Molecular Modelling of GPCRs and membrane-bound receptors. Computer-aided drug design.

2018

• PublishedAssessing GPCR homology models constructed from templates of various transmembrane sequence identities: Binding mode prediction and docking enrichment
  Loo, J. S. E., Emtage, A. L., Ng, K. W., Yong, A. S. J. & Doughty, S. W., 2018, In: Journal of Molecular Graphics and Modelling. 80, p. 38-47 10 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedSynthesis and evaluation of nuciferine and roemerine enantiomers as 5-HT2 and α1 receptor antagonists
  Heng, H. L., Chee, C. F., Chin, S. P., Ouyang, Y., Wang, H., Buckle, M. J. C., Herr, D. R., Paterson, I. C., Doughty, S. W., Abd Rahman, N. & Chung, L. Y., 2018, In: MedChemComm. 9, 3, p. 576-582 7 p.
  Research output: Contribution to journal › Article › peer-review

2012

• PublishedHomology modeling of the human 5-HT1A, 5-HT2A, D1, and D2 receptors: Model refinement with molecular dynamics simulations and Docking evaluation
  Yap, B. K., Buckle, M. J. C. & Doughty, S. W., 2012, In: Journal of Molecular Modeling. 18, 8, p. 3639-3655 17 p.
  Research output: Contribution to journal › Article › peer-review

2007

• PublishedCrystallization and preliminary X-ray characterization of the Bacillus amyloliquefaciens YwrO enzyme
  AbuKhader, M. M., Heap, J., De Matteis, C. I., Doughty, S. W., Minton, N. & Paoli, M., 2007, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 63, 9, p. 746-750 5 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedInhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles
  Banks, E. C., Doughty, S. W., Toms, S. M., Wheelhouse, R. T. & Nicolaou, A., 2007, In: Febs Journal. 274, 1, p. 287-299 13 p.
  Research output: Contribution to journal › Article › peer-review

2006

• PublishedThe influence of l-amino acid molecular structure on the phase transition temperature of hydroxypropyl methylcellulose
  Richardson, J. C., Foster, C. S., Doughty, S. W., Burton, J. S., MacRae, R. J. & Melia, C. D., 2006, In: Carbohydrate Polymers. 65, 1, p. 22-27 6 p.
  Research output: Contribution to journal › Article › peer-review

2002

• PublishedThe application of molecular modelling to the interpretation of inverse gas chromatography data: Journal of Chromatography A
  Grimsey, I. M., Osborn, J. C., Doughty, S. W., York, P. & Rowe, R. C., 2002, p. 49-57. 9 p.
  Research output: Contribution to conference › Paper › peer-review

1998

• PublishedA molecular mechanism for toxin block in N-type calcium channels
  Doughty, S. W., Blaney, F. E., Orlek, B. S. & Richards, W. G., 1998, In: Protein Engineering. 11, 2, p. 95-99 5 p.
  Research output: Contribution to journal › Article › peer-review

1997

• PublishedTheoretical studies of the intramolecular mechanism for the alkoxyphosphazene to alkoxyphosphazane transformation
  Doughty, S. W., Fitzsimmons, B. W. & Reynolds, C. A., 1997, In: Journal of the Chemical Society - Dalton Transactions. 3, p. 367-370 4 p.
  Research output: Contribution to journal › Article › peer-review

2024

• Public, Patient and Stakeholder input in to New Pharmacy Degree in North Wales

  A series of workshops and drop-in sessions for Pharmacists, patients, the public and other stakeholders to engage in discussion on requirements for the new Pharmacy degree being planned at Bangor University. Multiple in-person events were held across North Wales (at the 3 main hospitals in BCUHB and at other locations in the East, Central and West regions of BCUHB). This included Wrexham, through to Tremadog. Also an email survey was distributed to Llais (patient advocacy group). Funded by the BU Community Fund.

  10 Apr 2024 – 30 Jun 2024

  Activity: Other (Contributor)