Overview
Vanessa Marensi holds a lectureship in Pharmacology at the North Wales Medical School. Her research primarily focuses on overcoming drug resistance in cancer, while also exploring other areas of cancer pharmacology. Her work includes investigations into:
- Molecular adaptations resulting from drug exposure.
- The impact of clinically relevant mutations on drug response.
- Mechanisms by which changes in fatty acid homeostasis promote the development of pathologies via protein fatty acylation.
- Non-canonical functions of enzymes and other proteins.
- The therapeutic potential and mechanisms of action of novel synthetic and semi-synthetic molecules derived from natural sources.
Ongoing studies:
Elucidating the mechanisms of drug resistance resulting from exposure to FLT3 kinase inhibitors, given that FLT3 kinase activity and mutations in the corresponding gene contribute to relapse in patients with acute myeloid leukaemia.
Qualifications
- FHEA
University of Liverpool, - BSc: Pharmacy
UNIVALI, - MSc: Biomedical Data
Universita degli studi di Verona, - PhD: Physiology
University of Alberta,
Teaching and Supervision
Undergraduate Courses:
MSE-3026: Medical Pharmacology
MSE-3029: Pharmacogenomics
Postgraduate Courses:
MSE-4087: Pharmacogenomics and Stratified Healthcare
Postgraduate Project Opportunities
Enquiries from enthusiastic prospective PhD students are welcome. Projects across our research interests are available.
Publications
2025
- PublishedIn search of a targetable immune profile for acute myeloid leukemia
Kaur, G., Ghaffari, N., Kalakonda, N., Grey, W. & Marensi, V., 14 Nov 2025, Advances in Cancer Research. Vol. 168. p. 159-194 36 p. (Advances in Cancer Research).
Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review