.  Hannover, 2007.

External Reviewing:


Invited reviewer: MRC, BBSRC, Wellcome Trust.