2023

• PublishedSelective Killing of BRCA2-Deficient Ovarian Cancer Cells via MRE11 Blockade
  Alblihy , A., Ali , R., Algethami, M., Ritchie, A. A., Shoqafi, A., Alqahtani, S., Mesquita, K. A., Toss, M. S., Ordóñez-Morán , P., Jeyapalan, J. N., Dekker , L., Salerno, M., Hartsuiker, E., Grabowska , A. M., Rakha, E. A., Mongan, N. P. & Madhusudan, S., 30 Jun 2023, In: International journal of molecular sciences. 24, 13
  Research output: Contribution to journal › Article › peer-review

2020

• PublishedData presenting the synthesis of three novel stimuli responsive hyperbranched polymers synthesised via RAFT polymerisation and the bio conjugation of folic acid
  Blackburn, C., Tai, H., Salerno, M., Wang, X., Senan, C., Ratcliffe, I., Hartsuiker, E. & Wang, W., Feb 2020, In: Data in Brief. 28, 104861.
  Research output: Contribution to journal › Article › peer-review
• PublishedMre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication
  Böckemeier, L., Kraehenbuehl, R., Keszthelyi, A., Gasasira, M. U., Vernon, E., Beardmore, R., Broberg Vågbø, C., Chaplin, D., Collins, S., Krokan, H. E., Lambert, S. A. E., Paisz, B. & Hartsuiker, E., 29 May 2020, In: Science Advances. 6, 22, 9 p., eaaz4126.
  Research output: Contribution to journal › Article › peer-review

2019

• PublishedFolic acid and rhodamine labelled pH responsive hyperbranched polymers: Synthesis, characterization and cell uptake studies
  Blackburn, C., Tai, H., Salerno, M., Wang, X., Hartsuiker, E. & Wang, W., Nov 2019, In: European Polymer Journal. 120, 109259.
  Research output: Contribution to journal › Article › peer-review

2018

• PublishedGenetic Interaction Score (S-Score) Calculation, Clustering, and Visualization of Genetic Interaction Profiles for Yeast.
  Roguev, A., Ryan, C. J., Xu, J., Colson, I., Hartsuiker, E. & Krogan, N., Feb 2018, In: Cold Spring Harbor Protocols. 2018, 2
  Research output: Contribution to journal › Article › peer-review
• PublishedGenetic Interaction Screens in Schizosaccharomyces pombe Using the Pombe Epistasis Mapper (PEM) System and a Manual Colony Replicator.
  Colson, I. & Hartsuiker, E., Feb 2018, In: Cold Spring Harbor Protocols. 2018, 2
  Research output: Contribution to journal › Article › peer-review
• PublishedHigh-Throughput Quantitative Genetic Interaction Mapping in the Fission Yeast Schizosaccharomyces pombe.
  Roguev, A., Ryan, C. J., Hartsuiker, E. & Krogan, N. J., Feb 2018, In: Cold Spring Harbor Protocols. 2018, 2, p. 75-81 7 p.
  Research output: Contribution to journal › Article › peer-review

2017

• PublishedDeoxynucleoside Salvage in Fission Yeast Allows Rescue of Ribonucleotide Reductase Deficiency but Not Spd1-Mediated Inhibition of Replication
  Fleck, O., Fahnøe, U., Løvschal, K. V., Gasasira Uwamahoro, M.-F., Marinova, I. N., Kragelund, B. B., Carr, A. M., Hartsuiker, E., Holmberg, C. & Nielsen, O., 25 Apr 2017, In: Genes. 8, 5, 14 p., 128.
  Research output: Contribution to journal › Article › peer-review

2015

• PublishedThe DNA-Binding Domain of S-pombe Mrc1 (Claspin) Acts to Enhance Stalling at Replication Barriers
  Zech, J., Godfrey, E. L., Masai, H., Hartsuiker, E. & Dalgaard, J. Z., 22 Jul 2015, In: PLoS ONE. 10, 7
  Research output: Contribution to journal › Article › peer-review
• PublishedUV induced ubiquitination of the yeast Rad4-Rad23 complex promotes survival by regulating cellular dNTP pools
  Zhou, Z., Humphryes, N., van Eijk, P., Waters, R., Yu, S. R., Kraehenbuehl, R., Hartsuiker, E. & Reed, S. H., 6 Jul 2015, In: Nucleic Acids Research. 43, 15, p. 7360-7370
  Research output: Contribution to journal › Article › peer-review

2011

• PublishedDetection of covalent DNA-bound Spo11 and topoisomerase complexes
  Hartsuiker, E. & Tsubouchi, H. (Editor), 28 Apr 2011, DNA recombination: Methods and Protocols. Springer Science and Business Media LLC, p. 65-77
  Research output: Chapter in Book/Report/Conference proceeding › Chapter

2010

• PublishedCollaborative Action of Brca1 and CtIP in Elimination of Covalent Modifications from Double-Strand Breaks to Facilitate Subsequent Break Repair
  Nakamura, K., Kogame, T., Oshiumi, H., Shinohara, A., Sumitomo, Y., Agama, K., Pommier, Y., Tsutsui, K. M., Tsutsui, K., Hartsuiker, E., Ogi, T., Takeda, S. & Taniguchi, Y., 22 Jan 2010, In: PLOS Genetics. 6, 1
  Research output: Contribution to journal › Article › peer-review
• PublishedTopoisomerase I regulates open chromatin and controls gene expression in vivo
  Durand-Dubief, M., Persson, J., Norman, U., Hartsuiker, E. & Ekwall K., [. V., 7 Jul 2010, In: EMBO Journal. 29, 13, p. 2126 - 2134
  Research output: Contribution to journal › Article › peer-review

2009

• PublishedA supramodular FHA/BRCT-Repeat architecture mediates Nbs1 adaptor function in response to DNA damage.
  Lloyd, J., Chapman, J. R., Clapperton, J. A., Haire, L. F., Hartsuiker, E., Li, J., Carr, A. M., Jackson, S. P. & Smerdon, S. J., 2 Oct 2009, In: Cell. 139, 1, p. 100-111
  Research output: Contribution to journal › Article › peer-review
• PublishedCtp1CtIP and Rad32Mre11 nuclease activity are required for Rec12Spo11 removal, but Rec12Spo11 removal is dispensable for other MRN-dependent meiotic functions
  Hartsuiker, E., Mizuno, K., Molnar, M., Kohli, J., Ohta, K. & Carr, A. M., Apr 2009, In: Molecular and Cellular Biology. 29, 7, p. 1671-1681 11 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedDistinct Requirements for the Rad32Mre11 Nuclease and Ctp1CtIP in the Removal of Covalently Bound Topoisomerase I and II from DNA
  Hartsuiker, E., Neale, M. J. & Carr, A. M., 16 Jan 2009, In: Molecular Cell. 33, 1, p. 117-123
  Research output: Contribution to journal › Article › peer-review
• PublishedScreening a genome-wide S.pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.
  Deshpande, G. P., Hayles, J., Hoe, K. L., Kim, D. U., Park, H. O. & Hartsuiker, E., 1 May 2009, In: DNA Repair. 8, 5, p. 672-679
  Research output: Contribution to journal › Article › peer-review

2007

• PublishedTDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks
  El-Khamisy, S. F., Hartsuiker, E. & Caldecott, K. W., 1 Oct 2007, In: DNA Repair. 6, 10, p. 1485-95 11 p.
  Research output: Contribution to journal › Article › peer-review

2006

• PublishedDouble-strand break repair and homologous recombination in Schizosaccharomyces pombe
  Raji, H. & Hartsuiker, E., 15 Oct 2006, In: Yeast. 23, 13, p. 963-76 14 p.
  Research output: Contribution to journal › Article › peer-review

2005

• PublishedThe meiotic recombination hot spot ura4A in Schizosaccharomyces pombe
  Baur, M., Hartsuiker, E., Lehmann, E., Ludin, K., Munz, P. & Kohli, J., Feb 2005, In: Genetics. 169, 2, p. 551-61 11 p.
  Research output: Contribution to journal › Article › peer-review

2004

• PublishedRoles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot
  Yamada, T., Mizuno, K.-I., Hirota, K., Kon, N., Wahls, W. P., Hartsuiker, E., Murofushi, H., Shibata, T. & Ohta, K., 21 Apr 2004, In: EMBO Journal. 23, 8, p. 1792-803 12 p.
  Research output: Contribution to journal › Article › peer-review

2003

• PublishedA simple Cre-loxP method for chromosomal N-terminal tagging of essential and non-essential Schizosaccharomyces pombe genes
  Werler, P. J. H., Hartsuiker, E. & Carr, A. M., 30 Jan 2003, In: Gene. 304, p. 133-41 9 p.
  Research output: Contribution to journal › Article › peer-review

2002

• PublishedA 160-bp palindrome is a Rad50.Rad32-dependent mitotic recombination hotspot in Schizosaccharomyces pombe
  Farah, J. A., Hartsuiker, E., Mizuno, K.-I., Ohta, K. & Smith, G. R., May 2002, In: Genetics. 161, 1, p. 461-8 8 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedA single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway
  Marchetti, M. A., Kumar, S., Hartsuiker, E., Maftahi, M., Carr, A. M., Freyer, G. A., Burhans, W. C. & Huberman, J. A., 28 May 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 11, p. 7472-7 6 p.
  Research output: Contribution to journal › Article › peer-review

2001

• PublishedFission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repair
  Hartsuiker, E., Vaessen, E., Carr, A. M. & Kohli, J., 3 Dec 2001, In: EMBO Journal. 20, 23, p. 6660-71 12 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedNovel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe
  Manolis, K. G., Nimmo, E. R., Hartsuiker, E., Carr, A. M., Jeggo, P. A. & Allshire, R. C., 15 Jan 2001, In: EMBO Journal. 20, 1-2, p. 210-21 12 p.
  Research output: Contribution to journal › Article › peer-review

1999

• PublishedThe msh2 gene of Schizosaccharomyces pombe is involved in mismatch repair, mating-type switching, and meiotic chromosome organization
  Rudolph, C., Kunz, C., Parisi, S., Lehmann, E., Hartsuiker, E., Fartmann, B., Kramer, W., Kohli, J. & Fleck, O., Jan 1999, In: Molecular and Cellular Biology. 19, 1, p. 241-50 10 p.
  Research output: Contribution to journal › Article › peer-review

1998

• PublishedThe role of topoisomerase II in meiotic chromosome condensation and segregation in Schizosaccharomyces pombe
  Hartsuiker, E., Bähler, J. & Kohli, J., Oct 1998, In: Molecular Biology of the Cell. 9, 10, p. 2739-50 12 p.
  Research output: Contribution to journal › Article › peer-review

1994

• PublishedImmunocytochemical techniques applied to meiotic chromosomes
  Heyting, C., Dietrich, A. J., de Jong, J. H. & Hartsuiker, E., 1994, Chromosome Analysis Protocols. Gosden, J. R. (ed.). Vol. 29. p. 287-302 (Methods in Molecular Biology).
  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2022

• BU-IIA Funded Project: Genotoxicity of nucleoside analogue anti-viral and anti-cancer drugs

  The overall aim of the proposed research is to optimise and apply the range of assays we have developed to assess the genotoxic impact of some key anti-cancer (Gemcitabine) and anti-viral (Remdesivir and Molnupiravir) nucleoside analogues and publish this analysis as proof of principle and advertise the knowledge and expertise we have developed here in Wales. The proposed research involves a new collaboration between Bangor applicants and the recently established company Broken String Biosciences Ltd., which offers assays that are complementary to the assays we have been developing. In the long term, we believe there is significant potential for impact and commercial exploitation of our assays, e.g. by influencing requirements for genotoxic assessment of nucleoside analogue drugs and offering our expertise and novel assays as a commercial service for pharmaceutical companies to assess the on- and off-target effects of candidate nucleoside analogue drugs.

  Funding awarded through the Bangor University Innovation and Impact Award (Research Wales Innovation Funding). Value = £45,942

  1 Apr 2022 – 31 Mar 2023

  Activity: Other (Contributor)

• Exploiting synthetic lethality for cancer treatment: improving the activity and specificity of novel MRE11 inhibitors

  01/10/2025 – 15/10/2028 (Not started)

• Skills & Innovation voucher scheme - Beerobotics - Maxi

  01/05/2024 – 30/04/2025 (Finished)

• KESS II MRes with NWCR - BUK2E091

  01/10/2022 – 31/03/2024 (Finished)

• KESS II Mres with NWCR in Molecular Medicine BUK2231

  01/10/2022 – 31/03/2024 (Finished)

• KESS II MRes with North West Cancer Research BUK2222

  01/01/2021 – 31/01/2022 (Finished)

• KESS II MRes with North West Cancer Research BUK2224

  01/01/2021 – 31/03/2024 (Finished)

• KESS II Phd with Tenovus BUK2E004

  01/03/2020 – 31/03/2024 (Finished)

• KESS II MRes with North West Cancer Research- BUK2176

  01/10/2019 – 31/03/2024 (Finished)

• KESS II MRes with North West Cancer Research- BUK2175

  01/10/2018 – 01/08/2022 (Finished)

• KESS II MRes with North West Cancer Research- BUK2177

  01/10/2018 – 31/03/2024 (Finished)

• KESS II MRes with North West Cancer Research- BUK2178

  01/10/2018 – 31/03/2024 (Finished)

• KESS II Phd with Tenovus Cancer Care Ltd- BUK2128

  01/11/2017 – 31/03/2024 (Finished)

• Quantitative detection of DNA damage and nucleotides using LC/MS/MS

  01/01/2016 – 30/04/2016 (Finished)

• Genome-wide analysis of topoisomerase removal pathways

  01/09/2015 – 01/08/2019 (Finished)

• Wales Cancer Research Centre

  01/04/2015 – 01/08/2019 (Finished)

• Funding for equipment

  01/01/2015 – 30/09/2023 (Finished)

• Role of Mre11 nuclease activity in replication fork progression

  01/11/2014 – 31/10/2015 (Finished)

• Role of DNA repair in resisting treatment with Gemcitabine and other analogues

  01/01/2014 – 30/06/2017 (Finished)

• NWCR Research Fellow in Cancer Biology

  23/09/2013 – 01/08/2019 (Finished)

• The role of nucleotide excision repair in providing resistance to the nucleoside

  01/06/2013 – 10/11/2017 (Finished)

• The role of the Mre11 nuclease activity in resistance to cancer drugs

  01/12/2011 – 30/11/2013 (Finished)

• Genome-wide analysis of topoisomerase removal after camptothecin treatment

  01/10/2011 – 31/12/2014 (Finished)

• The NISCHR Cancer Genetics Biomedical Research Unit

  01/03/2011 – 01/08/2022 (Finished)

• Identification and analysis of DNA repair mechanisms that contribute to resistance against nucleoside analogues

  01/10/2010 – 30/09/2014 (Finished)

• Analysis of MRN-dependent and -independent topoisomerase removal mechanisms: implications for resistance against camptothecin and etoposide derivatives

  01/09/2010 – 31/08/2016 (Finished)