Reader in organic chemistry, interests in natural product isolation and synthesis, reagent chemistry, asymmetric chemistry, asymmetric catalysis, new reactions, biosynthesis and abiogenesis.

Dr Patrick J. Murphy

School of Natrual Sciences 

Alun Roberts Building

Bangor

LL57 2UW

Tel: 01248 382375

Email:  chs027@bangor.ac.uk

Research

We have a longstanding interest in guanidine containing natural products and the development of synthetic methodology for their preparation, this research has targeted the total synthesis of several sponge metabolites, for example crabescindine 359, the batzelladines and the cylindrospermopsin alkaloids isolated from several species of cyanobacteria. We are also interested in other guanidine containing biomolecules for example the unusual amino acid enduracididine isolated from the seeds of Lonchocurpus sericeus and nitensidines D and E isolated from the leaves of Pterogyne nitens which exhibited cytotoxicity towards HL-60 (human myeloblastic leukemia) and SF-245 (human glioblastoma) cells. Other targets include the novel β-carboline guanidine derivative tiruchanduramine a potent α-glucosidase inhibitor isolated from the Indian ascidian Synoicum macroglossum and trachycladindoles G a cytotoxic guanidine isolated from the marine sponge Trachycladus laevispirulifer.

As part of our general methodology, we have developed a variety of conjugate addition strategies as well as utilizing ring opening reactions of epoxides with guanidines and iodocyclisation of protected guanidines for the synthesis of novel guanidine heterocycles. 

Other project areas include:

o Parasitology; development of new lead compounds.

o Antisense Oligonucleotide agents for treatment of Chronic Myeloid Leukaemia

o Abiogenesis; peptide evolution and the effects of H-bonding

o Asymmetric catalysis; organocatalysis and transition metal mediated synthesis

o Natural product isolation

o Chiral lithium amide mediated asymmetric synthesis

o Asymmetric phase transfer catalysis

o Intramolecular Baylis-Hillman and Rauhut-Currier reactions

o Materials chemistry

o Novel quinone based pro-drug delivery systems

2024

• PublishedC2-Symmetric Amino Acid Amide-Derived Organocatalysts
  Al-Taie, Z., Coles, S. J., Horton, P., Kraehenbuehl, R., Murphy, P. & Tizzard, G., 24 Aug 2024, In: Reactions. 5, 3, p. 567-586
  Research output: Contribution to journal › Article › peer-review

2022

• PublishedCyclic guanidine containing amino acids that promote glucocerebrosidase
  Al-Taie, Z. S., Bartholomew, B., Coles, S. J., Evans, D. M., Hollinshead, J., Jones, L. F., Kraehenbuehl, R., Murphy, P. J., Nash, R. J., Penkova, Y. B. & Tizzard, G. J., 24 Sept 2022, In: Tetrahedron. 123, 132959.
  Research output: Contribution to journal › Article › peer-review
• PublishedPropiedades electroquímicas y espectroscópicas de los ditieniletilenos y sus polímeros
  Anjos, T., Altaie, Z., Roberts-Bleming, S. J., Kalaji, M. & Murphy, P., 2022, In: Revista de Ingenieria y Tecnologia Educativa. 5, 1, p. 41-55
  Research output: Contribution to journal › Article › peer-review
• PublishedSynthesis of (+)-(R)-Tiruchanduramine
  Al-Taie, Z. S., Bartholomew, B., Cartmell, C., Froom, R., Kerr, R. G., Kraehenbuehl, R., Murphy, P., Nash, R. J., Penkova, Y. B. & van Teijlingen, A., 16 Feb 2022, In: Molecules. 27, 4
  Research output: Contribution to journal › Article › peer-review

2021

• Published1,1′,2,2′-Tetralithioferrocene and 1,1′,2,2′,3,3′-Hexalithioferrocene: Useful Additions to Ferrocene Precursor Compounds
  Butler, I., Evans, D., Horton, P., Coles, S. & Murphy, P., 8 Mar 2021, In: Organometallics. 40, 5, p. 600-605 6 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedN-carbamate protected amino acid derived guanidine organocatalysts
  Al-Taie, Z. S., Anderson, J. M., Bischoff, L., Christensen, J., Coles, S. J., Froom, R., Gibbard, M. E., Jones, L. F., de Kleijne, F. F. J., Murphy, P. & Thompson, E., 4 Jun 2021, In: Tetrahedron. 89, 132093.
  Research output: Contribution to journal › Article › peer-review
• PublishedSynthetic Route to 1,1′,2,2′-Tetraiodoferrocene That Avoids Isomerization and the Electrochemistry of Some Tetrahaloferrocenes
  Evans, D. M., Hughes, D. D., Murphy, P. J., Horton, P. N., Coles, S. J., de Biani, F. F., Corsini, M. & Butler, I. R., 9 Aug 2021, In: Organometalics. 40, 15, p. 2496-2503 8 p.
  Research output: Contribution to journal › Article › peer-review

2020

• PublishedPolymethoxy-1-Alkenes Screening of Chlorella and Spirulina Food Supplements Coupled with In Vivo Toxicity Studies
  Henao, E., Murphy, P., Falfushynska, H., Horyn, O., Evans, D. & Rzymski, P., Feb 2020, In: Toxins. 12, 2, 111.
  Research output: Contribution to journal › Article › peer-review
• PublishedQuorum sensing N-Acyl homoserine lactones are a new class of anti-schistosomal
  Whiteland, H., Crusco, A., Bloemberg, L. W., Tibble-Howlings, J., Forde-Thomas, J., Coghlan, A., Murphy, P. J. & Hoffmann, K. F., 19 Oct 2020, In: PLoS Neglected Tropical Diseases. 14, 10, p. e0008630
  Research output: Contribution to journal › Article › peer-review
• PublishedSynthesis of Zephycandidine A from Haemanthamine
  Murphy, P., Tibble-Howlings, J., Kowalczyk, R. M. & Stevens, K., 16 Apr 2020, In: Tetrahedron Letters. 61, 16, 151785.
  Research output: Contribution to journal › Article › peer-review

2019

• PublishedA study of polymethoxy-1-alkenes in Raphidiopsis (Cylindrospermopsis) raciborskii and Aphanizomenon gracile isolated in Poland
  Rzymskic, P., Evans, D., Murphy, P. & Kokocinski, M., 5 Dec 2019, In: Toxicon. 171, p. 51-53
  Research output: Contribution to journal › Article › peer-review
• PublishedElucidating cylindrospermopsin toxicity via synthetic analogues: An in vitro approach
  Murphy, P., Evans, D., Hughes , J., Jones, L., Falfushynska, H., Horyn, O., Sokolova, I., Christensen, J., Coles, S. & Rzymskic, P., Nov 2019, In: Chemosphere. 234, p. 139-147 9 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedSlight changes in the chemical structure of haemanthamine greatly influence the effect of the derivatives on rumen fermentation in vitro
  Ramos-Morales, E., Braganca, R., Murphy, P., Tibble-Howlings, J. & Newbold, C. J., 21 Feb 2019, In: Scientific Reports. 8 p.
  Research output: Contribution to journal › Article › peer-review

2017

• PublishedA synthesis of tiruchanduramine and a reinvestigation of its glycosidase inhibitory activity
  Buck, M., Evans, D., Evans, V. A., Herkt, D., Sharp, H., Hollinshead, J., Mitschang, F., Murphy, P., Nash, R. J. & Wenbourne, J., 3 Aug 2017, In: Tetrahedron. 73, 31, p. 4545-4548
  Research output: Contribution to journal › Article › peer-review
• PublishedIntramolecular epoxide ring opening cyclisation reactions involving guanidines
  Al-Shuhaib, Z., Arndt, M., Dennis, M., Evans, D., Jones, I., Leitmann, V., Murphy, P., Roberts, D., Rowles, R., Sadaghiani, Y. K., Thornhill, A. J., Nash, R. J., Hollinshead, J., Bartholomew, B., Tizzard, G. & Coles, S., 16 Feb 2017, In: Tetrahedron. 73, 7, p. 845-852 8 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedSynthetic analogues of cyanobacterial alkaloid cylindrospermopsin and their toxicological activity
  Cartmell, C., Evans, D., Elwood, J. M., Fituri, H., Murphy, P., Caspari, T., Poniedziałekc, B. & Rzymskic, P., Oct 2017, In: Toxicology in Vitro. 44, p. 172-181
  Research output: Contribution to journal › Article › peer-review

2016

• PublishedAnalogues of Marine Guanidine Alkaloids Are in Vitro Effective against Trypanosoma cruzi and Selectively Eliminate Leishmania (L.) infantum Intracellular Amastigotes
  Martins, L. F., Mesquita, J. T., Pinto, E. G., Costa-Silva, T. A., Borborema, S. E. T., Galisteo Junior, A. J., Neves, B. J., Andrade, C. H., Bennett, E., Black, G., Harper, P., Evans, D., Fituri, H., Leyland, J. P., Martin, C., Roberts, T., Thornhill, A. J., Vale, S., Howard-Jones, A. & Thomas, D. & 5 others, Williams, H. L., Overman, L., Berlinck, R., Murphy, P. & Tempone, A., 16 Sept 2016, In: Journal of natural products. 79, 9, p. 2202-2210 9 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedSynthesis, applications and mechanistic investigations of C2 Symmetric Guanidinium salts
  Allingham, M. T., Bennett, E. L., Davies, D., Harper, P. M., Howard-Jones, A. G., Mehdar, Y. T., Murphy, P. J., Thomas, D., Caulkett, P. W., Potter, D., Lam, C. M. & O'Donoghue, A. C., 28 Jan 2016, In: Tetrahedron. 72, 4, p. 496-503
  Research output: Contribution to journal › Article › peer-review

2015

• PublishedAnti-parasitic Guanidine and Pyrimidine Alkaloids from the Marine Sponge Monanchora arbuscula
  Santos, M. F., Harper, P. M., Williams, D. E., Mesquita, J. T., Pinto, E. G., da Costa-Villa, T. A., Hajdu, E., Ferreira, A. G., Santos, R. A., Murphy, P. J., Anderson, R. J., Tempone, A. G. & Berlinck, R. G., 29 Apr 2015, In: Journal of natural products. 78, 5, p. 1101-1112
  Research output: Contribution to journal › Article › peer-review
• PublishedHow the Surface Structure Determines the Properties of CuH
  Bennett, E. L., Bennett, E., Wilson, T., Murphy, P. J., Refson, K., Hannon, A. C., Imberti, S., Callear, S. K., Chass, G. A. & Parker, S. F., 11 Feb 2015, In: Inorganic Chemistry. 54, 5, p. 2213-2220
  Research output: Contribution to journal › Article › peer-review
• PublishedMarine guanidine derivatives affect the redox biology of Leishmania infantum and downregulate cytokines of macrophages
  Tempone, A. G., Martins, L. F., Bennett, E. L., Black, G. P. & Murphy, P. J., 1 Nov 2015, In: Planta Medica. 81, 16, p. 1470-1471
  Research output: Contribution to journal › Article › peer-review
• PublishedStructure and spectroscopy of CuH prepared via borohydride reduction
  Bennett, E. L., Wilson, T., Murphy, P. J., Refson, K., Hannon, A. C., Imberti, S., Callear, S. K., Chass, G. A. & Parker, S. F., 7 Nov 2015, In: Acta Crystallographica Section B. 7, 6, p. 608-612
  Research output: Contribution to journal › Article › peer-review

2014

• PublishedCharacterization of the hydrides in Stryker's reagent: [HCuP(C 6H5)3]6
  Bennett, E. L., Murphy, P. J., Imberti, S. & Parker, S. F., 26 Feb 2014, In: Inorganic Chemistry. 53, 6, p. 2963-2967 5 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedIodocyclisations reactions of Boc- and Cbz-protected N-allylguanidines
  Al-Shuhaib, Z. A., Al Shuhaiba, Z., Davies, D. H., Dennis, M., Evans, D. M., Fletcher, M. D., Franken, H., Hancock, P., Hollinshead, J., Jones, I., Kähm, K., Murphy, P. J., Nash, R. P. & Rowles, R., 15 Apr 2014, In: Tetrahedron. 70, 29, p. 4412-4419
  Research output: Contribution to journal › Article › peer-review
• PublishedPreparation of an ABC tricyclic model of the cylindrospermopsin alkaloids via a biomimetically inspired pathway
  Murphy, P. J., Evans, D. M., Horton, P. N. & Hursthouse, M. B., 28 Apr 2014, In: RSC Advances. 4, 40, p. 20744-20751
  Research output: Contribution to journal › Article › peer-review
• PublishedSynthetic marine guanidines are effective antileishmanial compounds by altering the plasma membrane permeability
  Tempone, A. G., Martins, L. F., Pinto, E. G., Mesquita, J. T., Bennett, E. L., Black, G. P. & Murphy, P. J., 1 Oct 2014, In: Planta Medica. 80, p. 1460
  Research output: Contribution to journal › Article › peer-review

2013

• PublishedDye-sensitized solar cells (DSSCs) based on poly(3-hexylthioacetate thiophene)
  Manji, A. J. & Murphy, P. J., 9 Jan 2013, In: International Journal of Physical Sciences. 8, 1, p. 16-26
  Research output: Contribution to journal › Article › peer-review
• PublishedIntramolecular palladium mediated π-allyl cyclisation of bis-Cbz- and bis-Boc-protected guanidines
  Al-Shuhaib, Z. A., Doerksen, E., Page, J. M., Al-Shuhaiba, Z., Böckemeier, H., Coghlan, L., Dörksena, E., Jones, I. V., Murphy, P. J. & Nash, R. P., 27 Sept 2013, In: Tetrahedron Letters. 54, 49, p. 6716-6718
  Research output: Contribution to journal › Article › peer-review
• PublishedSelf sensitized photooxidation of tetrathienyltetrathiafulvalenes: synthesis of thienyl substituted 1,2,5,8-tetrathiecine-6,7-dione, a new heterocyclic system
  Charlton, A., Donati, D., Fusi, S., Murphy, P. J. & Ponticelli, F., 6 Mar 2013, In: Tetrahedron Letters. 54, 10, p. 1227-1229
  Research output: Contribution to journal › Article › peer-review
• PublishedSynthesis and biological activity of analogues of batzelladine F
  Vale, S. A., Bennett, E. L., Black, G. P., Brown, P., Hizi, A., Jaffar, M., Leyland, J. P., Martin, C., Oz-Gleenberg, I., Murphy, P. J., Roberts, T. D. & Thornhill, A. J., 6 Feb 2013, In: Tetrahedron. 69, 14, p. 3061-3066
  Research output: Contribution to journal › Article › peer-review

2012

• PublishedTriacylglycerol composition of British bluebell (Hyacinthoides non-scripta) seed oil
  Thoss, V., Murphy, P. J., Marriott, R. & Wilson, T., 10 Apr 2012, In: RSC Advances. 12, 2, p. 5314-5322
  Research output: Contribution to journal › Article › peer-review

2011

• PublishedA biomimetic approach to the cylindrospermopsin alkaloids
  Evans, D. M. & Murphy, P. J., 21 Mar 2011, In: Chemical Communications. 47, 11, p. 3225-3226 2 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedThe Cylindrospermopsin Alkaloids
  Evans, D. M. & Murphy, P. J., 2011, In: Alkaloids: Chemistry and Biology. 70, p. 1-77 77 p.
  Research output: Contribution to journal › Article › peer-review

2010

• PublishedIodocyclisation and rearrangement reactions of mono-protected allyl substituted guanidines.
  Davies, D., Fletcher, M. D., Franken, H., Hollinshead, J., Kahm, K., Murphy, P. J., Nash, R. & Potter, D. M., 29 Dec 2010, In: Tetrahedron Letters. 51, 52, p. 6825-6829
  Research output: Contribution to journal › Article › peer-review

2009

• PublishedElectropolymerization Studies on a Series of Thiophene-Substituted 1,3-Dithiole-2-ones: Solid-State Preparation of a Novel TTF-Derivatized Polythiophene.
  Anjos, T., Charlton, A., Coles, S. J., Croft, A. K., Hursthouse, M. B., Kalaji, M., Murphy, P. J. & Roberts-Bleming, S. J., 14 Apr 2009, In: Macromolecules. 42, 7, p. 2505-2515
  Research output: Contribution to journal › Article › peer-review
• PublishedSynthesis and photoreactivity of aryl substituted 4,5-dithienyl[1,3]dithiol-2-ones.
  Blencowe, A., Celli, A. M., Donati, D., Hayes, W. C., Martin, C., Murphy, P. J., Ponticelli, F. & Melville-Richards, J. K., 9 May 2009, In: Tetrahedron. 65, 19, p. 3858-3862
  Research output: Contribution to journal › Article › peer-review
• PublishedSynthesis, structure and spectroscopic properties of a new class of polymerisable nickel dithiolenes
  Dalgleish, S., Morrison, C. A., Middlemiss, D. S., Mount, A. R., Collins, A., Pilia, L., Serpe, A., Mercuri, M. L., Roberts-Bleming, S. J., Charlton, A., Deplano, P., Murphy, P. J. & Robertson, N., 1 Jan 2009, In: Journal of Materials Chemistry. 19, 34, p. 6194-6200
  Research output: Contribution to journal › Article › peer-review

2008

• PublishedCyclisation reactions of bis-protected guanidines.
  Albrecht, C., Barnes, S., Bockemeier, H., Davies, D., Dennis, M., Evans, D. M., Fletcher, M. D., Jones, I., Leitmann, V., Murphy, P. J., Rowles, R., Nash, R., Stephenson, R. A., Horton, P. N. & Hursthouse, M. B., 1 Jan 2008, In: Tetrahedron Letters. 49, 1, p. 185-188
  Research output: Contribution to journal › Article › peer-review
• PublishedNickel dithiolenes containing pendant thiophene units: precursors to dithiolene-polythiophene hybrid materials.
  Anjos, T., Roberts-Bleming, S. J., Charlton, A., Robertson, N., Mount, A. R., Coles, S. J., Hursthouse, M. B., Kalaji, M. & Murphy, P. J., 1 Jan 2008, In: Journal of Materials Chemistry. 18, 4, p. 475-483
  Research output: Contribution to journal › Article › peer-review

2007

• PublishedSynthetic studies towards ptilomycalin A: total synthesis of crambescidin 359
  Moore, C. G., Murphy, P. J., Williams, H. L., McGown, A. T. & Smith, N. K., 19 Nov 2007, In: Tetrahedron. 63, 47, p. 11771-11780
  Research output: Contribution to journal › Article › peer-review

2006

• PublishedA convenient preparation of (1R, 2S, 7S, 8R)-3,5-diaza-2,7-dimethyl-1,8-diphenyloctan-1,8-diol and its enantiomer
  Murphy, P. J., Pinato, S., Thomas, D. & Oller-Lopez, J. L., 1 Sept 2006, In: Chemical and Pharmaceutical Bulletin. 54, 9, p. 1331-1332
  Research output: Contribution to journal › Article › peer-review
• PublishedAntimalarial activity of crambescidin 800 and synthetic analogues against liver and blood stage of Plasmodium sp.
  Lazaro, J. E., Nitcheu, J., Mahmoudi, N., Ibana, J. A., Mangalindan, G. C., Black, G. P., Howard-Jones, A. G., Moore, C. G., Thomas, D. A., Mazier, D., Ireland, C. M., Concepcion, G. P., Murphy, P. J. & Diquet, B., 1 Oct 2006, In: Journal of Antibiotics. 59, 9, p. 583-590
  Research output: Contribution to journal › Article › peer-review

2004

• PublishedOrganophosphorus Reagents.
  Murphy, P. J. (Editor), 1 Jan 2004, 2004 ed. Oxford University Press.
  Research output: Book/Report › Book

2003

• PublishedA synthesis of crambescidin 359.
  Moore, C. G., Murphy, P. J., Williams, H. L., McGown, A. T. & Smith, N. K., 6 Jan 2003, In: Tetrahedron Letters. 44, 2, p. 251-254
  Research output: Contribution to journal › Article › peer-review
• PublishedIntramolecular guanidine epoxide ring opening reactions.
  Dennis, M., Hall, L. M., Murphy, P. J., Thornhill, A. J., Nash, R., Winters, A. L., Hursthouse, M. B., Light, M. E. & Horton, P., 7 Apr 2003, In: Tetrahedron Letters. 44, 15, p. 3075-3080
  Research output: Contribution to journal › Article › peer-review
• PublishedSynthesis and applications of C2 Symmetric Guanidine Bases.
  Allingham, M. T., Howard-Jones, A., Murphy, P. J., Thomas, D. A. & Caulkett, P. W., 24 Nov 2003, In: Tetrahedron Letters. 44, 48, p. 8677-8680
  Research output: Contribution to journal › Article › peer-review
• PublishedSynthesis and Photoreactivity of 4,5-Dithienyl[1,3]dithiol-2-ones.
  Robert-Bleming, S. J., Davies, G. L., Kalaji, M., Murphy, P. J., Celli, A. M., Donati, D. & Ponticelli, F., 1 Aug 2003, In: Journal of Organic Chemistry. 68, 18, p. 7115-7118
  Research output: Contribution to journal › Article › peer-review

2002

• Published4,4-Dimethyl-3,5,8,10-tetraoxatricyclo[5.2.1.0(2,6)] decane.
  Light, M. E., Murphy, P. J., Brown, P. M. & Hursthouse, M. B., 1 May 2002, In: Acta Crystallographica Section E: Structure Reports Online. 58, 5, p. o560-o561
  Research output: Contribution to journal › Article › peer-review
• PublishedEpoxide rearrangements using dilithiated aminoalcohols as chiral bases.
  Brookes, P. C., Milne, D. J., Murphy, P. J. & Spolaore, B., 3 Jun 2002, In: Tetrahedron. 58, 23, p. 4675-4680
  Research output: Contribution to journal › Article › peer-review
• PublishedEthyl 3-(diphenylphosphinoyl)-3-phenylpropionate.
  Light, M. E., Murphy, P. J., Hancock, P. & Hursthouse, M. B., 1 Sept 2002, In: Acta Crystallographica Section E: Structure Reports Online. 58, 9, p. o990-o991
  Research output: Contribution to journal › Article › peer-review
• PublishedIntramolecular Wittig reactions with esters utilising triphenylphosphine and dimethyl acetylenedicarboxylate
  Evans, L. A., Griffiths, K. E., Guthmann, H. & Murphy, P. J., 7 Jan 2002, In: Tetrahedron Letters. 43, 2, p. 299-301
  Research output: Contribution to journal › Article › peer-review
• PublishedTandem Michael/Michael reactions mediated by phosphines or aryl thiolates.
  Brown, P. M., Kappel, N., Murphy, P. J., Coles, S. J. & Hursthouse, M. B., 25 Nov 2002, In: Tetrahedron. 43, 48, p. 8707-8710
  Research output: Contribution to journal › Article › peer-review
• PublishedTandem Micheal/Michael reactions mediated by phosphines or aryl thiolates.
  Brown, P. M., Kappel, N. & Murphy, P. J., 25 Nov 2002, In: Tetrahedron Letters. 43, 48, p. 8707-8710
  Research output: Contribution to journal › Article › peer-review

2001

• Published2-Ethyl 5-methyl 3-hydroxythiophene-2,5-dicarboxylate.
  Coles, S. J., Guthmann, H., Hursthouse, M. B. & Murphy, P. J., 1 Oct 2001, In: Acta Crystallographica Section E: Structure Reports Online. 57, 10, p. o976-o977
  Research output: Contribution to journal › Article › peer-review
• Published4,5,4 ' 5 '-Tetrakis(2-methyl-thiopen-3-yl)-[2,2 ']bi[[1,3]dithiolylidene]
  Gelbrich, T., Roberts-Bleming, S. J., Kalaji, M., Murphy, P. J. & Hursthouse, M. B., 1 Dec 2001, In: Acta Crystallographica Section E: Structure Reports Online. 57, 12, p. o1143-o1144
  Research output: Contribution to journal › Article › peer-review
• PublishedAssessing the scope of the tandem Michael/intramolecular aldol reaction mediated by secondary amines, thiols and phosphines
  Richards, E. L., Murphy, P. J., Dinon, F., Fratucello, S., Brown, P. M., Gelbrich, T. & Hursthouse, M. B., 3 Sept 2001, In: Tetrahedron. 57, 36, p. 7771-7784
  Research output: Contribution to journal › Article › peer-review
• PublishedOn the photoreactivity of 4,5-dithiophen-3-yl[1,3]dithiol-2-one. The first preparation of a thieno[3,4-c]dithiine
  Celli, A. M., Donati, D., Ponticelli, F., Roberts-Bleming, S. J., Kalaji, M. & Murphy, P. J., 1 Nov 2001, In: Organic Letters. 3, 22, p. 3573-3574
  Research output: Contribution to journal › Article › peer-review
• PublishedSynthesis and biological activity of analogues of ptilomycalin A.
  Black, G. P., Coles, S. J., Hizi, A., Howard-Jones, A. G., Hursthouse, M. B., McGown, A. T., Loya, S., Moore, C. G., Murphy, P. J., Smith, N. K. & Walshe, N. D., 7 May 2001, In: Tetrahedron Letters. 42, 19, p. 3377-3381
  Research output: Contribution to journal › Article › peer-review
• PublishedThe synthesis and biological activity of the marine metabolite cylindrospermopsin
  Murphy, P. J. & Thomas, C. W., 1 Sept 2001, In: Chemical Society Reviews. 30, 5, p. 303-312
  Research output: Contribution to journal › Article › peer-review

2000

• Published2 Synthetic methods. Part (iii) Heteroatom methods
  Murphy, P. J. & Thomas, D. A., 2000, In: Annual Reports on the Progress of Chemistry - Section B. 2000, 96, p. 39-63 25 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedHighly stereoselective conjugate additions of heteroaryl alkyl sulfoxides
  Casey, M., Gairns, R. S., Geraghty, G. M., Kelly, C. J., Murphy, P. J. & Walker, A. J., 2000, In: Synlett. 2000, 12, p. 1721-1724 4 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedLangmuir and Langmuir-Blodgett (LB) films of 4-dicyanomethylene,4H-cyclopenta[2,1-b,3,4-b?]dithiophene
  Riul, A., Taylor, D. M., Mills, C. A. & Murphy, P. J., May 2000, In: Thin Solid Films. 366, 1-2, p. 249-254 6 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedThe guanidine metabolites of Ptilocaulis spiculifer and related compounds; isolation and synthesis
  Heys, L., Moore, C. G. & Murphy, P. J., 2000, In: Chemical Society Reviews. 29, 1, p. 57-67 11 p.
  Research output: Contribution to journal › Article › peer-review

1999

• PublishedA synthetic approach to the plakortones
  Bittner, C., Burgo, A., Murphy, P. J., Sung, C. H. & Thornhill, A. J., 23 Apr 1999, In: Tetrahedron Letters. 40, 17, p. 3455-3456 2 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedIntramolecular Wittig reactions with lactones utilising triphenylphosphine and dimethyl acetylenedicarboxylate
  Heys, L., Murphy, P. J., Coles, S. J., Gelbrich, T. & Hursthouse, M. B., 24 Sept 1999, In: Tetrahedron Letters. 40, 39, p. 7151-7152 2 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedInvestigations into a low band gap, semiconducting polymer
  Mills, C. A., Taylor, D. M., Murphy, P. J., Dalton, C., Jones, G. W., Hall, L. M. & Hughes, A. V., Jun 1999, In: Synthetic Metals. 102, 1-3, p. 1000-1001 2 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedRecent synthetic applications of the non-classical wittig reaction
  Murphy, P. J. & Lee, S. E., 1999, In: Journal of the Chemical Society: Perkin Transactions 1. 21, p. 3049-3066 18 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedSpectroelectrochemistry of bridged dithienyl derived polymers
  Kalaji, M., Murphy, P. J. & Williams, G. O., May 1999, In: Synthetic Metals. 101, 1, p. 123
  Research output: Contribution to journal › Article › peer-review
• PublishedStudy of conducting polymers for use as redox supercapacitors
  Kalaji, M., Murphy, P. J. & Williams, G. O., Jun 1999, In: Synthetic Metals. 102, 1-3, p. 1360-1361 2 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedSynthesis of a novel C2-symmetric guanidine base
  Howard-Jones, A., Murphy, P. J. & Thomas, D. A., 15 Jan 1999, In: Journal of Organic Chemistry. 64, 3, p. 1039-1041 3 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedSynthesis of the left hand unit of batzelladine F; revision of the reported relative stereochemistry
  Black, G. P., Murphy, P. J., Thornhill, A. J., Walshe, N. D. A. & Zanetti, C., 21 May 1999, In: Tetrahedron. 55, 21, p. 6547-6554 8 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedSynthetic methods: Part (iv) Heteroatom methods
  Murphy, P. J., 1999, In: Annual Reports on the Progress of Chemistry - Section B. 1999, 95, p. 59-81 23 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedTandem Michael/intramolecular aldol reactions mediated by secondary amines, thiols and phosphines
  Dinon, F., Richards, E., Murphy, P. J., Hibbs, D. E., Hursthouse, M. B. & Malik, K. M. A., 16 Apr 1999, In: Tetrahedron Letters. 40, 16, p. 3279-3282 4 p.
  Research output: Contribution to journal › Article › peer-review

1998

• Published2 Synthetic methods: Part (iv) Heteroatom methods
  Murphy, P. J., 1998, In: Annual Reports on the Progress of Chemistry - Section B. 94, p. 51-75 25 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedA short synthetic route to the tricyclic guanidinium core of the batzelladine alkaloids
  Black, G. P., Murphy, P. J. & Walshe, N. D. A., Aug 1998, In: Tetrahedron. 54, 32, p. 9481-9488 8 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedDisparity in the tandem epoxide-allylic alcohol-[1,2]/[2,3]-Wittig rearrangement of cis- and trans-1-benzyloxy-3,4-epoxycyclopentane
  Brookes, P. C., Murphy, P. J., Sommer, K., Hibbs, D. E., Hursthouse, M. B. & Malik, K. M. A., 1998, In: Journal of the Chemical Society: Perkin Transactions 1. 12, p. 1899-1901 3 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedSpectroelectrochemical and electrical characterization of low bandgap polymers
  Beyer, R., Kalaji, M., Kingscote-Burton, G., Murphy, P. J., Pereira, V. M. S. C., Taylor, D. M. & Williams, G. O., 15 Jan 1998, In: Synthetic Metals. 92, 1, p. 25-31 7 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedSynthesis, electrochemical properties and electropolymerization studies on 3-thienyl substituted tetrathiafulvalenes. Single-crystal X-ray structure of 4,4?,5,5?-tetrakis-(3-thienyl)-tetrathiafulvalene
  Charlton, A., Kalaji, M., Murphy, P. J., Salmaso, S., Underhill, A. E., Williams, G., Hursthouse, M. B. & Malik, K. M. A., 30 May 1998, In: Synthetic Metals. 95, 1, p. 75-78 4 p.
  Research output: Contribution to journal › Article › peer-review

1997

• PublishedAn intramolecular Baylis-Hillman reaction catalysed by secondary amines
  Black, G. P., Dinon, F., Fratucello, S., Murphy, P. J., Nielsen, M., Williams, H. L. & Walshe, N. D. A., 8 Dec 1997, In: Tetrahedron Letters. 38, 49, p. 8561-8564 4 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedConvenient synthesis of silyl substituted butadienes; a new route to silicon tethered intramolecular Diels-Alder reaction precursors
  Kahle, K., Murphy, P. J., Scott, J. & Tamagni, R., 1997, In: Journal of the Chemical Society: Perkin Transactions 1. 7, p. 997-1000
  Research output: Contribution to journal › Article › peer-review
• PublishedSynthesis and characterisation of low band gap polymers
  Gunatunga, S. R., Jones, G. W., Kalaji, M., Murphy, P. J., Taylor, D. M. & Williams, G. O., Jan 1997, In: Synthetic Metals. 84, 1-3, p. 973-974 2 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedSynthesis and epimerisation studies on carbohydrate derived bicyclic tetronate esters: The synthesis of furanofurans related to the cytotoxic metabolite goniofufurone
  Cagnolini, C., Ferri, M., Jones, P. R., Murphy, P. J., Ayres, B. & Cox, B., 31 Mar 1997, In: Tetrahedron. 53, 13, p. 4815-4820 6 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedThiophene-Functionalized TTF ?-Electron Donors as Potential Precursors to Conducting Polymers and Organic Metals: Synthesis, Properties, Structure, and Electropolymerization Studies
  Charlton, A., Underhill, A. E., Williams, G., Kalaji, M., Murphy, P. J., Malik, K. M. A. & Hursthouse, M. B., 1997, In: Journal of Organic Chemistry. 62, 10, p. 3098-3102 5 p.
  Research output: Contribution to journal › Article › peer-review

1996

• Published4,4′,5,5′-Tetrakis(2-thienyl)tetrathiafulvalene [TT-TTF]: synthesis and first X-ray crystal structure of a thiophene-substituted TTF electron donor
  Charlton, A., Underhill, A. E., Williams, G., Kalaji, M., Murphy, P. J., Hibbs, D. E., Hursthouse, M. B. & Malik, K. M. A., 1996, In: Chemical Communications. 1996, 21, p. 2423-2424 2 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedBiomimetic model studies towards ptilomycalin A
  Murphy, P. J., Williams, H. L., Hibbs, D. E., Hursthouse, M. B. & Malik, K. M. A., 10 Jun 1996, In: Tetrahedron. 52, 24, p. 8315-8332 18 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedCrystallographic evidence for the proposed host behaviour of ptilomycalin A
  Murphy, P. J., Williams, H. L., Hibbs, D. E., Hursthouse, M. B. & Abdul Malik, K. M., 1996, In: Chemical Communications. 3, p. 445-447 3 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedShort synthesis of the furanofuran sub-unit of the toxin erythroskyrine
  Rossin, R., Jones, P. R., Murphy, P. J. & Worsley, W. R., 1996, In: Journal of the Chemical Society: Perkin Transactions 2. 12, p. 1323-1325 3 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedSynthesis and characterization of low band gap polymers
  Gunatunga, S. R., Jones, G. W., Kalaji, M., Murphy, P. J., Taylor, D. M. & Williams, G. O., 1996, In: IEE Colloquium (Digest). 242
  Research output: Contribution to journal › Article › peer-review

1994

• PublishedMichael and substitution reactions of bicyclic tetronic, tetramic and thiotetronic esters
  Bertucco, A., Brennan, J., Fachini, M., Kluge, S., J. Murphy, P., Pasutto, F., Signorini, R. & Lloyd Williams, H., 1994, In: Tetrahedron. 50, 27, p. 8237-8252 16 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedPreparation of 2,3-disubstituted-4,5-dihydrothiophenes and thiophenes using the intramolecular non-classical wittig reaction of thiolcarboxylates
  Chatterjee, P., Murphy, P. J., Pepe, R. & Shaw, M., 1994, In: Journal of the Chemical Society, Perkin Transactions 1. 17, p. 2403-2405 3 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedSynthesis of a pentacyclic model of ptilomycalin A
  Murphy, P. J. & Williams, H. L., 1994, In: Journal of the Chemical Society, Chemical Communications. 7, p. 819-820 2 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedSynthetic studies towards ptilomycalin A using a biomimetic approach
  Murphy, P. J., Williams, H. L., Hursthouse, M. B. & Malik, K. M. A., 1994, In: Journal of the Chemical Society, Chemical Communications. 1, p. 119-120 2 p.
  Research output: Contribution to journal › Article › peer-review

1993

• PublishedDilithiated aminoalcohols as homochiral bases
  Milne, D. & Murphy, P. J., 1993, In: Journal of the Chemical Society, Chemical Communications. 10, p. 884-886 3 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedSubstitution and Michael reactions of bicyclic tetronic, tetramic and thiotetronic esters
  Bertucco, A., Brennan, J., Fachini, M., Kluge, S., Murphy, P. J., Pasutto, F., Signorini, R. & Williams, H. L., 1993, In: Journal of the Chemical Society, Perkin Transactions 1. 16, p. 1831-1833 3 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedThe total synthesis of Goniofufurone
  Murphy, P. J. & Dennison, S. T., 23 Jul 1993, In: Tetrahedron. 49, 30, p. 6695-6700 6 p.
  Research output: Contribution to journal › Article › peer-review

1992

• PublishedA novel stereoselective route to ?-butyrolactones
  Casey, M., Manage, A. C. & Murphy, P. J., 11 Feb 1992, In: Tetrahedron Letters. 33, 7, p. 965-968 4 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedA synthesis of goniofufurone
  Murphy, P. J., 1992, In: Journal of the Chemical Society, Chemical Communications. 16, p. 1096-1097 2 p.
  Research output: Contribution to journal › Article › peer-review

1990

• PublishedAllylsilanes in organic synthesis; An approach to the stereoselective synthesis of units for natural product synthesis
  Murphy, P. J. & Procter, G., 1990, In: Tetrahedron Letters. 31, 7, p. 1059-1062 4 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedAllylsilanes in organic synthesis; convenient preparation of synthetic intermediates by catalytic hydrosilation of acetylenic alcohols
  Murphy, P. J., Spencer, J. L. & Procter, G., 1990, In: Tetrahedron Letters. 31, 7, p. 1051-1054 4 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedAllylsilanes in organic synthesis; stereoselective preparation and reactions of functionalised β,γ-epoxysilanes
  Murphy, P. J., Russell, A. T. & Procter, G., 1990, In: Tetrahedron Letters. 31, 7, p. 1055-1058 4 p.
  Research output: Contribution to journal › Article › peer-review

1988

• PublishedA phosphorane mediated synthesis of tetronic, thiotetronic and tetramic lactones
  Brennan, J. & Murphy, P. J., 1988, In: Tetrahedron Letters. 29, 17, p. 2063-2065 3 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedEpoxy-silanes in organic synthesis
  Procter, G., Russell, A. T., Murphy, P. J., Tan, T. S. & Mather, A. N., 1988, In: Tetrahedron. 44, 13, p. 3953-3973 21 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedThe Wittig olefination reaction with carbonyl compounds other than aldehydes and ketones
  Murphy, P. J. & Brennan, J., 1988, In: Chemical Society Reviews. 17, p. 1-30 30 p.
  Research output: Contribution to journal › Article › peer-review

1987

• PublishedStereoselective aldol reactions via titanium enolates
  Murphy, P. J., Procter, G. & Russell, A. T., 1987, In: Tetrahedron Letters. 28, 18, p. 2037-2039 3 p.
  Research output: Contribution to journal › Article › peer-review

• KESS II PhD project with Phytovation Ltd BUK255

  01/06/2016 – 01/08/2022 (Finished)

• Total synthesis of the cylindrospermopsin alkaloids

  31/07/2012 – 21/08/2015 (Finished)

• Application of the quinone prodrug delivery system to guanidines

  01/10/2008 – 09/03/2012 (Finished)

• Novel Guanidine & Heterocyclic Materials

  01/09/2006 – 31/12/2009 (Finished)

Not averse to the occasional game of bridge or snooker or walking whilst catching up with a podcast.