UWB Crest

Research in the School of Psychology

David Linden - Further Detail

Lab members:

Biological Psychiatry Group:

Tom Lancaster, Ph.D. student, School of Medical Sciences

Kathryn Hall

Leena Subramanian, Ph.D . student

Social cognitive neuroscience (joint ESRC/DFG grant with Prof Thomas Mussweiler, Cologne University)

Dr Ullrich Wagner

Emotion and Working Memory (BBSRC grant with Prof Jane Raymond, Dr John Hindle, Dr Margaret Jackson)

Current projects:

  • Cognitive integration in visual working memory investigated with functional magnetic resonance imaging, electroencephalography (collaboration with Dr. Christoph Klein) and transcranial magnetic stimulation (collaboration with Prof. Bob Rafal)
  • Visual working memory & emotions (collaboration with Prof. Jane Raymond)
  • Influence of genetic polymorphisms on behaviour and brain activity (collaboration with Prof. Johannes Thome, Swansea Clinical School)
  • Effects of electroconvulsive therapy on brain activity and memory (collaboration with Prof. David Healy, North Wales Dept. of Psychological Medicine)
  • Biological and psychological determinants and correlates of auditory hallucinations
  • Brain effects of cognitive rehabilitation in dementia (collaboration with Prof. Linda Clare and Prof. Bob Woods, funded by the Alzheimer’s Society)
  • Neural substrates of social comparison (collaboration with Thomas Mussweiler, Cologne University, funded by ESRC and German Research Council)
  • Neurofeedback with functional magnetic resonance imaging (collaboration with Dr. Stephen Johnston and Dr. Stephan Boehm)
  • Neural mechanisms of alcohol craving and motivational goals (collaboration with Prof. Miles Cox and Dr. Niklas Ihssen)

Selected recent publications:

C. Wolf, M.C. Jackson, C. Kissling, J. Thome, D.E.J. Linden.Dysbindin-1 genotype effects on emotional working memory. MolPsychiatry, 2010 [Epub ahead of print].

L. Clare, D.E. J. Linden, R.T. Woods, R. Whitaker, S.J. Evans, C.H. Parkinson, J. van Paasschen, S.M. Nelis, Z. Hoare, K. Yuen, M.D. Rugg. Goal-oriented Cognitive Rehabilitation for People with Early-stage Alzheimer’s Disease: a Single-blind Randomized Controlled Trial of Clinical Efficacy. Am J Geriatric Psychiatry, in press.

I. SanMiguel, D.E.J. Linden, C. Escera. Attention capture by novel sounds: Distraction vs. Facilitation. European Journal of Cognitive Psychology, in press.

V. Oertel, C. Knoechel, A. Rotarska-Jagiela, R. Schoenmeyer, M. Lindner, V. van de Ven, C. Haenschel, P. Uhlhaas, K. Maurer, D.E.J. Linden (2010). Reduced laterality as a trait marker of schizophrenia - evidence from structural and functional neuroimaging. J Neurosci 30 2289-2299.

L.I. Kuncheva, J.J. Rodriguez, C.O. Plumpton, D.E.J. Linden, S.J. Johnston (2010). Random subspace ensembles for FMRI classification. IEEE Trans Med Imaging 29:531-42.

A. Rotarska-Jagiela, V. van de Ven, V. Oertel-Knoechel, P.J. Uhlhaas, K. Vogeley, D.E.J. Linden. Resting-state functional network correlates of psychotic symptoms in schizophrenia. Schizophr Res, 2010 Jan 22.

H.M. Morgan, M.C. Jackson, C. Klein, H. Mohr, K.L.Shapiro, D.E.J. Linden (2010). Neural signatures of stimulus features in visual working memory ? a spatiotemporal approach. Cerebral Cortex 20:187-97.

J.S. Mayer, A. Roebroeck, K. Maurer, D.E.J. Linden (2010). Specialization in the default mode: Task-induced brain deactivations dissociate between visual working memory and attention. Hum Brain Mapp. 31:126-39.

S.J. Johnston, S.G. Boehm, D. Healy, R. Goebel, D.E. Linden (2010). Neurofeedback: A promising tool for the self-regulation of emotion networks. Neuroimage 49:1066-72.

S.C. Linden, M.C. Jackson, L. Subramanian, C. Wolf, P. Green, D. Healy, D.E.J. Linden. Emotion-cognition interactions in schizophrenia: Implicit and explicit effects of facial expression. Neuropsychologia, 27 Nov 2009.

I. SanMiguel, H. Morgan, C. Klein, D.E.J. Linden, C. Escera. On the functional significance of Novelty-P3: Facilitation by unexpected novel sounds. Biological Psychology, 4 Dec 2009.

D.E.J. Linden, A. Fallgatter (2009) Neuroimaging in psychiatry: from bench to bedside. Front. Hum. Neurosci. 3:49. doi: 10.3389/neuro.09.049.2009

C. Haenschel, R.A. Bittner, J. Waltz, F. Haertling, M. Wibral, W. Singer, D.E.J. Linden, E. Rodriguez (2009). Cortical oscillatory activity is critical for working memory as revealed by deficits in early-onset schizophrenia. J Neurosci 29:9481-9.

V. Oertel, A. Rotarska-Jagiela, V. van de Ven, C. Haenschel , M. Grube, U. Stangier, K. Maurer, D.E.J. Linden (2009). Mental imagery vividness as a trait marker across the schizophrenia spectrum. Psychiatry Res. 167:1-11.

L. Clare, J. van Paasschen, S. Evans, C. Parkinson, R.T. Woods, D.E.J. Linden. Goal-oriented cognitive rehabilitation for an individual with Mild Cognitive Impairment: behavioural and neuroimaging outcomes. Neurocase. 2009 Mar 16:1-14.

M.C. Jackson, C.-Y. Wu, D.E.J. Linden, J.E. Raymond (2009). Enhanced visual short-term memory for angry faces. Journal of Experimental Psychology - Human Perception and Performance 35: 363-74.

M.C. Jackson, C. Wolf, S.J. Johnston, J.E. Raymond, D.E.J. Linden (2008). Neural correlates of enhanced visual short-term memory for angry faces: An fMRI study. PLoS ONE 3, e3536. (Download the paper)

D.E.J. Linden (2008). Brain imaging and psychotherapy - methodological considerations and practical implications. Eur Arch Psychiatry Clin Neurosci 258 Supp l 5:71-5.

R. Cohen Kadosh, K. Cohen Kadosh, A. Henik, and D.E.J. Linden (2008). Processing Conflicting Information: Facilitation, Interference, and Functional Connectivity. Neuropsychologia 46, 2872-9.

P.J. Uhlhaas, J. Pantel, H. Lanfermann, D. Prvulovic, C. Haenschel, K. Maurer, D.E.J. Linden (2008). Visual Perceptual Organization Deficits in Alzheimer?s Dementia. Dement Geriatr Cogn Disord 25, 465-475.

M. Lindner, T. Hundhammer, A. Ciaramidaro, D.E.J. Linden, T. Mussweiler (2008). The neural substrates of person comparison - An fMRI study. Neuroimage 40, 963-71.

H.M. Morgan, C. Klein, S.G. Boehm, K.L. Shapiro, D.E.J. Linden (2008). Working memory load for faces modulates P300, N170, and N250r. J  Cogn Neurosci 20, 989-1002. (Download the paper)

A. Rotarska-Jagiela, R. Schönmeyer, V. Oertel , C. Haenschel, K. Vogeley, D.E.J. Linden (2008).The corpus callosum in schizophrenia - volume and connectivity changes affect specific regions. Neuroimage 39, 1522-32.

C. Haenschel, R.A. Bittner, F. Haertling, A. Rotarska-Jagiela, K. Maurer, W. Singer, D.E.J. Linden (2007) Impaired early-stage visual processing contributes to working memory dysfunction in adolescents with schizophrenia ? a study with event-related potentials. Arch Gen Psychiatry 64, 1229-1240.

V. Oertel, A. Rotarska-Jagiela, V. van de Ven, C. Haenschel, K. Maurer, D.E.J. Linden (2007). Visual Hallucinations in Schizophrenia investigated with functional magnetic resonance imaging. Psychiatry Research Neuroimaging 156, 269-73.

External collaborations:

Upcoming meetings & talks:

Italian Society for Neurological Rehabilitation, 10th Annual Meeting, Palermo 22-24 April 2010: http://www.aristea.com/sirn2010/

Press coverage of our work

Sueddeutsche Zeitung, Germany, 6 October 2008:
http://www.perlentaucher.de/feuilletons/2008-10-06.html

Neue Zuercher Zeitung, Switzerland, 15 October 2008: http://www.nzz.ch/nachrichten/wissenschaft/das_tor_zur_realitaet_im_gehirn_1.1108331.html