Skip to main content
Home

Information for:

  • Alumni
  • Applicants
  • Current Students
  • Staff
  • Parents
  • Job Vacancies
  • Covid-19
  • Cymraeg
My country:

Main Menu

    • Study Options
      • Study Home
      • Why Study at Bangor?
      • Undergraduate Study
      • Postgraduate Taught Study
      • Postgraduate Research
      • Executive Education
      • Part-time Courses
      • January Start Courses
      • Degree Apprenticeships
      • Study Abroad
      • Work Experience
    • Study Advice
      • Apply
      • Already Applied?
      • Fees and Finances
      • Scholarships and Bursaries
      • Get Ready for University
      • Widening Access
    • Explore Bangor
      • Open Days and Visits
      • Virtual Student Experience
      • Magical Bangor

    Find a Course

    Order a Course Guide

    Open Days

    Clearing

    • Student Life
      • Student Life Home
      • Bangor and the Area
      • Social Life and Entertainment
      • Student Accommodation
      • Clubs and Societies
      • Sport
      • Virtual Student Experience
      • Videos and Vlogs
    • Your Experience at Bangor
      • Student Support
      • Skills and Employability
      • Study or Work Abroad
      • Fees and Finances

    Student Profiles

    Student Videos and Vlogs

    Welcome 2022

    • Choose Bangor
      • International Home
      • Why Bangor?
      • Location
      • Accommodation
      • Student Support
      • Contact Us
      • Bangor University's China website
    • Apply
      • Entry Requirements
      • Tuition Fees and Scholarships
      • How to Apply
      • Already Applied
      • Study Abroad
      • Exchanges
      • Worldwide Partners

    Country Specific Information

    Bangor University International College

    Find a Course

    Clearing 2023

    • Research
      • Research Home
      • About Our Research
      • Research in our Academic Schools
      • Research Institutes and Centres
      • Research Portal
      • Integrated Research and Impact Support (IRIS) Service
      • Energy
      • REF 2021
      • Research News
    • Postgraduate Research Opportunities
      • Postgraduate Research
      • Doctoral School
    • Events and Training Opportunities
      • Researcher Development
    • The University
      • About Us
      • Our Mission
      • Strategy 2030
      • Annual Report & Financial Statements
      • Our Location
      • Academic Schools and Colleges
      • Services and Facilities
      • Vice-Chancellor's Office
      • Working with Business
      • Working with the Community
      • Sustainability
      • Health and Wellbeing
      • Contact Us
    • Working for Us
      • Job Vacancies
    • University Management and Governance
      • Policies and Procedures
      • Slavery and Human Trafficking Statement
      • Management and Governance
    • University and the Community
      • Pontio
      • Sports Facilities
      • Conference Facilities
      • Places to Eat and Drink
      • Public Events
      • Widening Access
      • Services to Schools
    • Business Services
      • Business Services Home
    • Collaboration Hub
      • Collaboration Hub
    • Conferencing and Business Dining
      • Conferencing Facilities
      • Business Dining
    • Intellectual Property (IP) and Commercialisation
      • Intellectual Property (IP) and Commercialisation
    • News
      • Current News
      • Research News
      • Student News
    • Events
      • Events
    • Announcements
      • Flag Announcements
  • Open Days

    • Study Options
      • Study Home
      • Why Study at Bangor?
      • Undergraduate Study
      • Postgraduate Taught Study
      • Postgraduate Research
      • Executive Education
      • Part-time Courses
      • January Start Courses
      • Degree Apprenticeships
      • Study Abroad
      • Work Experience
    • Study Advice
      • Apply
      • Already Applied?
      • Fees and Finances
      • Scholarships and Bursaries
      • Get Ready for University
      • Widening Access
    • Explore Bangor
      • Open Days and Visits
      • Virtual Student Experience
      • Magical Bangor

    Find a Course

    Order a Course Guide

    Open Days

    Clearing

    • Student Life
      • Student Life Home
      • Bangor and the Area
      • Social Life and Entertainment
      • Student Accommodation
      • Clubs and Societies
      • Sport
      • Virtual Student Experience
      • Videos and Vlogs
    • Your Experience at Bangor
      • Student Support
      • Skills and Employability
      • Study or Work Abroad
      • Fees and Finances

    Student Profiles

    Student Videos and Vlogs

    Welcome 2022

    • Choose Bangor
      • International Home
      • Why Bangor?
      • Location
      • Accommodation
      • Student Support
      • Contact Us
      • Bangor University's China website
    • Apply
      • Entry Requirements
      • Tuition Fees and Scholarships
      • How to Apply
      • Already Applied
      • Study Abroad
      • Exchanges
      • Worldwide Partners

    Country Specific Information

    Bangor University International College

    Find a Course

    Clearing 2023

    • Research
      • Research Home
      • About Our Research
      • Research in our Academic Schools
      • Research Institutes and Centres
      • Research Portal
      • Integrated Research and Impact Support (IRIS) Service
      • Energy
      • REF 2021
      • Research News
    • Postgraduate Research Opportunities
      • Postgraduate Research
      • Doctoral School
    • Events and Training Opportunities
      • Researcher Development
    • The University
      • About Us
      • Our Mission
      • Strategy 2030
      • Annual Report & Financial Statements
      • Our Location
      • Academic Schools and Colleges
      • Services and Facilities
      • Vice-Chancellor's Office
      • Working with Business
      • Working with the Community
      • Sustainability
      • Health and Wellbeing
      • Contact Us
    • Working for Us
      • Job Vacancies
    • University Management and Governance
      • Policies and Procedures
      • Slavery and Human Trafficking Statement
      • Management and Governance
    • University and the Community
      • Pontio
      • Sports Facilities
      • Conference Facilities
      • Places to Eat and Drink
      • Public Events
      • Widening Access
      • Services to Schools
    • Business Services
      • Business Services Home
    • Collaboration Hub
      • Collaboration Hub
    • Conferencing and Business Dining
      • Conferencing Facilities
      • Business Dining
    • Intellectual Property (IP) and Commercialisation
      • Intellectual Property (IP) and Commercialisation
    • News
      • Current News
      • Research News
      • Student News
    • Events
      • Events
    • Announcements
      • Flag Announcements
  • Open Days

Information for:

  • Alumni
  • Applicants
  • Current Students
  • Staff
  • Parents
  • Job Vacancies
  • Covid-19
My country:

Search

Close

Breadcrumb

  • Cymraeg

Share this page:
  • Twitter
  • Facebook
  • LinkedIn

Professor Alexander Yakunin

Professor In Enzyme Discovery and Application

a.iakounine@bangor.ac.uk

+44 1248 388399

0000-0003-0813-6490

Professor Alexander Yakunin

View Professor Alexander Yakunin’s profile on the Bangor Research Portal

Additional Contact Information

Professor Alexander Yakunin (Iakounine)

Office: Thoday Building, room S25

Email: a.iakounine@bangor.ac.uk

Tel: 01248 388399

Research focus: enzyme discovery, enzymology, enzyme applications

Qualifications

  • PhD: Microbiology
    Winogradsky Institute of Microbiology, Moscow, 1987
  • MSc: Molecular biology
    Moscow State University, 1978

Postgraduate Project Opportunities

1. Novel extremophilic enzymes from environmental metagenomes and genomes; 2. Enzyme applications in bioremediation (plastics/microplastics recycling); 3. Enzyme applications in biocatalysis (biosynthesis of polymer precursors); 4. Novel CRISPR-associated enzymes.

Publications

2025

  • PublishedPolyesterase activity is widespread in the family IV carboxylesterases from bacteria
    Ma, H., Khusnutdinova, A. N., Lemak, S., Chernikova, T. N., Golyshina, O. V., Almendral, D., Ferrer, M., Golyshin, P. N. & Yakunin, A. F., 5 Jan 2025, In: Journal of Hazardous Materials. 481, p. 136540
    Research output: Contribution to journal › Article › peer-review
  • E-pub ahead of printStructural and Biochemical Insights into Lignin-Oxidizing Activity of Bacterial Peroxidases against Soluble Substrates and Kraft Lignin
    Choolaei, Z., Khusnutdinova, A. N., Skarina, T., Stogios, P., Diep, P., Lemak, S., Edwards, E. A., Savchenko, A. & Yakunin, A. F., 27 Mar 2025, (E-pub ahead of print) In: ACS Chemical Biology.
    Research output: Contribution to journal › Article › peer-review
  • E-pub ahead of printStructural and functional insights into extreme thermal stability and activity of two GH12 domains of a multidomain glycosidase from a hyperthermophilic euryarchaeon
    Zayulina , K. S., Frolov, E. N., Stracke, C., Klyukina, A. A., Khusnutdinova, A., Stogios, P., Skarina, T., Yakunin, A., Golyshin, P., Siebers, B., Shugaeva, T. E. & Kublanov, I. V., 2 Apr 2025, (E-pub ahead of print) In: Febs Journal.
    Research output: Contribution to journal › Article › peer-review

2024

  • PublishedAn Amino Acid Self-Regenerating Cell-Free Protein Synthesis System that Feeds on PLA Plastics, CO2, Ammonium, and α-ketoglutarate
    Nishikawa, S., Yu, W.-C., Jia, T. Z., He, M.-J., Khusnutdinova, A., Yakunin, A., Chiang, Y.-R., Fujishima, K. & Wang, P.-H., 17 May 2024, In: ACS Catalysis. 14, 10, p. 7696-7706
    Research output: Contribution to journal › Article › peer-review
  • PublishedA random mutagenesis screen enriched for missense mutations in bacterial effector proteins
    Urbanus, M. L., Zheng, T. M., Khusnutdinova, A. N., Banh, D., O'Connor Mount, H., Gupta, A., Stogios, P. J., Savchenko, A., Isberg, R. R., Yakunin, A. F. & Ensminger, A. W., 4 Sept 2024, In: G3: Genes, Genomes, Genetics. 14, 9
    Research output: Contribution to journal › Article › peer-review
  • PublishedBiochemical plasticity of the Escherichia coli CRISPR Cascade revealed by in vitro reconstitution of Cascade activities from purified Cas proteins
    Lemak, S., Brown, G., Makarova, K. S., Koonin, E. V. & Yakunin, A., 2024, In: Febs Journal. p. 1-18 18 p.
    Research output: Contribution to journal › Article › peer-review
  • E-pub ahead of printEnzyme cascades for in vitro and in vivo FMN prenylation and UbiD (de)carboxylase activation under aerobic conditions
    Khusnutdinova, A. N., Batyrova, K. A., Wang, P.-H., Flick, R., Edwards, E. A. & Yakunin, A. F., 16 Oct 2024, (E-pub ahead of print) In: Methods in Enzymology. 708, p. 151-173 23 p.
    Research output: Contribution to journal › Article › peer-review
  • PublishedModerately thermostable GH1 β-glucosidases from hyperacidophilic archaeon Cuniculiplasma divulgatum S5
    Khusnutdinova, A., Hai, T., Devlekar, S., Distaso, M., Kublanov, I. V., Skarina, T., Stogios, P., Savchenko, A., Ferrer, M., Golyshina, O., Yakunin, A. & Golyshin, P., Sept 2024, In: Fems Microbiology Ecology. 100, 9, fiae114.
    Research output: Contribution to journal › Article › peer-review
  • PublishedNi(II)-binding affinity of CcNikZ-II and its homologs: the role of the HH-prong and variable loop revealed by structural and mutational studies
    Diep, P., Stogios, P. J., Evdokimova, E., Savchenko, A., Mahadevan, R. & Yakunin, A. F., Jul 2024, In: Febs Journal. 291, 13, p. 2980-2993 14 p.
    Research output: Contribution to journal › Article › peer-review
  • E-pub ahead of printScaling-up Engineering Biology for Enhanced Environmental Solutions
    Hassard, F., Curtis, T. P., Dotro, G. C., Golyshin, P., Gutierrez, T., Heaven, S., Horsfall, L., Jefferson, B., Jones, D. L., Krasnogor, N., Kumar, V., Lea-Smith, D. J., Le Corre Pidou, K., Liu, Y., Lyu, T., McCarthy, R. R., McKew, B., Smith, C., Yakunin, A. & Yang, Z. & 2 others, Zhang, Y. & Coulon, F., 21 Jun 2024, (E-pub ahead of print) In: ACS synthetic biology. 13, 6, p. 1586-1588 3 p.
    Research output: Contribution to journal › Article › peer-review

2023

  • PublishedCRISPR-induced DNA reorganization for multiplexed nucleic acid detection
    Karlikow, M., Amalfitano, E., Yang, X., Doucet, J., Chapman, A., Sadat-Moussavi, P., Homme, P., Sutyrina, P., Chang, W., Lemak, S., Yakunin, A., Dolezal, A. G., Kelley, S., Foster, L., Harpur, B. & Pardee, K., 17 Mar 2023, In: Nature Communications. 14, 1, 1505.
    Research output: Contribution to journal › Article › peer-review
  • PublishedHarnessing extremophilic carboxylesterases for applications in polyester depolymerisation and plastic waste recycling
    Williams, G., Ma, H., Khusnutdinova, A., Yakunin, A. & Golyshin, P., Aug 2023, In: Essays in Biochemistry. 67, 4, p. 715-729 15 p., EBC20220255.
    Research output: Contribution to journal › Review article › peer-review
  • PublishedOne-pot chemo-enzymatic synthesis and one-step recovery of length-variable long-chain polyphosphates from microalgal biomass
    Lin, Y.-H., Nishikawa, S., Jia, T. Z., Yeh, F.-I., Khusnutdinova, A., Yakunin, A., Fujishima, K. & Wang, P.-H., 27 Oct 2023, In: Green Chemistry. 23
    Research output: Contribution to journal › Article › peer-review
  • PublishedQuantifying metal-binding specificity of CcNikZ-II from Clostridium carboxidivorans in the presence of competing metal ions
    Diep, P., Kell, B., Yakunin, A., Hilfinger, A. & Mahadevan, R., 1 Sept 2023, In: Analytical biochemistry. 676, 115182.
    Research output: Contribution to journal › Article › peer-review
  • PublishedStructural insights into hydrolytic defluorination of difluoroacetate by microbial fluoroacetate dehalogenases
    Khusnutdinova, A. N., Batyrova, K., Brown, G., Fedorchuck, T., Chai, Y. S., Skarina, T., Flick, R., Petit, A.-P., Savchenko, A., Stogios, P. & Yakunin, A., Oct 2023, In: Febs Journal. 290, 20, p. 4966-4983 18 p.
    Research output: Contribution to journal › Article › peer-review
  • PublishedThermophilic Carboxylesterases from Hydrothermal Vents of the Volcanic Island of Ischia Active on Synthetic and Biobased Polymers and Mycotoxins
    Distaso, M., Chernikova, T., Bargiela, R., Coscolín, C., Stogios, P. J., Gonzalez-Alfonso, J. L., Lemak, S., Khusnutdinova, A., Plou, F. J., Evdokimova, E., Savchenko, A., Lunev, E., Yakimov, M. M., Golyshina, O., Ferrer, M., Yakunin, A. & Golyshin, P., 28 Feb 2023, In: Applied and Environmental Microbiology. 89, 2, p. e0170422 20 p.
    Research output: Contribution to journal › Article › peer-review

2022

  • PublishedMetabolite Damage and Damage-Control in a Minimal Genome
    Haas, D., Thamm, A. M., Sun, J., Huang, L., Sun, L., Beaudoin, G. A. W., Wise, K. S., Lema-Ortiz, C., Bruner, S. D., Breuer, M., Luthey-Schutten, Z., Lin, J., Wilson, M. A., Brown, G., Yakunin, A., Kurilyak, I., Folz, J., Fiehn, O., Glass, J. I. & Hanson, A. D. & 2 others, Henry, C. S. & de Crecy-Lagard, V., 30 Aug 2022, In: mBio. e0163022.
    Research output: Contribution to journal › Article › peer-review
  • PublishedSystems engineering of Escherichia coli for n-butane production
    Liu, Y., Khusnutdinova, A., Chen, J., Crisante, D., Batyrova, K., Raj, K., Feigis, M., Shirzadi, E., Wang, X., Dorakhan, R., Wang, X., Stogios, P. J., Yakunin, A. F., Sargent, E. H. & Mahadevan, R., 1 Nov 2022, In: Metabolic Engineering. 74, p. 98-107 10 p.
    Research output: Contribution to journal › Article › peer-review

2021

  • PublishedLignin-oxidizing activity of bacterial laccases characterized using soluble substrates and polymeric lignin
    Choolaei, Z., Flick, R., Khusnutdinova, A., Edwards, E. A. & Yakunin, A. F., 10 Jan 2021, In: Journal of Biotechnology. 325, p. 128-137 10 p.
    Research output: Contribution to journal › Article › peer-review
  • PublishedStructural and biochemical insights into CRISPR RNA processing by the Cas5c ribonuclease SMU1763 from Streptococcus mutans
    Lemak, S., Serbanescu, M. A., Khusnutdinova, A. N., Ruszkowski, M., Beloglazova, N., Xu, X., Brown, G., Cui, H., Tan, K., Joachimiak, A., Cvitkovitch, D. G., Savchenko, A. & Yakunin, A., Nov 2021, In: Journal of Biological Chemistry. 297, 5, 101251.
    Research output: Contribution to journal › Article › peer-review

2020

  • PublishedA microplate screen to estimate metal-binding affinities of metalloproteins
    Diep, P., Mahadevan, R. & Yakunin, A. F., 15 Nov 2020, In: Analytical biochemistry. 609, p. 113836
    Research output: Contribution to journal › Article › peer-review
  • PublishedOne-pot biocatalytic transformation of adipic acid to 6-aminocaproic acid and 1,6-hexamethylenediamine using carboxylic acid reductases and transaminases
    Fedorchuk, T. P., Khusnutdinova, A. N., Evdokimova, E., Flick, R., Di Leo, R., Stogios, P. J., Savchenko, A. & Yakunin, A., 15 Jan 2020, In: Journal of the American Chemical Society. 142, 2, p. 1038-1048 11 p.
    Research output: Contribution to journal › Article › peer-review
  • PublishedProteome cold-shock response in the extremely acidophilic archaeon, Cuniculiplasma divulgatum
    Bargiela, R., Lanthaler, K., Potter, C., Ferrer, M., Yakunin, A., Paizs, B., Golyshin, P. & Golyshina, O., 19 May 2020, In: Microorganisms . 8, 5
    Research output: Contribution to journal › Article › peer-review

2019

  • PublishedPrenylated FMN: biosynthesis, purification, and Fdc1 activation
    Khusnutdinova, A. N., Xiao, J., Wang, P.-H., Batyrova, K., Flick, R., Edwards, E. & Yakunin, A., 2019, New Approaches for Flavin Catalysis. Palfey, B. A. (ed.). Elsevier, Vol. 620. p. 469-488 (Methods in Enzymology).
    Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
  • PublishedSite-directed mutagenesis and stability of the carboxylic acid reductase MAB4714 from Mycobacterium abscessus
    Fedorchuk, T. P., Khusnutdinova, A. N., Flick, R. & Yakunin, A., 10 Sept 2019, In: Journal of Biotechnology. 303, p. 72-79
    Research output: Contribution to journal › Article › peer-review

2018

  • PublishedBiosynthesis and activity of prenylated FMN cofactors
    Wang, P.-H., Khusnutdinova, A. N., Luo, F., Xiao, J., Nemr, K., Flick, R., Brown, G., Mahadevan, R., Edwards, E. & Yakunin, A., 17 May 2018, In: Cell Chemical Biology. 25, 5, p. 560-570
    Research output: Contribution to journal › Article › peer-review
  • PublishedDeterminants and prediction of esterase substrate promiscuity patterns
    Martínez-Martínez, M., Coscolín, C., Santiago, G., Chow, J., Stogios, P. J., Bargiela, R., Gertler, C., Navarro-Fernández, J., Bollinger, A., Thies, S., Méndez-García, C., Popovic, A., Brown, G., Chernikova, T., García-Moyano, A., Bjerga, G. E. K., Perez-Garcia, P., Hai, T., del Pozo, M. V. & Stokke, R. & 22 others, Steen, I. H., Cui, H., Xu, X., Nocek, B., Alcaide, M., Disasto, M., Mesa, V., Pelaez, A. I., Sanchez, J., Buchholz, P. C. F., Pleiss, J., Fernández-Guerra, A., Glockner, F. O., Golyshina, O., Yakimov, M. M., Savchenko, A., Jaeger, K.-E., Yakunin, A. F., Streit, W. R., Golyshin, P., Guallar, V. & Ferrer, M., 2018, In: ACS Chemical Biology. 13, 1, p. 225-234
    Research output: Contribution to journal › Article › peer-review
  • PublishedEngineering a short, aldolase based pathway for (R)-1,3-butanediol production in Escherichia coli
    Nemr, K., Muller, J., Joo, J. C., Gawand, P., Cjoudhary, R., Mendonca, B., Lu, S., Yu, X., Yakunin, A. & Mahadevan, R., 1 Jul 2018, In: Metabolic Engineering. 48, p. 13-24
    Research output: Contribution to journal › Article › peer-review
  • PublishedHeavy metal removal by bioaccumulation using genetically engineered microorganisms
    Diep, P., Mahadevan, R. & Yakunin, A., 29 Oct 2018, In: Frontiers in Bioengineering and Biotechnology. 6, 157.
    Research output: Contribution to journal › Article › peer-review
  • PublishedRelationships between Substrate Promiscuity and Chiral Selectivity of Esterases from Phylogenetically and Environmentally Diverse Microorganisms
    Coscolín, C., Martínez-Martínez, M., Chow, J., Bargiela, R., García-Moyano, A., Bjerga, G. E. K., Bollinger, A., Stokke, R., Steen, I. H., Golyshina, O., Yakimov, M. M., Jaeger, K.-E., Yakunin, A. F., Streit, W. R., Golyshin, P. & Ferrer, M., 5 Jan 2018, In: Catalysts. 8, 1, 10.
    Research output: Contribution to journal › Article › peer-review
  • PublishedScreening and Characterization of Novel Polyesterases from Environmental Metagenomes with High Hydrolytic Activity against Synthetic Polyesters
    Hajighasemi, M., Tchigvintsev, A., Nocek, B., Flick, R., Popovic, A., Hai, T., Khusnutdinova, A. N., Brown, G., Xu, X., Cui, H., Anstett, J., Chernikova, T., Bruls, T., Le Paslier, D., Yakimov, M. M., Joachimiak, A., Golyshina, O., Savchenko, A., Golyshin, P. & Edwards, E. A. & 1 others, Yakunin, A. F., 6 Nov 2018, In: Environmental Science and Technology. 52, 21, p. 12388-12401
    Research output: Contribution to journal › Article › peer-review
  • PublishedStructural Insights into Substrate Selectivity and Activity of Bacterial Polyphosphate Kinases
    Nocek, B. P., Khusnutdinova, A. N., Ruszkowski, M., Flick, R., Burda, M., Batyrova, K., Brown, G., Mucha, A., Joachimiak, A., Berlicki, L. & Yakunin, A. F., 2 Nov 2018, In: ACS Catalysis. 8, 11, p. 10746-10760
    Research output: Contribution to journal › Article › peer-review

2017

  • PublishedActivity screening of environmental metagenomic libraries reveals novel carboxylesterase families
    Popovic, A., Hai, T., Tchigvintsev, A., Hajighasemi, M., Nocek, B., Khusnutdinova, A. N., Brown, G., Glinos, J., Flick, R., Skarina, T., Chernikova, T., Yim, V., Bruls, T., Le Paslier, D., Yakimov, M. M., Joachimiak, A., Ferrer, M., Golyshina, O., Savchenko, A. & Golyshin, P. & 1 others, Yakunin, A. F., Mar 2017, In: Scientific Reports. 7, 44103, 44103.
    Research output: Contribution to journal › Article › peer-review
  • PublishedAlkene hydrogenation activity of enoate reductases for an environmentally benign biosynthesis of adipic acid
    Joo, J. C., Khusnutdinova, A. N., Flick, R., Kim, T., Bornscheuer, U. T., Yakunin, A. F. & Mahadevan, R., 1 Feb 2017, In: Chemical Science. 8, 2, p. 1406-1413
    Research output: Contribution to journal › Article › peer-review
  • PublishedMetabolic and evolutionary patterns in the extremely acidophilic archaeon Ferroplasma acidiphilum YT
    Golyshina, O., Hai, T., Reva, O. N., Lemak, S., Yakunin, A. F., Goesmann, A., Nechitaylo, T. Y., LaCono, V., Smedile, F., Slesarev, A., Rojo, D., Barbas, C., Ferrer, M., Yakimov, M. M. & Golyshin, P., 16 Jun 2017, In: Scientific Reports. 7, 3682.
    Research output: Contribution to journal › Article › peer-review
  • PublishedSAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia
    Schneider, C., Oellerich, T., Baldauf, H.-M., Schwarz, S.-M., Thomas, D., Flick, R., Bohnenberger, H., Kaderali, L., Stegmann, L., Cremer, A., Martin, M., Lohmeyer, J., Michaelis, M., Hornung, V., Schliemann, C., Berdel, W. E., Hartmann, W., Wardelmann, E., Comoglio, F. & Hansmann, M.-L. & 7 others, Yakunin, A. F., Geisslinger, G., Stroebel, P., Ferreiros, N., Serve, H., Keppler, O. T. & Cinatl, J. J., Feb 2017, In: Nature Medicine. 23, 2, p. 250-255
    Research output: Contribution to journal › Article › peer-review

2016

  • PublishedA family of metal-dependent phosphatases implicated in metabolite damage-control
    Huang, L., Khusnutdinova, A., Nocek, B., Brown, G., Xu, X., Cui, H., Petit, P., Flick, R., Zallot, R., Balmant, K., Ziemak, M. J., Shanklin, J., de Crecy-Lagard, V., Fiehn, O., Gregory, J. F. ,. I., Joachimiak, A., Savchenko, A., Yakunin, A. F. & Hanson, A. D., Aug 2016, In: Nature Chemical Biology. 12, 8, p. 621-627
    Research output: Contribution to journal › Article › peer-review
  • PublishedBiochemical and structural insights into enzymatic depolymerization of polylactic acid and other polyesters by microbial carboxylesterases
    Hajighasemi, M., Nocek, B. P., Tchigvintsev, A., Brown, G., Flick, R., Xu, X., Cui, H., Hai, T., Joachimiak, A., Golyshin, P., Savchenko, A., Edwards, E. A. & Yakunin, A. F., 18 Apr 2016, In: Biomacromolecules. 17, 6, p. 2027-2039
    Research output: Contribution to journal › Article › peer-review

2015

  • PublishedCRISPR RNA binding and DNA target recognition by purified Cascade complexes from Escherichia coli
    Beloglazova, N., Kuznedelov, K., Flick, R., Datsenko, K. A., Brown, G., Popovic, A., Lemak, S., Semenova, E., Severinov, K. & Yakunin, A. F., Jan 2015, In: Nucleic Acids Research. 43, 1, p. 530-543
    Research output: Contribution to journal › Article › peer-review
  • PublishedDiversity of hydrolases from hydrothermal vent sediments of the Levante Bay, Vulcano Island (Aeolian archipelago) identified by activity-based metagenomics and biochemical characterization of new esterases and an arabinopyranosidase
    Placido, A., Hai, T., Ferrer, M., Chernikova, T. N., Distaso, M. A., Armstrong, D., Yakunin, A. F., Toshchakov, S. V., Yakimov, M. M., Kublanov, I. V., Golyshina, O., Pesole, G., Ceci, L. R. & Golyshin, P., 1 Dec 2015, In: Applied Microbiology and Biotechnology. 99, 23, p. 10031-10046
    Research output: Contribution to journal › Article › peer-review
  • PublishedIdentification and characterization of carboxyl esterases of gill chamber-associated microbiota in the deep-sea shrimp Rimicaris exoculata using functional metagenomics
    Alcaide, M., Tchigvinstsev, A., Martinez-Martinez, M., Popovic, A., Reva, O. N., Lafraya, A., Bargiela, R. N., Nechitaylo, T. Y., Matesanz, R., Cambon-Bonavita, M., Jebbar, M., Savchenko, A., Yakimov, M. M., Golyshina, O., Yakunin, A. F., Golyshin, P., Ferrer, M. & The MAMBA Consortium., [. V., 16 Jan 2015, In: Applied and Environmental Microbiology. 81, 6, p. 2125-2136
    Research output: Contribution to journal › Article › peer-review
  • PublishedMetagenomics as a tool for enzyme discovery: hydrolytic enzymes from marine-related metagenomes
    Popovic, A., Tchigvintsev, A., Tran, H., Chernikova, T. N., Golyshina, O. V., Yakimov, M. M., Golyshin, P. N. & Yakunin, A. F., 2015, Prokaryotic Systems Biology. Springer, p. 1-20 20 p.
    Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
  • PublishedThe environment shapes microbial enzymes: five cold-active and salt-resistant carboxylesterases from marine metagenomes
    Tchigvintsev, A., Tran, H., Popvic, A., Kovacic, F., Brown, G., Flick, R., Hajighasemi, M., Egorova, O., Somody, J. C., Tchigvintsev, D., Khusnutdinova, A., Chernikova, T. N., Golyshina, O., Yakimov, M. M., Savchenko, A., Golyshin, P., Jaeger, K. E. & Yakunin, A. F., 1 Mar 2015, In: Applied Microbiology and Biotechnology. 99, 5, p. 2165-2178
    Research output: Contribution to journal › Article › peer-review

2014

  • PublishedPressure adaptation is linked to thermal adaptation in salt-saturated marine habitats
    Alcaide, M., Stogios, P. J., Lafraya, A., Tchigvintsev, A., Flick, R., Bargiela, R., Chernikova, T. N., Reva, O. N., Hai, T., Leggewie, C. C., Katzke, N., La Cono, V., Matesanz, R., Jebbar, M., Jaeger, K., Yakimov, M. M., Yakunin, A. F., Golyshin, P. N., Golyshina, O. V. & Savchenko, A. & 1 others, Ferrer, M., 17 Dec 2014, In: Environmental Microbiology. 17, 2, p. 332-345
    Research output: Contribution to journal › Article › peer-review
  • PublishedThe CRISPR-associated Cas4 protein Pcal_0546 from Pyrobaculum calidifontis contains a [2Fe-2S] cluster: crystal structure and nuclease activity
    Lemak, S., Nocek, B., Beloglazova, N., Skarina, T., Flick, R., Brown, G., Joachimiak, A., Savchenko, A. & Yakunin, A. F., 29 Sept 2014, In: Nucleic Acids Research. 42, 17, p. 11144-11155
    Research output: Contribution to journal › Article › peer-review

2013

  • PublishedGenome sequence and functional genomic analysis of the oil-degrading bacterium Oleispira antarctica
    Golyshina, O., Hai, T., Kube, M., Chernikova, T. N., Al-Ramahi, Y., Beloqui, A., Lopez-Cortez, N., Guazzaroni, M. E., Heipieper, H. J., Klages, S., Kotsyurbenko, O. R., Langer, I., Nechitaylo, T. Y., Lünsdorf, H., Fernández, M., Juárez, S., Ciordia, S., Singer, A., Kagan, O. & Egorova, O. & 18 others, Petit, P. A., Stogios, P., Kim, Y., Tchigvintsev, A., Flick, R., Denaro, R., Genovese, M., Albar, J. P., Reva, O. N., Martínez-Gomariz, M., Tran, H., Ferrer, M., Savchenko, A., Yakunin, A. F., Yakimov, M. M., Golyshina, O. V., Reinhardt, R. & Golyshin, P. N., 23 Jul 2013, In: Nature Communications. 4, p. 2156
    Research output: Contribution to journal › Article › peer-review

2012

  • PublishedStructure and activity of the cold-active and anion-activated carboxyl esterase OLEI01171 from the oil-degrading marine bacterium Oleispira antarctica
    Lemak, S., Tchigvintsev, A., Petit, P., Flick, R., Singer, A. U., Brown, G., Evdokimova, E., Egorova, O., Gonzalez, C. F., Chernikova, T. N., Yakimov, M. M., Kube, M., Reinhardt, R., Golyshin, P. N., Savchenko, A. & Yakunin, A. F., 15 Jul 2012, In: Biochemical Journal. 445, 2, p. 193-203
    Research output: Contribution to journal › Article › peer-review

Activities

2022

  • BU-IIA Funded Project: Exploring technology transfer options for microbial bioaugmentation of anaerobic waste biomass conversion to biogas

    The overarching aim of this application is to build on our current work on the EU SYNBIOGAS project which is developing engineered microbial communities to enhance waste biomass conversion to biomass. This proposal, which will fund additional plant-scale bioaugmentation of anaerobic digestion processes and techno-economic assessment of the bioprocess, enables us to increase our research activity at TRL6 and build a roadmap for technology adoption by our industrial partners. The project will facilitate applications for follow-on-funding, generate REF-relevant impact and provide possibilities for commercialisation. The project aligns directly with the University’s Strategy 2030 and the RWIF strategic priorities. 

    Funding awarded through the Bangor University Innovation and Impact Award (Research Wales Innovation Funding). Value = £42,055

    1 Apr 2022 – 31 Mar 2023

    Activity: Other (Contributor)

Projects

  • 21ENGBIO: Polyphosphate-based synthetic pathway (PSP) for bioconversion of isopentenols to isoprenoid precursors using recombinant cell lysates

    31/01/2022 – 09/08/2024 (Finished)

  • Discovery of novel thermostable hydrolases from archaea of the Kuril-Kamchatka region

    01/12/2020 – 19/08/2023 (Finished)

Home

About Us

Academic Schools and Colleges

School of Environmental and Natural Sciences

  • Staff
    • Professor Alexander Yakunin
Home

Follow Us

  • Twitter
  • Facebook
  • Instagram
  • Youtube
  • LinkedIn

Bangor University

Bangor, Gwynedd, LL57 2DG, UK

+44 (0)1248 351151

Contact Us

Visit Us

Maps & Directions

Policy

  • Legal Compliance
  • Modern Slavery Act 2015 Statement
  • Accessibility Statement
  • Privacy and Cookies
  • Welsh Language Policy
Map

Bangor University is a Registered Charity: No. 1141565

© 2020 Bangor University