Medical Sciences PhD/MPhil

Rhagarweiniad

Ffeithiau’r cwrs

  • Enw: Medical Sciences
  • Cymhwyster: PhD/MPhil

The School of Medical Sciences is always interested to hear from prospective PhD students who have, or are interested in applying for, funding.

Research Areas

Medical Sciences with specialisations in:

  • Rheumatic diseases
  • Inflammatory arthritis
  • Systemic lupus erythematosus
  • Behavioural neurology
  • Sensorimotor integration (on eye and limb movements)
  • Higher order sensory processing
  • Neuro-ophthalmology
  • Neuro-rehabilitation
  • Cardiac imaging using fMRI
  • Developing the use of Magnetic Resonance Imaging and Rendering
  • Effects of antipsychotic medication on neutrophil morphology and oxidative stress
  • Use of Quantitive Structural Activity Relations in cellular responses to antipsychotics
  • History of Medicine
  • Parkinson’s disease
  • Dementia and neurodegenerative diseases
  • Evidence based healthcare
  • Translation of research evidence to practice
  • Patient reported outcome following hip replacement surgery
  • Smell and taste pathophysiology, assessment and management
  • Assessment of Endoscopic Sinus Surgery
  • Transnasal fibreoptic flexible laryngo oesophagoscopy
  • Dizziness assessment and treatment
  • Catabolic effects of rheumatic diseases and effect on muscle mass and function
  • Autoimmune rheumatic diseases - prognosis, and assessment of treatment
  • Assessment of novel anti rheumatic treatment
  • Respiratory Medicine
  • Orthopaedic surgery
  • Sports and exercise medicine
  • Cardiac imaging and intervention
  • Cortical processes and cardiovascular
  • output
  • Cardiology and nuclear medicine
  • Clinical research into the assessment and development of new anti-cancer drugs
  • Assessment of the effects of chemotherapy
  • Intensive care medicine
  • Chronic disease patient care
  • Cardio-vascular risk factors in the severely mentally ill
  • Genetic predictors of antidepressant response
  • Mental illness in primary care patients
  • Diabetes and vascular disease

Basic Medical Research:

  • The genetics and molecular aeteology of cancer development / oncogenesis
  • Molecular mechanisms of disease related DNA repair pathways
  • The molecular basis of the cell division cycle (using human cells and model systems)
  • The molecular basis of cancer drug resistance
  • Molecular mechanisms of chromosomal translocations Molecular regulation of telomere biology
  • The role of human germ line genes in cancer development
  • The identification of new cancer-specific drug targets
  • The development of patient stratification strategies
  • Human stem cell biology
  • Human cancer stem cell biology
  • The molecular basis for human gut homeostasis
  • Molecular cancer immunology
  • Molecular autoimmunity 

A list of academic staff within the School of Medical Sciences can be found here, alternatively, contact medsciences@bangor.ac.uk with an outline of your research proposal, including actual or prospective funding, and an appropriate academic will be identified within the school.

 

Rhoddir cynnwys y cwrs ar gyfer arweiniad yn unig a gall newid.

Cyfleoedd Prosiect Ymchwil

Please note the research project opportunities detailed here are NOT funded by the University. Candidates must secure their own funding to meet the costs of PhD study.

If you are a European or International student this research programme is one of those which allows you to develop a research project proposal as an initial and integral part of a Combined English / Study Skills and Research Course at the University before starting the PhD/MPhil degree.

European and International candidates who have already reached the required level of English can apply for entry onto the project of their choice by presenting a relevant research proposal when applying for admission.

Alternatively you may also consider developing your own research proposal based on the research specialisms within the school.

The opportunities which are currently available are outlined below.

Cancer cell metabolism

Supervisor: Dr Rita Cha

T: +44 (0)1248 382865

E: r.cha@bangor ac.uk

A hallmark of cancer cells is uncontrolled growth, reproducing themselves over and over again within the body. We are investigating how cancer cells synthesize the building blocks necessary for generating a new cancer cell. Our long-term aim is to utilize the knowledge to find a way to stop cancer cell proliferation.

Please note this research project opportunity is NOT funded by the University. Candidates must secure their own funding to meet the costs of PhD study.

DNA repair in the model organism fission yeast

Supervisor: Dr Oliver Fleck

T: +44 (0)1248 388189

E: o.fleck@bangor.ac.uk

We are interested in genome stability, particularly nucleotide excision repair (NER), and mismatch repair (MMR), using the yeast Schizosaccharomyces pombe as model. Our PhD projects address the function of various MMR proteins in stability of repetitive DNA and of NER factors in repair of DNA adducts caused by chemotherapeutic agents. Both aspects are important for understanding of the mechanisms that can prevent certain types of cancer. In addition, the status of MMR and NER factors play a role as prognostic markers in cancer treatment.

Please note this research project opportunity is NOT funded by the University. Candidates must secure their own funding to meet the costs of PhD study.

Management of peripheral vascular disease / Management of diabetic foot disease / Management of Chronic wounds

Supervisor: Mr Dean Williams

T: +44 (0) 1248 388787 E: dean.williams@bangor.ac.uk

Atherosclerosis, lower limb ulceration and diabetic foot disease are major causes of limb loss and mortality. Although there is a positive correlation between a multidisciplinary approach and its impact on preventing loss of limb, what is less clear is the specific areas that have influenced those outcomes. These related areas of interest have potentially major clinical implications.

Please note this research project opportunity is NOT funded by the University. Candidates must secure their own funding to meet the costs of PhD study.

Molecular characterisation of the roles of autoantigens in Chronic Myeloid Leukemia

Supervisor: Dr David Pryce

T: +44 (0) 1248 382363
E: d.w.pryce@bangor.ac.uk

Chronic myeloid leukaemia (CML) is a form of blood cancer, which according to global trends, is steadily increasing in both incidence and prevalence. The discovery of the tyrosine kinase inhibitors (TKIs) - highly specific drugs that inhibit CML progression - has profoundly reduced CML-dependent mortality, from an annual rate of 10-20%, to approximately 2%. However, several issues still remain with the clinical effectiveness of TKI-based therapies; mainly they are rarely curative, patients may experience severe side effects, but treatment withdrawal almost invariably leads to disease relapse, and they require a considerable financial commitment for long-term treatment. Research into enhancing current and developing new alternative treatment options is therefore vital to sustain long-term CML treatment strategies. The PhD research projects in my laboratory are focusing on the characterising the roles of ‘autoantigens’ in CML development and progression, with the aim of developing new biomarkers and/or immuno therapeutic targets for CML diagnosis, prognosis and treatment.

Please note this research project opportunity is NOT funded by the University. Candidates must secure their own funding to meet the costs of PhD study.

Novel Regulators of Genome Stability

Supervisor: Dr Chris Staples

T: +44 (0) 1248 388776

E:c.staples@bangor.ac.uk

Genome maintenance and DNA repair are essential tumour-suppressing processes. Though many genome stability and DNA repair factors are extensively characterised, research in my lab has uncovered a number of completely unstudied proteins that prevent the accumulation of DNA damage in human cells including a novel DNA repair factor. My work focuses on figuring out what these factors are, what other proteins they bind to and how they protect the human genome. This in turn leads to more in-depth analysis of the roles of these proteins in cancer biology and studies determining their relevance to patient treatment regimes and ultimately survival.

Please note this research project opportunity is NOT funded by the University. Candidates must secure their own funding to meet the costs of PhD study.

Novel Roles of the DNA Damage Checkpoint Proteins in the Regulation of Glucose Metabolism and Diabetes

Supervisor: Dr Thomas Caspari

T: +44 (0) 1248 382526

E: t.caspari@bangor.ac.uk

Diabetes type II is a growing health concern in many countries. Exciting new work in my group revealed novel activities of the DNA damage checkpoint kinases ATR, ATM, Chk1 and Chk2 in the response to glucose limitation. This is also of high importance since these genome maintenance pathways act under low glucose concentrations in many cancers as malignant cells have up to 10-times less glucose available compared to healthy cells.

Please note this research project opportunity is NOT funded by the University. Candidates must secure their own funding to meet the costs of PhD study.

Stem cell/germ cell genes in cancer: clinical and functional roles

Supervisor: Dr. Ramsay McFarlane

T: +44 (0) 1248 382360

E: r.macfarlane@bangor.ac.uk

The process of oncogenesis is a complex multifaceted process. Cells undergo changes to their genomic structure and the transcriptional landscape. We have identified a group of genes are normally only active in human stem cells and germ cell, but become activated in cancers. We believe that they have excellent clinical potential as drug targets and for patient stratification. We are currently focussing on a few of these to determine their function in cancer cells, stem cells with a particular interest in how they might control of genome dynamics.  

Please note this research project opportunity is NOT funded by the University. Candidates must secure their own funding to meet the costs of PhD study.

Stem cells and differentiation in normal and cancer cells of the gut

Supervisor: Dr. Jane Wakeman

T: +44 (0)1248 382341

E: j.a.wakeman@bangor.ac.uk

Normal homeostasis of adult intestinal epithelium and repair following tissue damage is maintained by a balance of stem and differentiated cells. Mutations in stem cells of the gut are known to cause cancer, as such it is important that we know and understand the processes required to form and maintain stem cells and cancerous stem cells of the gut. We are investigating the role of a small population of gut cells, known as enteroendocrine cells, which are marked by the presence of a transcription factor known as Brachyury. These cells are secretory cells that are critical for integrating nutrient sensing with metabolic responses, but may also have additional functions in regulating intestinal stem cells or acting as reserve stem cells. Our work aims to understand the role of Brachyury in normal and cancer stem-like cells will serve as a platform for assessment of the molecular processes of intestinal homeostasis that underpins our understanding of human health, cancer and ageing.

Please note this research project opportunity is NOT funded by the University. Candidates must secure their own funding to meet the costs of PhD study.

The role of DNA repair mechanisms in resisting treatment with DNA damaging cancer drugs

Supervisor: Dr Edgar Hartsuiker

T: +44 (0) 1248 382350

E: e.hartsuiker@bangor.ac.uk

DNA damaging cancer drugs are a mainstay of cancer therapy, but it remains unknown which DNA repair pathways contribute to cellular resistance against these drugs. We have identified and are currently characterising various repair mechanisms which resist treatment with topoisomerase poisons (e.g. Irinotecan) and nucleoside analogues (e.g. Gemcitabine).

Please note this research project opportunity is NOT funded by the University. Candidates must secure their own funding to meet the costs of PhD study.

Gofynion Mynediad

Sut i Ymgeisio

Cyngor ar wneud cais

Mae ceisiadau ar gyfer graddau ymchwil yn wahanol i geisiadau am gyrsiau ôl-radd trwy ddysgu fel gradd Feistr. Er bod y ffurflen gais yr un ffurflen, mae’r ffordd y dylech fynd ati i wneud cais yn gwneud gwahaniaeth.

Gwneud cais ar gyfer PhD/Mphil wedi ei ariannu’n allanol neu gennych chi eich hun

Fel gydag ein holl gyrsiau, gallwch ariannu cwrs PhD/Mphil ym Mangor eich hun, neu efallai fod gennych gymorth ariannol allanol (er enghraifft gan eich cyflogwr neu gan y cynulliad), ac rydym yn croesawu pob cais am wneud hynny. Er hynny, yn hytrach na chwblhau ffurflen gais yn unig, gallwch gymryd camau syml er mwyn gwneud yn siŵr fod eich cais yn sefyll allan ac yn fwy tebygol o fod yn llwyddiannus.

Mae pob myfyriwr PhD/Mphil angen goruchwyliaeth gan o leiaf un aelod o staff y Brifysgol, ac os ydych yn ystyried PhD/Mphil mae gennych eisoes syniad o’r pwnc neu’r maes yr ydym am astudio ynddo. I wneud yn siŵr fod gan y Brifysgol arbenigedd yn y maes er mwyn darparu goruchwyliaeth, edrychwch yn gyntaf ar ein tudalennau staff.

Unwaith yr ydych wedi dod o hyd i aelod o staff sydd yn gwneud gwaith ymchwil yn y maes, gallwch gysylltu â hwy yn uniongyrchol gyda chrynodeb o’ch ymchwil sy’n amlinellu eich cais a gofynnwch a ydynt yn fodlon i oruchwylio eich project. Os yw’r aelod o staff academaidd yn dangos diddordeb, gallwch drafod ymhellach i ddatblygu cynnig ymchwil PhD/Mphil llawn.

Ar yr adeg yma, dylech wneud cais am y rhaglen PhD/Mphil gan ddefnyddio'r ffurflen sydd ar gael yma. Dylech gwblhau’r ffurflen yn llawn gan gynnwys cyfeirnodau academaidd, eich cais ymchwil ac enw’r aelod o staff academaidd sydd am eich goruchwylio.

Ymgeisio am ysgoloriaethau PhD a hysbysebir gan Brifysgol Bangor

Eich cynnig ymchwil

Mae cynnig ymchwil da yn hanfodol os ydych yn ymgeisio am PhD neu MPhil. Dylai’r cynnig gynnwys:

(i) Trosolwg - rhowch fraslun o'r maes pwnc yr ydych am ymchwilio iddo, a rhoddwch wybodaeth am y dadleuon damcaniaethol, polisi ac empirig y byddwch yn ymdrin â hwy.
(ii) Cynllunio – rhaid i chi ddangos eich bod yn ymwybodol o amserlenni ymchwil, a bod gennych gynllun i reoli'ch gwaith. Rhaid i chi ddangos ei bod yn bosib cyflawni'r ymchwil yn yr amser sydd ar gael.
(iii) Cyfeiriadau llenyddol – rhaid i chi ddangos nad yw'ch maes ymchwil arfaethedig wedi'i astudio o'r blaen. Rhowch gyfeiriadau at erthyglau a thestunau llenyddol sy'n berthnasol i'ch maes astudio chi.
(iv) Methodoleg – rhaid i chi ddangos eich bod yn ymwybodol o'r offer methodolegol sydd ar gael, a nodi pa rai fyddai'n addas i'ch ymchwil chi.

Mwy o gyngor am baratoi eich cynnig ymchwil

Ymgeisio am ysgoloriaethau PhD a hysbysebir gan Brifysgol Bangor

Mae cyfleoedd i ennill ysgoloriaethau PhD wedi eu hariannu yn codi yn aml drwy gydol y flwyddyn, ac yn cael ei hysbysebu fel cyfleoedd penodol sydd yn gofyn i chi wneud cais ffurfiol. Mae’r broses gwneud cais ar gyfer ysgoloriaethau PhD wedi eu hariannu yn amrywio o ysgol i ysgol felly mae gofyn i chi edrych ar wefan yr ysgol academaidd briodol a dilyn y cyfarwyddiadau sydd ar gael yno. Os ydych yn ansicr o unrhyw ran o’r broses gneud cais, gallwch gysylltu â’r ysgol academaidd briodol yn uniongyrchol am gyngor neu gallwch e-bostio postgraduatestudy@bangor.ac.uk

Gallwch nawr wneud cais ar-lein ar gyfer holl raglenni ôl-raddedig trwy ddysgu a rhaglenni ymchwil ôl-raddedig y Brifysgol (gan eithrio TAR, Diploma mewn Therapi Galwedigaethol a DClinPsy).

Myfyrwyr Cartref/UE

Gwneud cais ar-lein

Gwneud cais ar-lein

Gyda phwy yr wyf angen cysylltu?

Am wybodaeth bellach neu gyngor am wneud cais, cysylltwch â'r Swyddfa Derbyniadau Ôl-raddedig

E-bost: postgraduate@bangor.ac.uk
Ffôn: (01248) 383717

Myfyrwyr Rhyngwladol

Pryd i wneud cais

Bydd y Brifysgol yn derbyn ceisiadau drwy gydol y flwyddyn ond byddwn yn gyffredinol yn eich annog i anfon eich cais cyn diwedd mis Mehefin. Mae hyn yn rhoi cyfle i chi wneud trefniadau ariannol a/neu lety ac i chi fedru cael gafael ar drawsgrifiadau a geirda os nad ydych wedi eu hanfon gyda’r cais gwreiddiol.

Mwy o Wybodaeth

Camau nesaf