2022

• E-pub ahead of printIdentification of the mechanism of action of CYT-0851, an inhibitor of monocarboxylate transporter (MCT) mediated lactate transport
  Bradley, B., Belmonte, M. A., Kansara, S., Blank, J. L., Cryan, L., Reilly, N. M., Murali, V., Miller, D. H. & Secrist, J. P., 28 Oct 2022, (E-pub ahead of print) In: European Journal of Cancer. 174, 1, p. S24-S25
  Research output: Contribution to journal › Article › peer-review

2017

• PublishedNedd8-activating enzyme inhibitor pevonedistat synergizes with cisplatin and carboplatin through interference with nucleotide excision repair and interstrand cross-link repair mechanisms in non-small cell lung cancer
  Liu, X., Bouck, D., Garcia, K., Blank, J., Bernard, H., Berger, A., Kuranda, M., Koenig, E. & Lightcap, E., 1 Jul 2017, In: Cancer Research. 77, 13
  Research output: Contribution to journal › Article › peer-review

2015

• PublishedEFFECTIVE USE OF BORTEZOMIB AND PLASMA FILTRATION IN A CRITICALLY ILL PATIENT WITH LUPUS NEPHRITIS AND MYOCARDITIS: A CASE REPORT AND DYNAMICS OF (IMMUNO) PROTEASOME INHIBITION
  Tsang-A-Sjoe, M. W. P., de Groot, K. A., Niewerth, D., Cloos, J., Blank, J. L., Zweegman, S., Jansen, G., Voskuyl, A. E. & van der Heijden, J. W., 1 Mar 2015, In: Annals of the Rheumatic Diseases. 74, 1, p. A88
  Research output: Contribution to journal › Article › peer-review
• PublishedPharmacodynamic monitoring of (immuno)proteasome inhibition during bortezomib treatment of a critically ill patient with lupus nephritis and myocarditis
  de Groot, K. A., Tsang A Sjoe, M., Niewerth, D., Cloos, J., Blank, J. L., Niessen, H. W. M., Zweegman, S., Voskuyl, A. E., Jansen, G. & van der Heijden, J. W., 18 Dec 2015, In: Lupus science & medicine. 2, 1, e000121.
  Research output: Contribution to journal › Article › peer-review

2014

• PublishedInterferon-γ-induced upregulation of immunoproteasome subunit assembly overcomes bortezomib resistance in human hematological cell lines
  Niewerth, D., Kaspers, G. J. L., Assaraf, Y. G., van Meerloo, J., Kirk, C. J., Anderl, J., Blank, J. L., van de Ven, P. M., Zweegman, S., Jansen, G. & Cloos, J., 13 Jan 2014, In: Journal of hematology & oncology. 7, 7.
  Research output: Contribution to journal › Article › peer-review
• PublishedNedd8-activating enzyme inhibitor MLN4924 provides synergy with mitomycin C through interactions with ATR, BRCA1/BRCA2, and chromatin dynamics pathways
  Garcia, K., Blank, J. L., Bouck, D. C., Liu, X. J., Sappal, D. S., Hather, G., Cosmopoulos, K., Thomas, M. P., Kuranda, M., Pickard, M. D., Liu, R., Bandi, S., Smith, P. G. & Lightcap, E. S., Jun 2014, In: Mol. Cancer Ther.. 13, 6, p. 1625-35 11 p.
  Research output: Contribution to journal › Article › peer-review

2013

• PublishedActivation of p53 by the NEDD8 activating enzyme inhibitor MLN4924 is independent of Cdt1 and involves the cullin-RING ligase CRL4-DTL
  Blank, J. L., Liu, X. J., Bernard, H., Liao, H., Cosmopoulos, K. & Lightcap, E. S., 1 Nov 2013, In: Mol. Cancer Ther.. 12, 11, S
  Research output: Contribution to journal › Article
• PublishedNovel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924
  Blank, J. L., Liu, X. J., Cosmopoulos, K., Bouck, D. C., Garcia, K., Bernard, H., Tayber, O., Hather, G., Liu, R., Narayanan, U., Milhollen, M. A. & Lightcap, E. S., 2 Jan 2013, In: Cancer Research. 73, 1, p. 225-34 10 p.
  Research output: Contribution to journal › Article › peer-review

2012

• PublishedGenome-wide screen for modulators of cell death induced by the NEDD8-activating enzyme inhibitor MLN4924
  Cosmopoulos, K., Blank, J., Liu, X., Bouck, D., Garcia, K., Liao, H., Bernard, H., Tayber, O., Hather, G., Liu, R. & Lightcap, E., 15 Apr 2012, In: Cancer Research. 72, 8
  Research output: Contribution to journal › Article
• PublishedOptimization of a series of dipeptides with a P3 β-neopentyl asparagine residue as non-covalent inhibitors of the chymotrypsin-like activity of human 20S proteasome
  Blackburn, C., Barrett, C., Blank, J. L., Bruzzese, F. J., Bump, N., Dick, L. R., Fleming, P., Garcia, K., Hales, P., Jones, M., Liu, J. X., Nagayoshi, M., Sappal, D. S., Sintchak, M. D., Tsu, C., Xia, C., Zhou, X. & Gigstad, K. M., 1 Jun 2012, In: RSC Medicinal Chemistry. 3, 6, p. 710-719 10 p.
  Research output: Contribution to journal › Article › peer-review

2011

• PublishedQuantitative proteomic analysis of cellular protein modulation upon inhibition of the NEDD8-activating enzyme by MLN4924
  Liao, H., Liu, X. J., Blank, J. L., Bouck, D. C., Bernard, H., Garcia, K. & Lightcap, E. S., Nov 2011, In: Molecular and Cellular Proteomics. 10, 11, M111.009183.
  Research output: Contribution to journal › Article › peer-review

2010

• PublishedCharacterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit
  Blackburn, C., Gigstad, K. M., Hales, P., Garcia, K., Jones, M., Bruzzese, F. J., Barrett, C., Liu, J. X., Soucy, T. A., Sappal, D. S., Bump, N., Olhava, E. J., Fleming, P., Dick, L. R., Tsu, C., Sintchak, M. D. & Blank, J. L., 15 Sept 2010, In: Biochemical Journal. 430, 3, p. 461-76 16 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedEvaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer
  Kupperman, E., Lee, E. C., Cao, Y., Bannerman, B., Fitzgerald, M., Berger, A., Yu, J., Yang, Y., Hales, P., Bruzzese, F., Liu, J., Blank, J., Garcia, K., Tsu, C., Dick, L., Fleming, P., Yu, L., Manfredi, M., Rolfe, M. & Bolen, J., 1 Mar 2010, In: Cancer Research. 70, 5, p. 1970-80 11 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedGenome-wide siRNA screen for modulators of cell death induced by proteasome inhibitor bortezomib
  Chen, S., Blank, J. L., Peters, T., Liu, X. J., Rappoli, D. M., Pickard, M. D., Menon, S., Yu, J., Driscoll, D. L., Lingaraj, T., Burkhardt, A. L., Chen, W., Garcia, K., Sappal, D. S., Gray, J., Hales, P., Leroy, P. J., Ringeling, J., Rabino, C. & Spelman, J. J. & 2 others, Morgenstern, J. P. & Lightcap, E. S., 1 Jun 2010, In: Cancer Research. 70, 11, p. 4318-26 9 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedOptimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome
  Blackburn, C., Barrett, C., Blank, J. L., Bruzzese, F. J., Bump, N., Dick, L. R., Fleming, P., Garcia, K., Hales, P., Hu, Z., Jones, M., Liu, J. X., Sappal, D. S., Sintchak, M. D., Tsu, C. & Gigstad, K. M., 15 Nov 2010, In: Bioorganic & medicinal chemistry letters. 20, 22, p. 6581-6586 6 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedSeries of non-covalent inhibitors of the human 20S Proteasome derived from N-b-neopentyl asparagine with unprecedented potency and selectivity
  Blackburn, C., Barrett, C., Bump, N., Bruzzese, F., Dick, L., Fleming, P., Garcia, K., Gigstad, K., Hales, P., Herman, L., Jones, M., Liu, J., Sappal, D., Sintchak, M., Tsu, C. & Blank, J., 22 Aug 2010, In: Abstracts of papers - American Chemical Society. 240
  Research output: Contribution to journal › Article

2009

• PublishedA genome-wide siRNA screen for modulators of cell death induced by the proteasome inhibitor bortezomib
  Chen, S., Blank, J. L., Peters, T., Liu, J., Rappoli, D. M., Pickard, M. D., Menon, S., Yu, J., Driscoll, D. L., Lingaraj, T., Burkhardt, A. L., Chen, W., Sappal, D. S., Gray, J., Garcia, K., Hales, P., Leroy, P. J., Ringeling, J., Rabino, C. & Spelman, J. J. & 2 others, Morgenstern, J. P. & Lightcap, E. S., 1 Dec 2009, In: Mol. Cancer Ther.. 8, 12, S
  Research output: Contribution to journal › Article
• PublishedIn-Vitro and in-Vivo Evaluation of the Orally Active Proteasome Inhibitor MLN9708 in Hematological Models of Human Cancer
  Kupperman, E., Lee, E., Cao, Y., Bannerman, B., Fitzgerald, M., Berger, A. J., Yu, J., Zhang, J., Hales, P., Bruzzese, F., Liu, J., Blank, J., Garcia, K., Tsu, C., Dick, L., Fleming, P., Yu, L., Manfredi, M. G., Rolfe, M. & Bolen, J., 20 Nov 2009, In: BLOOD. 114, 22, p. 1061 1 p.
  Research output: Contribution to journal › Article
• PublishedPreclinical evalution of the orally active proteasome inhibitor MLN9708 in preclinical models of human cancer
  Kupperman, E., Berger, A., Yu, L., Tsu, C., Frank, B., Liu, J., Blank, J., Larry, D., Paul, F., Yueying, C., Bannerman, B., Fitzgerald, M., Zhang, J., Yu, J., Hales, P., Manfredi, M., Bolen, J. & Rolfe, M., 1 May 2009, In: Cancer Research. 69, 9
  Research output: Contribution to journal › Article

2007

• PublishedThe JAMM motif of human deubiquitinase Poh1 is essential for cell viability
  Gallery, M., Blank, J. L., Lin, Y., Gutierrez, J. A., Pulido, J. C., Rappoli, D., Badola, S., Rolfe, M. & Macbeth, K. J., Jan 2007, In: Mol. Cancer Ther.. 6, 1, p. 262-8 7 p.
  Research output: Contribution to journal › Article › peer-review

2006

• PublishedComparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib
  Williamson, M. J., Blank, J. L., Bruzzese, F. J., Cao, Y., Daniels, J. S., Dick, L. R., Labutti, J., Mazzola, A. M., Patil, A. D., Reimer, C. L., Solomon, M. S., Stirling, M., Tian, Y., Tsu, C. A., Weatherhead, G. S., Zhang, J. X. & Rolfe, M., Dec 2006, In: Mol. Cancer Ther.. 5, 12, p. 3052-61 10 p.
  Research output: Contribution to journal › Article › peer-review

2004

• PublishedNF-kappaB promotes survival during mitotic cell cycle arrest
  Mistry, P., Deacon, K., Mistry, S., Blank, J. & Patel, R., 9 Jan 2004, In: Journal of Biological Chemistry. 279, 2, p. 1482-90 9 p.
  Research output: Contribution to journal › Article › peer-review

2003

• PublishedActivation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) by group I metabotropic glutamate receptors
  Thandi, S., Blank, J. & Challiss, R., 1 Jun 2003, In: British Journal of Pharmacology. 139, S
  Research output: Contribution to journal › Article
• PublishedEvidence for cross-talk between M2 and M3 muscarinic acetylcholine receptors in the regulation of second messenger and extracellular signal-regulated kinase signalling pathways in Chinese hamster ovary cells
  Hornigold, D. C., Mistry, R., Raymond, P. D., Blank, J. L. & Challiss, R. A. J., Apr 2003, In: British Journal of Pharmacology. 138, 7, p. 1340-50 11 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedMEKK3 interacts with the PA28 gamma regulatory subunit of the proteasome
  Hagemann, C., Patel, R. & Blank, J. L., 1 Jul 2003, In: Biochemical Journal. 373, Pt 1, p. 71-79 9 p.
  Research output: Contribution to journal › Article › peer-review
• Publishedp38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest
  Deacon, K., Mistry, P., Chernoff, J., Blank, J. L. & Patel, R., May 2003, In: Molecular Biology of the Cell. 14, 5, p. 2071-87 17 p.
  Research output: Contribution to journal › Article › peer-review

2002

• PublishedA novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK
  Enserink, J. M., Christensen, A. E., de Rooij, J., van Triest, M., Schwede, F., Genieser, H. G., Døskeland, S. O., Blank, J. L. & Bos, J. L., Nov 2002, In: Nature cell biology. 4, 11, p. 901-6 6 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedGroup-I metabotropic glutamate receptors, mGlu1a and mGlu5a, couple to extracellular signal-regulated kinase (ERK) activation via distinct, but overlapping, signalling pathways
  Thandi, S., Blank, J. L. & Challiss, R. A. J., Dec 2002, In: Journal of Neurochemistry. 83, 5, p. 1139-53 15 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedGrowth inhibition by the muscarinic M(3) acetylcholine receptor: evidence for p21(Cip1/Waf1) involvement in G(1) arrest
  Burdon, D., Patel, R., Challiss, R. A. J. & Blank, J. L., 15 Oct 2002, In: Biochemical Journal. 367, Pt 2, p. 549-59 11 p.
  Research output: Contribution to journal › Article › peer-review

2001

• PublishedThe ups and downs of MEK kinase interactions
  Hagemann, C. & Blank, J. L., Dec 2001, In: Cellular Signalling. 13, 12, p. 863-75 13 p.
  Research output: Contribution to journal › Review article › peer-review

1999

• PublishedMEK kinase 3 directly activates MKK6 and MKK7, specific activators of the p38 and c-Jun NH2-terminal kinases
  Deacon, K. & Blank, J. L., 4 Jun 1999, In: Journal of Biological Chemistry. 274, 23, p. 16604-10 7 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedRegulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G-protein-linked muscarinic acetylcholine receptors
  Wylie, P. G., Challiss, R. A. & Blank, J. L., 15 Mar 1999, In: Biochemical Journal. 338 ( Pt 3), Pt 3, p. 619-28 10 p.
  Research output: Contribution to journal › Article › peer-review

1998

• PublishedComparative study of extracellular signal regulated protein kinase (ERK) and c-Jun NH2-terminal kinase (JNK) in CHO cells expressing M2- and M3-muscarinic receptors
  Wylie, P., Challiss, R. & Blank, J., 1 Dec 1998, In: British Journal of Pharmacology. 125, S
  Research output: Contribution to journal › Article
• PublishedHuman adenosine A1 receptor and P2Y2-purinoceptor-mediated activation of the mitogen-activated protein kinase cascade in transfected CHO cells
  Dickenson, J. M., Blank, J. L. & Hill, S. J., Aug 1998, In: British Journal of Pharmacology. 124, 7, p. 1491-9 9 p.
  Research output: Contribution to journal › Article › peer-review
• Publishedp21WAF1 is dynamically associated with JNK in human T-lymphocytes during cell cycle progression
  Patel, R., Bartosch, B. & Blank, J. L., Aug 1998, In: Journal of Cell Science. 111 ( Pt 15), p. 2247-55 9 p.
  Research output: Contribution to journal › Article › peer-review

1997

• PublishedCharacterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo
  Deacon, K. & Blank, J. L., 30 May 1997, In: Journal of Biological Chemistry. 272, 22, p. 14489-96 8 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedCloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway
  Gerwins, P., Blank, J. L. & Johnson, G. L., 28 Mar 1997, In: Journal of Biological Chemistry. 272, 13, p. 8288-95 8 p.
  Research output: Contribution to journal › Article › peer-review

1996

• PublishedMolecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase
  Blank, J. L., Gerwins, P., Elliott, E. M., Sather, S. & Johnson, G. L., 8 Mar 1996, In: Journal of Biological Chemistry. 271, 10, p. 5361-8 8 p.
  Research output: Contribution to journal › Article › peer-review

1995

• PublishedA region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits
  Chen, J., DeVivo, M., Dingus, J., Harry, A., Li, J., Sui, J., Carty, D. J., Blank, J. L., Exton, J. H., Stoffel, R. H., Inglese, J., Lefowitz, R. J., Logothetis, D. E., Hildebrandt, J. D. & Iyengar, R., 26 May 1995, In: Science. 268, 5214, p. 1166-1169 4 p.
  Research output: Contribution to journal › Article › peer-review

1994

• Published[14] Purification of activated and heterotrimeric forms of Gq proteins
  Blank, J. L. & Exton, J. H., 1994, In: Methods in Enzymology. 237, p. 174-81 8 p.
  Research output: Contribution to journal › Article › peer-review
• Published[19] Purification of 110 kDa phosphoinositide phospholipase C activated by G-protein βλ subunits
  Blank, J. L. & Exton, J. H., 1994, In: Methods in Enzymology. 238, p. 237-44 8 p.
  Research output: Contribution to journal › Article › peer-review

1993

• PublishedPurification of a 110-kDa phosphoinositide phospholipase C that is activated by G-protein beta gamma-subunits
  Blank, J. L., Shaw, K., Ross, A. H. & Exton, J. H., 25 Nov 1993, In: Journal of Biological Chemistry. 268, 33, p. 25184-25191 8 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedThe substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2
  Kwatra, M. M., Schwinn, D. A., Schreurs, J., Blank, J. L., Kim, C. M., Benovic, J. L., Krause, J. E., Caron, M. G. & Lefkowitz, R. J., 5 May 1993, In: Journal of Biological Chemistry. 268, 13, p. 9161-9164 4 p.
  Research output: Contribution to journal › Article › peer-review

1992

• PublishedActivation of cytosolic phosphoinositide phospholipase C by G-protein beta gamma subunits
  Blank, J. L., Brattain, K. A. & Exton, J. H., 15 Nov 1992, In: Journal of Biological Chemistry. 267, 32, p. 23069-23075 7 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedPhospholipase C-beta 1 is a GTPase-activating protein for Gq/11, its physiologic regulator
  Berstein, G., Blank, J., Jhon, D.-Y., Exton, J. H., Rhee, S. G. & Ross, E. M., 7 Aug 1992, In: Cell. 70, 3, p. 411-418 8 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedReconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1
  Berstein, G., Blank, J., Smrcka, A. V., Higashijima, T., Sternweis, P. C., Exton, J. H. & Ross, E. M., 25 Apr 1992, In: Journal of Biological Chemistry. 267, 12, p. 8081-8088 8 p.
  Research output: Contribution to journal › Article › peer-review

1991

• PublishedPurification and characterization of two G-proteins that activate the beta 1 isozyme of phosphoinositide-specific phospholipase C. Identification as members of the Gq class
  Blank, J., Ross, A. H. & Exton, J. H., 25 Sept 1991, In: Journal of Biological Chemistry. 266, 27, p. 18206-18216 11 p.
  Research output: Contribution to journal › Article › peer-review
• PublishedPURIFICATION FROM BOVINE LIVER PLASMA-MEMBRANES OF A G-PROTEIN WHICH ACTIVATES PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE-C
  Blank, J., Ross, A. & Exton, J., 11 Mar 1991, In: Faseb Journal. 5, 4, 1, p. A481
  Research output: Contribution to journal › Article
• PublishedPurification, properties, and phosphorylation by protein kinase C of two phosphoinositidase C isozymes from rat brain
  Blank, J. L., Foster, K. A. & Hawthorne, J. N., Jul 1991, In: Journal of Neurochemistry. 57, p. 15-21 7 p.
  Research output: Contribution to journal › Article › peer-review

1989

• PublishedPURIFICATION OF 2 PHOSPHOINOSITIDASE-C SPECIES FROM RAT-BRAIN
  Blank, J. & Hawthorne, J., 1 Feb 1989, In: Biochemical Society Transactions. 17, 1, p. 96-97 2 p.
  Research output: Contribution to journal › Article

• Bench fees to support the PhD funded under 2652821

  01/04/2025 – 15/04/2028 (Active)