Module MSE-4084:
Genomics & Infectious Disease
Genomics & Infectious Disease 2023-24
MSE-4084
2023-24
North Wales Medical School
Module - Semester 1 & 2
15 credits
Module Organiser:
David Pryce
Overview
- Infection as a cause of national and global morbidity and mortality_x000D_
- Transmission of human infections: person to person, food and waterborne, sexually transmitted, vector-borne_x000D_
- Prokaryotes, their genome, replication and population genetics_x000D_
- Genomic characterisation of viruses: DNA and RNA genomes, single-stranded, double stranded, segmented_x000D_
- Genomic comparisons of microbial strains in the context of outbreaks and transmissions in hospitals and the community_x000D_
- Anti-infective drug action_x000D_
- Mutation rate & drug resistance_x000D_
- Genomic evidence of individual susceptibility to specific infection_x000D_
- Role of genomics in: infectious disease diagnosis, prognosis, drug selection, resistance, monitoring, epidemic control, drug research.x000D x000D
Learning Outcomes
- Critique the molecular basis of organism drug resistance in some infections and how this directs drug research
- Demonstrate an in-depth knowledge of and explain the differences between prokaryote and eukaryote genomes_x000D_
- Discuss and appraise how the genome sequence of pathogens can be used to track cross infection and outbreaks of infections among the population
- Evaluate how sequencing of the genome of infective organisms can be used in infectious disease for assessing: diagnosis, sub-classification & strain identity, pathogenicity, drug resistance and drug selection; and for epidemic control.
- Review the emerging action of drugs in controlling infection e.g. HIV, TB
Assessment type
Crynodol
Description
Essay or coursework
Weighting
65%
Assessment type
Crynodol
Description
Report
Weighting
35%