Adv. topics in Inorg. Chem.
Run by School of Natural Sciences
10 Credits or 5 ECTS Credits
Organiser: Dr Lorrie Murphy
Overall aims and purpose
This module aims to provide an in depth study of selected important topics in advanced inorganic chemistry; bio-inorganic chemistry of metalloproteins (structure, function and advanced characterisation) and an appreciation of the diverse chemistry associated with the so-called 'electron deficient' cluster compounds.
(12 lectures) - Bio-inorganic Chemistry - This series of lectures will focus on the chemistry of metal ions in biological systems, particularly on the design of enzyme active sites with regard to their main biological roles. Bulk metals (Na, K, Ca and Mg) will be introduced but the main focus will be on important trace metals (e.g. Fe, Zn and Cu), and key ligand types (O, N and S-based ligands). Characterisation techniques which are applicable to enzyme active sites and special topics (e.g. metal uptake/transport) will also be studied.
(12 lectures) - Structure and shapes of boron hydrides: historical introduction, definitions and terminology, shapes of binary boron hydrides, nomenclature. Bonding in boranes: valence bond approach to B2H6, Linear Combination of Atomic Orbital (LCAO) approach, styx numbers and bonding in boranes. Predicting the topology of boron hydrides: molecular orbital theory for B6H62-, electron counting rules (Wade's rules) as derived from MO theory. Chemistry of typical boron hydrides: preparation and interconversion of boron hydrides, reactions of diborane(6), reactions of decaborane(14). Carboranes: electron counting rules for predicting structures, synthesis of carboranes, mechanisms of interconversions of 1,2-C2B10H12 to 1,7- and 1,12- isomers, metal complexes. 'Naked' main group clusters: polyatomic Zintl anions of Sn, Pb, Bi; application of Wade's rules; polyatomic Bi cluster cations. The isolobal analogy: bonding in octahedral metal complexes; metal-ligand fragments of an octahedron in relation to main group fragments. Metal complexes of boron hydrides: MLx fragments for use in Wade's rules; preparative reactions to form readily available boron hydride anions; metal complexes of anions. High nuclearity carbonyl clusters: total electron counts (TEC) for large metal clusters; capped structures; explanations of the structures observed for large Os, Rh, and Ni/Pt carbonyl clusters.
Course Team: Dr Lorrie Murphy, Dr M Beckett
RESOURCE IMPLICATIONS ESSENTIAL READING 1. Inorganic Chemistry, C E Housecroft, A G Sharp (Prentice Hall) Most Recent edition of this as it is regularly updated RECOMMENDED READING 1. Advanced Inorganic Chemistry 6th Ed., F. Albert Cotton, Geoffrey Wilkinson, Carlos A. Murillo and Manfred Bochmann (Wiley), 1999. 2. Teaching General Chemistry – a Materials Science Companion”, A.B. Ellis et al., (American Chemical Society, Washington, 1993) 3. Cluster Molecules of the p-block elements, C E Housecroft (Oxford Chemistry Primer 1994) 4. Non-metal Rings, Cages and Clusters, Woollins (Wiley 1987) 5. Oxford Chemistry Primer (46) Inorganic Chemistry in Biology: P C Wilkins, R E Wilkins, (OUP) reprint 2005
a) Knowledge and understanding of course content is basic b) Problems of a routine nature are generally adequately solved; c) Transferable skills are at a basic level.
For students entering year 2 (level 5) after September 1st 2013 or MSc/MRes students, the threshold criteria are set as follows:
Knowledge base covers all essential aspects of subject matter dealt with in the assignment; conceptual understanding is acceptable.
Problems of a familiar and unfamiliar nature are solved and solutions are acceptable. Performance in transferable skills is sound.
a) Knowledge and understanding of course content is good b) Problems of a familiar and unfamiliar nature are solved in a logical manner; solutions are generally correct and acceptable. c) Performance in transferable skills is sound and shows no significant deficiencies.
For students entering year 2 (level 5) after September 1st 2013 or MSc/MRes students, the threshold criteria are set as follows: Knowledge base covers all essential aspects of subject matter dealt with in the assignment and shows good evidence of enquiry beyond this. Conceptual understanding is good. Problems of a familiar and unfamiliar nature are solved in a logical manner; solutions are generally correct and acceptable. Performance in transferable skills is sound and shows no significant deficiencies.
a) Knowledge and understanding of course content is outstanding. a) Problems of a familiar and unfamiliar nature are solved with efficiency and accuracy; problem-solving procedures are adjusted to the nature of the problem. b) Experimental work is exemplary and shows a through analysis and appraisal of experimental results, with appropriate suggestions for improvement. c) Performance in transferable skills is generally very good.
For students entering year 2 (level 5) after September 1st 2013 or MSc/MRes students, the threshold criteria are set as follows: Knowledge base is extensive and extends well beyond the work covered in the assignment; conceptual understanding is outstanding. Problems of a familiar and unfamiliar nature are solved with efficiency and accuracy; problem-solving procedures are adjusted to the nature of the problem. Performance in transferable skills is generally very good.
On successful completion of the module, the student will be able to: Explain, in brief, fundamental relevant chemical, structural and physical properties of specific metalloproteins
On successful completion of the module, the student will be able to: Suggest and rationalise appropriate advanced methods of elucidating the chemical, structural and physical properties of an unknown metalloprotein(s)
On completion of the module, students should be able to demonstrate: factual knowledge associated with the synthesis, structures and reactivities of boron hydride, heteroborane, naked main group and transition metal cluster compounds.
On completion of the module, students should be able to demonstrate: an understanding of Wade's rules and their use in predicting cluster geometries.
On completion of the module, students should be able to demonstrate: an understanding of the isolobal analogy as a bridge between organic and inorganic fragments
Teaching and Learning Strategy
The module has 24 one hour lectures scheduled at 2 lectures per week. Contact time 24h, private study 76h.
- Literacy - Proficiency in reading and writing through a variety of media
- Numeracy - Proficiency in using numbers at appropriate levels of accuracy
- Critical analysis & Problem Solving - Able to deconstruct and analyse problems or complex situations. To find solutions to problems through analyses and exploration of all possibilities using appropriate methods, rescources and creativity.
Subject specific skills
- CC4 The ability to recognise and analyse problems and plan strategies for their solution
- CC5 Skills in the generation, evaluation, interpretation and synthesis of chemical information and data
- PS2 Skills in the employment of common conventions and standards in scientific writing, data presentation, and referencing literature
- PS3 Problem-solving skills, relating to qualitative and quantitative information
- PS6 Information technology skills which support the location, management, processing, analysis and presentation of scientific information
- SK2 Demonstrate a systematic understanding of fundamental physicochemical principles with the ability to apply that knowledge to the solution of theoretical and practical problems
- SK3 Gain knowledge of a range of inorganic and organic materials
- PS16 The ability to work in multi-disciplinary and multi-skilled teams
- SK9 Read and engage with scientific literature
- CC1 the ability to demonstrate knowledge and understanding of essential facts,concepts,principles and theories relating to theSubject areasCovered in theirProgramme
- CC2 the ability to applysuch knowledge and understanding to thesolution of qualitative and quantitativeProblems that are mostly of a familiar nature
Courses including this module
Compulsory in courses:
- F104: MChem Chemistry year 4 (MCHEM/CH)
- F106: MChem Chemistry with International Experience year 5 (MCHEM/CHIE)
- F101: MChem Chemistry with Industrial Experience year 5 (MCHEM/CIND)
Optional in courses:
- F1AJ: MSc Analytical Chemistry year 1 (MSC/ANCHEM)