Gwybodaeth Cyswllt
Martina Lahmann is working at the Organic Chemistry/Life Science interface (Chemical Biology). Her expertise is in organic synthesis, carbohydrate and glycoconjugate chemistry.
Martina received her diploma in Chemistry at the University of Hamburg, Germany, in 1994. She continued her work in the group of Prof. Joachim Thiem and obtained her Ph.D. in Organic Chemistry in 1997. Thereafter she moved to Stockholm University, Sweden, to work as a postdoc with Prof. Per J. Garegg and Prof. Stefan Oscarson. In 2002 she moved to Göteborg University, Sweden, to supervise the part of Stefan’s group which was relocated to Göteborg University, to lecture Organic Chemistry, and then to develop her independent research. In September 2005 she received the Docent degree in Organic Chemistry from Göteborg University. After a year in the Arrhenius Laboratory at Stockholm University, focussing on her research, Martina joined us at Bangor in September 2007.
The major focus on her current research comprises the development of new tools and structures for the identification and analysis of carbohydrate recognition domains, directing to a deeper understanding of carbohydrate-protein interactions on the molecular level, which eventually allows a more rational design and development of carbohydrate-based pharmaceuticals. Adhesion of bacteria to human glycoconjugate receptors is a crucial step in the development of many diseases and is often mediated by carbohydrate-protein interactions. As model system, she focuses on the binding of Helicobacter pylori (collaborators S. Oscarson, University College Dublin, and T. Borén, University of Umeå) which induces chronic inflammation by attaching itself to carbohydrate structures in the stomach lining. Another bacterial target is the uropathogenic Escherichia coli (UPEC), accounting for more than 80 % of urinary tract infections. To inhibit the adhesion of bacteria to the bladder is proposed to be an alternative approach to challenge antibiotic resistance. Transferred to the lab-bench this spans from “plain” oligosaccharide synthesis (e.g. Lewis-blood group structures), variously tagged carbohydrate structures (e.g. photolabeling, selenoglycosides) to designed conjugates (e.g. glycocluster, dendrimers).
The exploration of glycosylation reactions, e.g. solvent dependency, and the development of protecting group- and conjugation techniques represents another research-area.
Diddordebau Ymchwil
Research
Welcome to the Carbohydrate Lab!
In our laboratory almost everything orbits carbohydrates. Carbohydrates represent - also outside the lab - the most abundant family of nature products.
Everybody has probably heard about
- their role as energy storage, e.g. as sucrose A - in everyday language just called ‘sugar’,
- their capability supporting tissue in plants, e.g., cellulose B helps building up even the largest trees,
- their ability in keeping many arthropods (as insects, spiders and crustaceans) protected in their sometimes pretty hard ‘skin’, e.g., the lobster’s shell consist mainly of a polysaccharide called chitin C.
However, complex oligosaccharide structures are essential to get biological systems working and carbohydrate structures placed e.g. on the outside of a cell-wall can behave both as flypaper and as signpost for other bio molecules. Two examples:
- the “ABO-blood-groups” are assigned by carbohydrate structures present on the surface of (red blood) cells
- too old red blood cells are sorted out by the liver if they present too little sialic acids (certain carbohydrates) on their surface (because the red blood cells loose them when getting older)
As more as we understand the relevance of carbohydrates and their conjugates, the interest in possible pharmaceutical applications is growing (e.g. development of vaccines). However, compared to peptides the construction of oligosaccharides is not as automated and still often governed by ‘trial and error’.
At this point our research begins:
Our general aim is it to understand the chemistry of carbohydrates as much as possible by studying glycosylation reactions and the development of protecting group-techniques. By doing this, we produce many biologically interesting compounds which are further examined by biochemists and biologists. Since ‘naked’ oligosaccharides are usually too small to produce a response in a biological system, we have to ‘inflate’ them by connecting them to carrier, e.g. proteins. In other cases it is useful to bunch several copies of the carbohydrate structures together by preparing glycoclusters or glycodendrimers. Thus, conjugation of carbohydrate structures via various spacer molecules to a carrier is another area of our research.
Some introductionary reading:
Architectures of Multivalent Glycomimetics for Probing Carbohydrate-Lectin Interactions.
Martina Lahmann
Top. Curr. Chem. 288 (2009), 17-65.
In: "Glycoscience and Microbial Adhesion", Th. K. Lindhorst, St. Oscarson (Eds.), Springer, Berlin/Heidelberg 2009.
Cyfleoedd Project Ôl-radd
Cyhoeddiadau
2021
- CyhoeddwydSakurai Anomeric Allylation of Methyl α-Pyranosides
Bouillon, M., Williams, R. M., Lahmann, M. & McCabe, O., Ion 2021, Carbohydrate chemistry: Proven synthetic methods. Kosma, P., Wrodnigg, T. M. & Stutz, A. (gol.). Boca Raton: CRC Press, Cyfrol 5. t. 55-63
Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion Cynhadledd › Pennod › adolygiad gan gymheiriaid - CyhoeddwydSynthesis of Allyl and Dec-9-Enyl α-d-Mannopyranosides from d-Mannose
Vacchini, M., Cipolla, L., Guizzardi, R., La Ferla, B. & Lahmann, M., Ion 2021, Carbohydrate Chemistry: Proven synthetic methods. Kosma, P., Wrodnigg, T. M. & Stutz, A. (gol.). Boca Raton: CRC Press, Cyfrol 5. t. 189-197
Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion Cynhadledd › Pennod › adolygiad gan gymheiriaid
2020
- CyhoeddwydAn investigation of the antileishmanial properties of semi-synthetic saponins
Anderson, O., Beckett, J., Briggs, C. C., Natrass, L. A., Cranston, C. F., Wilkinson, E. J., Owen, J., Williams, R. M., Loukaidis, A., Bouillon, M., Pritchard, D., Lahmann, M., Baird, M. & Denny, P. W., 1 Gorff 2020, Yn: Medicinal Chemistry. 11, 7, t. 833-842
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydSynthesis of Anemoclemosides A and B, two Saponins Isolated from Anemoclema glaucifolium
Bouillon, M., Bertocco, K., Bischoff, L., Buri, M., Davies, L. R., Wilkinson, E. J. & Lahmann, M., 31 Rhag 2020, Yn: European Journal of Organic Chemistry. 2020, 48, t. 7470-7473
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydSynthesis of Type 1 Lewis b hexasaccharide antigen structures featuring flexible incorporation of L-[U-13C6]-fucose for NMR binding studies
Long, M., Ni Cheallaigh, A., Reihill, M., Oscarson, S. & Lahmann, M., 21 Meh 2020, Yn: Organic and Biomolecular Chemistry. 18, 23, t. 4452-4458
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2019
- CyhoeddwydArchitecture and Evolution of Blade Assembly in β-propeller Lectins
Bonnardel, F., Kumar, A., Wimmerova, M., Lahmann, M., Perez, S., Varrot, A., Lisacek, F. & Imberty, A., 7 Mai 2019, Yn: Structure. 27, 5, t. 764-775
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2018
- CyhoeddwydNEW BIS ESTERS OF IVY SAPOGENINS FOR RUMINANTS
Al-Dulayymi, J., Bouillon, M., Braganca, R., Preskett, D. & Lahmann, M., 10 Hyd 2018, Rhif y patent WO/2016/193309
Allbwn ymchwil: Patent
2017
- CyhoeddwydAntiprotozoal effect of saponins in the rumen can be enhanced by chemical modifications in their structure
Ramos-Morales, E., De La Fuente, G., Duval, S., Wehrli, C., Bouillon, M., Lahmann, M., Preskett, D., Braganca, R. & Newbold, J., 16 Maw 2017, Yn: Frontiers in Microbiology. 8, 399.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydImproving the antiprotozoal effect of saponins in the rumen by combination with glycosidase inhibiting iminosugars or by modification of their chemical structure
Ramos-Morales, E., de la Fuente, G., Nash, R. J., Braganca, R., Duval, S., Bouillon, M., Lahmann, M. & Newbold, J., 8 Medi 2017, Yn: PLoS ONE. 12, 9, e0184517.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydPreparation and immunogenicity of gold glyco-nanoparticles as antipneumococcal vaccine model
Vetro, M., Safari, D., Fallarini, S., Salsabila, K., Lahmann, M., Penades, S., Lay, L., Marradi, M. & Compostella, F., Ion 2017, Yn: Nanomedicine. 12, 1
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2016
- CyhoeddwydIsolation and characterisation of 13 pterosins and pterosides from bracken (Pteridium aquilinum (L.) Kuhn) rhizome
Mohammad, R., Nur-e-Alam, M., Lahmann, M., Parveen, I., Tizzard, G. J., Coles, S. J., Fowler, M., Drake, A. F., Heyes, D. & Thoss, V., Awst 2016, Yn: Phytochemistry. 128, t. 82-94
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydStructural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori
Moonens, K., Gideonsson, P., Subedi, S., Bugaytsova, J., Romaõ, E., Mendez, M., Nordén, J., Fallah, M., Rakhimova, L., Shevtsova, A., Lahmann, M., Castaldo, G., Brännström, K., Coppens, F., Lo, A. W., Ny, T., Solnick, J. V., Vandenbussche, G., Oscarson, S., Hammarström, L., Arnqvist, A., Berg, D. E., Muyldermans, S., Borén, T. & Remaut, H., 13 Ion 2016, Yn: Cell Host and Microbe. 19, 1, t. 55-66
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2015
- CyhoeddwydA roadmap for Glycoscience in Europe: White Paper
Lahmann, M., 2015, Manchester University Press. 16 t.
Allbwn ymchwil: Llyfr/Adroddiad › Adroddiad Comisiwn - CyhoeddwydStereoselective Reduction Using Sodium Triacetoxyborodeuteride: Synthesis of Methyl 2,3-Di-O-benzyl-α-d-(4-2H)-glucopyranoside
Mobarak, H., Engstrom, O., Lahmann, M., Widmalm, G., Roy, R. (gol.) & Vidal, S. (gol.), 27 Mai 2015, Carbohydrate Chemistry: Proven Synthetic Methods: Volume 3. 2015 gol. CRC Press, t. 81-88
Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion Cynhadledd › Pennod
2013
- CyhoeddwydA Soluble Fucose-Specific Lectin from Aspergillus fumigatus Conidia - Structure, Specificity and Possible Role in Fungal Pathogenicity
Houser, J., Komarek, J., Kostlanova, N., Cioci, G., Varrot, A., Kerr, S. C., Lahmann, M., Balloy, V., Fahy, J. F., Chignard, M., Imberty, A. & Wimmerova, M., 10 Rhag 2013, Yn: PLoS ONE.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydLactosamine from lactulose via the Heyns rearrangement: a practical protocol
Shan, Y., Oulaidi Lamiable, F. & Lahmann, M., 24 Gorff 2013, Yn: Tetrahedron Letters. 54, 30, t. 3960-3961
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydMultivalent glycoconjugates as anti-pathogenic agents
Bernardi, A., Jimenez-Barbero, J., Casnati, A., De Castro, C., Darbre, T., Fieschi, F., Finne, J., Funken, H., Jaeger, K-E., Lahmann, M., Lindhorst, T. K., Marradi, M., Messner, P., Molinaro, A., Murphy, P. V., Nativi, C., Oscarson, S., Penades, S., Peri, F., Pieters, R. J., Renaudet, O., Reymond, J-L., Richichi, B., Rojo, J., Sansone, F., Schaeffer, C., Turnbull, W. B., Velasco-Torrijos, T., Vidal, S., Vincent, S., Wennekes, T., Zuilhof, H. & Imberty, A., 2013, Yn: Chemical Society Reviews. 42, 11, t. 4709-4727
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2012
- CyhoeddwydGold nanoparticles as carriers for a synthetic Streptococcus pneumoniae type 14 conjugate vaccine
Safari, D., Marradi, M., Chiodo, F., Dekker, H. A., Shan, Y., Adamo, R., Oscarson, S., Rijkers, G. T., Lahmann, M., Kamerling, J. P., Penadés, S. & Snippe, H., 1 Mai 2012, Yn: Nanomedicine. 7, 5, t. 651-662
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydThe Tyrosine Gate as a Potential Entropic Lever in the Receptor-Binding Site of the Bacterial Adhesin FimH
Wellens, A., Lahmann, M., Touaibiall, M., Vaucher, J., Oscarson, S., Roy, R., Ramaut, H. & Bouckaert, J., 2012, Yn: Biochemistry. 51, 24, t. 4790-4799
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2011
- CyhoeddwydTransformations of chromanol and tocopherol and synthesis of ascorbate conjugates
Lahmann, M. & Thiem, J., 4 Maw 2011, Yn: Tetrahedron. 67, 9, t. 1654-1664
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2010
- CyhoeddwydA TNF-like trimeric lectin domain from Burkholdeda cenocepacia with specificity for fucosylated human histo-blood group antigens.
Šulák, O., Delia, M., Lahmann, M., Varrot, A., Imberty, A. & Wimmerová, M., 13 Ion 2010, Yn: Structure. 18, 1, t. 59-72
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydGlycocluster design for improved avidity and selectivity in blocking human lectin/plant toxin binding to glycoproteins and cells.
Andre, S., Lahmann, M., Gabius, H. J. & Oscarson, S., 6 Rhag 2010, Yn: Molecular Pharmaceutics. 7, 6, t. 2270-2279
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydSynthesis of 6-PEtN-α-D-GalpNAc-(1–>6)-β-D-Galp-(1–>4)-β-D-GlcpNAc-(1–>3)-β-D-Galp-(1–>4)-β-D-Glcp, a Haemophilus influenzae lipopolysacharide structure, and biotin and protein conjugates thereof.
Sundgren, A., Lahmann, M. & Oscarson, S., 26 Gorff 2010, Yn: Beilstein Journal of Organic Chemistry. 6, t. 704-708
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydSynthesis of the Lewis b pentasaccharide and a HAS-conjugate thereof.
Fourniere, V., Skantz, L., Sajtos, F., Oscarson, S. & Lahmann, M., 22 Gorff 2010, Yn: Tetrahedron.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2009
- CyhoeddwydArchitectures of Multivalent Glycomimetics for Probing Carbohydrate–Lectin Interactions.
Lahmann, M., 1 Ion 2009, Yn: Topics in Current Chemistry. 288, t. 17-65
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydReversible non-covalent derivatisation of carbon nanotubes with glycosides.
Andersson, C. H., Lahmann, M., Oscarson, S. & Grennberg, H., 1 Ion 2009, Yn: Soft Matter. 5, 14, t. 2713-2716
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2008
- CyhoeddwydAtomic mapping of the sugar interactions in one-site and two-site mutants of Cyanovirin-N by NMR spectroscopy
Sandstrom, C., Hakkarainen, B., Matei, E., Glinchert, A., Lahmann, M., Oscarson, S., Kenne, L. & Gronenborn, A. M., 25 Maw 2008, Yn: Biochemistry. 47, 12, t. 3625-3635
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydIdentification of the smallest structure capable of evoking opsonophagocytic antibodies against Streptococcus pneumoniae type 14
Safari, D., Dekker, H. A. T., Joosten, J. A. F., Michalik, D., de Souza, A. C., Adamo, R., Lahmann, M., Sundgren, A., Oscarson, S., Kamerling, J. P. & Snippe, H., Hyd 2008, Yn: Infection and Immunity. 76, 10, t. 4615-4623
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydInvestigations of glycosylation reactions with 2-N-acetyl-2N,3O-oxazolidinone-protected glucosamine donors.
Olsson, J. D., Eriksson, L., Lahmann, M. & Oscarson, S., 19 Medi 2008, Yn: Journal of Organic Chemistry. 73, 18, t. 7181-7188
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2007
- CyhoeddwydNMR study of hydroxy protons of di- and trimannosides, substructures of Man-9
Hakkarainen, B., Kenne, L., Lahmann, M., Oscarson, S. & Sandstrom, C., 1 Rhag 2007, Yn: Magnetic Resonance in Chemistry. 45, 12, t. 1076-1080
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydSynthesis of urine drug metabolites: glucuronic acid glycosides of phenol intermediates
Arewang, C. J., Lahmann, M., Oscarson, S. & Tiden, A. K., 21 Mai 2007, Yn: Carbohydrate Research. 342, 7, t. 970-974
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2006
- CyhoeddwydSynthesis of monodeoxy analogues of the trisaccharide alpha-D-Glcp-(1 -> 3)-alpha-D-Manp-(1 -> 2)-alpha-D-ManpOMe recognised by calreticulin/calnexin
Gemma, E., Lahmann, M. & Oscarson, S., 24 Gorff 2006, Yn: Carbohydrate Research. 341, 10, t. 1533-1542
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydSynthesis of oligosaccharides corresponding to Vibrio cholerae O139 polysaccharide structures containing dideoxy sugars and a cyclic phosphate
Turek, D., Sundgren, A., Lahmann, M. & Oscarson, S., 1 Ion 2006, Yn: Organic and Biomolecular Chemistry. 4, 7, t. 1236-1241
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - Cyhoeddwydbeta-propeller crystal structure of Psathyrella velutina lectin: An integrin-like fungal protein interacting
Cioci, G., Mitchell, E. P., Chazalet, V., Debray, H., Oscarson, S., Lahmann, M., Gautier, C., Breton, C., Perez, S. & Imberty, A., 14 Ebrill 2006, Yn: Journal of Molecular Biology. 357, 5, t. 1575-1591
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2005
- CyhoeddwydBlock synthesis of Streptococcus pneumoniae type 14 capsular polysaccharide structures
Sundgren, A., Lahmann, M. & Oscarson, S., 1 Mai 2005, Yn: Journal of Carbohydrate Chemistry. 24, 4-6, t. 379-391
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydEthyl 2-acetamido-4,6-di-O-benzyl-2,3-N,O-carbonyl-2-deoxy-1-thio-beta-glycopyranoside as a versatile GlcNAc donor
Boysen, M., Gemma, E., Lahmann, M. & Oscarson, S., 1 Ion 2005, Yn: Chemical Communications. 24, t. 3044-3046
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydImpact of natural variation in bacterial F17G adhesins on crystallization behaviour
Buts, L., Wellens, A., Van Molle, I., Wyns, L., Loris, R., Lahmann, M., Oscarson, S., de Greve, H. & Bouckaert, J., 1 Awst 2005, Yn: Acta Crystallographica Section D: Biological Crystallography. 61, 8, t. 1149-1159
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydSynthesis of the tetrasaccharide alpha-D-Glcp(1 -> 3)-alpha-D-Manp-(1 -> 2)-alpha-D-Manp-(1 -> 2)-alpha-D-Manp recognized by calreticulin/calnexin
Gemma, E., Lahmann, M. & Oscarson, S., 21 Tach 2005, Yn: Carbohydrate Research. 340, 16, t. 2558-2562
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydThe fucose-binding lectin from Ralstonia solanacearum - A new type of beta-propeller architecture formed by oligomerization and interacting with fucoside, fucosyllactose, and plant xyloglucan
Kostlanova, N., Mitchell, E. P., Lortat-Jacob, H., Oscarson, S., Lahmann, M., Gilboa-Garber, N., Chambat, G., Wimmerova, M. & Imberty, A., 29 Gorff 2005, Yn: Journal of Biological Chemistry. 280, 30, t. 27839-27849
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2004
- CyhoeddwydFunctional adaptation of BabA, the H-pylori ABO blood group antigen binding adhesion
Aspholm-Hurtig, M., Dailide, G., Lahmann, M., Kalia, A., Ilver, D., Roche, N., Vikstrom, S., Sjostrom, R., Linden, S., Backstrom, A., Lundberg, C., Arnqvist, A., Mahdavi, J., Nilsson, U. J., Velapatino, B., Gilman, R. H., Gerhard, M., Alarcon, T., Lopez-Brea, M., Nakazawa, T., Fox, J. G., Correa, P., Dominguez-Bello, M. G., Perez-Perez, G. I., Blaser, M. J., Normark, S., Carlstedt, I., Oscarson, S., Teneberg, S., Berg, D. E. & Boren, T., 1 Gorff 2004, Yn: Science. 305, 5683, t. 519-522
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydLigands of the asialoglycoprotein receptor for targeted gene delivery, part 1: Synthesis of and binding studies with biotinylated cluster glycosides containing N-acetylgalactosamine
Westerlind, U., Westman, J., Tornquist, E., Smith, C. I., Oscarson, S., Lahmann, M. & Norberg, T., 1 Ion 2004, Yn: Glycoconjugate Journal. 21, 5, t. 227-241
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydSynthesis of the Lewis b hexasaccharide and HSA-conjugates thereof.
Lahmann, M., Bulow, L., Teodorovic, P., Gyback, H. & Oscarson, S., 1 Medi 2004, Yn: Glycoconjugate Journal. 21, 5, t. 251-256
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydSynthesis of urine drug metabolites: glucuranosyl esters of carboxymefloquine, indoprofen, (S)-naproxen and desmethyl (S)-naproxen
Lahmann, M., Bergstrom, M. A., Turek, D. & Oscarson, S., 1 Rhag 2004, Yn: Journal of Carbohydrate Chemistry. 23, 2, t. 123-132
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2003
- CyhoeddwydDesign and synthesis of HIV-1 protease inhibitors. Novel tetrahydrofuran P2/P2 '-groups interacting with Asp29/30 of the HIV-1 protease. Determination of binding from X-ray crystal structure of inhibitor protease complex
Oscarsson, K., Lahmann, M., Lindberg, J., Kangasmetsa, J., Unge, T., Oscarson, S., Hallberg, A. & Samuelsson, B., 20 Maw 2003, Yn: Bioorganic and Medicinal Chemistry. 11, 6, t. 1107-1115
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydSmI2/water/amine mediates cleavage of allyl ether protected alcohols: Application in carbohydrate synthesis and mechanistic considerations
Dahlen, A., Sundgren, A., Lahmann, M., Oscarson, S. & Hilmersson, G., 30 Hyd 2003, Yn: Organic Letters. 5, 22, t. 4085-4088
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydSolving the phase problem for carbohydrate-binding proteins using selenium derivatives of their ligands: a case study involving the bacterial F17-G adhesin
Buts, L., Loris, R., De Genst, E., Oscarson, S., Lahmann, M., Messens, J., Brosens, E., Wyns, L., De Greve, H. & Bouckaert, J., 1 Meh 2003, Yn: Acta Crystallographica Section D: Biological Crystallography. 59, 6, t. 1012-1015
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydSynthesis of dihydrodiosgenin glycosides as mimetics of bidesmosidic steroidal saponins
Suhr, R., Lahmann, M., Oscarson, S. & Thiem, J., 17 Hyd 2003, Yn: European Journal of Organic Chemistry. 20, t. 4003-4011
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydThe fimbrial adhesin F17-G of enterotoxigenic Escherichia coli has an immunoglobulin-like lectin domain that binds N-acetylglucosamine
Buts, L., Bouckaert, J., De Genst, E., Loris, R., Oscarson, S., Lahmann, M., Messens, J., Brosens, E., Wyns, L. & De Greve, H., 1 Awst 2003, Yn: Molecular Microbiology. 49, 3, t. 705-715
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2002
- CyhoeddwydA facile approach to diosgenin and furostan type saponins bearing a 3 beta-chacotriose moiety
Lahmann, M., Gyback, H., Garegg, P. J., Oscarson, S., Suhr, R. & Thiem, J., 19 Tach 2002, Yn: Carbohydrate Research. 337, 21-23, t. 2153-2159
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydInvestigation of the reactivity difference between thioglycoside donors with variant aglycon parts
Lahmann, M. & Oscarson, S., 1 Awst 2002, Yn: Canadian Journal of Chemistry. 80, 8, t. 889-893
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydSynthesis of a polyphosphorylated GPI-anchor core structure.
Lahmann, M., Garegg, P. J., Konradsson, P. & Oscarson, S., 1 Awst 2002, Yn: Canadian Journal of Chemistry. 80, 8, t. 1105-1111
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2000
- CyhoeddwydOne-pot oligosaccharide synthesis exploiting solvent reactivity effects
Lahmann, M. & Oscarson, S., 30 Tach 2000, Yn: Organic Letters. 2, 24, t. 3881-3882
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
1997
- CyhoeddwydSynthesis of alpha-tocopheryl oligosaccharides
Lahmann, M. & Thiem, J., 26 Maw 1997, Yn: Carbohydrate Research. 299, 1-2, t. 23-31
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Gweithgareddau
2015
- Member of COST Management Committee, European Cooperation in Science and Technology (COST Network)
2015 →
Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Aelod)
Projectau
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Towards the Synthesis of a Fucosylated Chondroitin Sulfate Library, part 2
01/06/2016 – 23/02/2017 (Wedi gorffen)
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Towards the Synthesis of a Fucosylated Chondroitin Sulfate Library
01/06/2015 – 24/02/2017 (Wedi gorffen)
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Saponins evaluation for efficacy against liver fluke
01/04/2015 – 01/08/2019 (Wedi gorffen)
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Highly bioactive saponins from a cell culture approach
03/02/2014 – 08/09/2016 (Wedi gorffen)
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01/10/2012 – 31/08/2016 (Wedi gorffen)
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01/01/2001 – 14/12/2009 (Wedi gorffen)