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Dr Christopher Staples

Senior Lecturer in Biomedical Sciences (Cancer Biology)

c.staples@bangor.ac.uk

–

View Dr Christopher Staples’s profile on the Bangor Research Portal

Qualifications

  • PhD: Regulation of MAP kinase phosphatases
    University of Dundee, 2006–2010

Teaching and Supervision

Teaching Credits

MSE-3016 Pathophysiology (10 credits) - Module Organiser

MSE-2025 Molecular Biology and Biochemistry (10 credits) 

MSE-3013 Third Year Research Project 

MSE-4025 Dissertation

Teaching and Supervision Roles

Undergraduate project/dissertation supervision. Supervision of PhD, MSc and MRes students.

Other roles

College representative on Research Concordat Committee

External and internal viva voce examiner

Teaching and Scholarship Awards

PGCertHE Stage 1 (2017)

PGCertHE Stage 2 (2018)

Fellow of the Higher Education Academy (HEA)

Research Interests

Work in the Staples laboratory focuses largely on the characterisation of novel genome stability factors. Genome instability and DNA damage are central pathogenic mechanisms involved in cancer predisposition, premature ageing and neurodegeneration. Indeed, some cancer therapies target cancer-specific defects in DNA repair or replication fork protection mechanisms, and as such a complete understanding of such mechanisms is a major asset in the fight against cancer.

We have identified several novel DNA repair and replication fork protection factors, and our aim is to gain mechanistic insight into the function of these largely unstudied proteins with the ultimate goal of using this knowledge to design novel cancer therapies and/or predict therapeutic response.

Postgraduate Project Opportunities

Investigation of novel replication fork protection factors Investigation of small-molecule inhibitors of the DNA damage response

Publications

2023

  • PublishedRuthenium(II) Polypyridyl Complexes as FRET Donors: Structure- and Sequence-Selective DNA-Binding and Anticancer Properties
    Elgar, C. E., Yusoh, N. A., Tiley, P. R., Kolozsvári, N., Bennett, L., Gamble, A., Péan, E. V., Davies, M. L., Staples, C., Ahmad, H. & Gill, M. R., 18 Jan 2023, In: Journal of the American Chemical Society. 145, 2, p. 1236-1246 11 p.
    Research output: Contribution to journal › Article › peer-review

2020

  • PublishedMRNIP is a replication fork protection factor
    Bennett, L., Wilkie, A., Antonopoulou, E., Ceppi, I., Sanchez, A., Vernon, E., Gamble, A., Myers, K. N., Collis, S. J., Cejka, P. & Staples, C., 10 Jul 2020, In: Science Advances. 6, 28, 10 p., eaba5974.
    Research output: Contribution to journal › Article › peer-review

2017

  • PublishedApproaches for Identifying Novel Targets in Precision Medicine: Lessons from DNA Repair
    Williams, D. T. & Staples, C., 25 Aug 2017, Personalised Medicine. El-Khamisy, S. (ed.). Springer, Vol. 1007. p. 1-16 16 p. (Advances in Experimental Medicine and Biology).
    Research output: Chapter in Book/Report/Conference proceeding › Chapter

2016

  • PublishedHuman CDK18 promotes replication stress signaling and genome stability
    Barone, G., Staples, C. J., Ganesh, A., Patterson, K. W., Bryne, D. P., Myers, K. N., Patil, A. A., Eyers, C. E., Maslen, S., Skehel, J. M., Eyers, P. A. & Collis, S. J., 14 Oct 2016, In: Nucleic Acids Research. 44, 18, p. 8772-8785 14 p.
    Research output: Contribution to journal › Article › peer-review
  • PublishedMRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response
    Staples, C. J., Barone, G., Myers, K. N., Ganesh, A., Gibbs-Seymour, I., Patil, A. A., Beveridge, R. D., Daye, C., Beniston, R., Maslen, S., Ahel, I., Skehel, J. M. & Collis, S. J., 6 Sep 2016, In: Cell. 16, 10, p. 2565-75 11 p.
    Research output: Contribution to journal › Article › peer-review
  • PublishedThe bornavirus-derived human protein EBLN1 promotes efficient cell cycle transit, microtubule organisation and genome stability
    Myers, K. N., Barone, G., Ganesh, A., Staples, C. J., Howard, A. E., Beveridge, R. D., Maslen, S., Skehel, J. M. & Collis, S. J., 14 Oct 2016, In: Scientific Reports. 6, p. 35548
    Research output: Contribution to journal › Article › peer-review

2014

  • PublishedCcdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability
    Staples, C. J., Myers, K. N., Beveridge, R. D., Patil, A. A., Howard, A. E., Barone, G., Lee, A. J., Swanton, C., Howell, M., Maslen, S., Skehel, J. M., Boutlon, S. J. & Collis, S. J., 1 Jul 2014, In: Journal of Cell Science. 127, p. 2910-2919
    Research output: Contribution to journal › Article › peer-review
  • PublishedThe leukemia-associated Rho guanine nucleotide exchange factor LARG is required for efficient replication stress signaling
    Beveridge, R. D., Staples, C. J., Patil, A. A., Myers, K. N., Maslen, S., Skehel, J. M., Boulton, S. J. & Collis, S. J., 29 Oct 2014, In: Cell Cycle. 13, 21, p. 3450-3459
    Research output: Contribution to journal › Article › peer-review

2011

  • PublishedPhosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways
    Dickinson, R. J., Delavaine, L., Cejudo-Marín, R., Stewart, G., Staples, C. J., Didmon, M. P., Trinidad, A. G., Alonso, A., Pulido, R. & Keyse, S. M., 4 Nov 2011, In: Journal of Biological Chemistry. 286, 44, p. 38018-26 9 p.
    Research output: Contribution to journal › Article › peer-review

2010

  • PublishedCross-talk between the p38alpha and JNK MAPK pathways mediated by MAP kinase phosphatase-1 determines cellular sensitivity to UV radiation
    Staples, C. J., Owens, D. M., Maier, J. V., Cato, A. C. B. & Keyse, S. M., 20 Aug 2010, In: Journal of Biological Chemistry. 285, 34, p. 25928-40 13 p.
    Research output: Contribution to journal › Article › peer-review

2009

  • PublishedRegulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK
    Kucharska, A., Rushworth, L. K., Staples, C., Morrice, N. A. & Keyse, S. M., Dec 2009, In: Cellular Signalling. 21, 12, p. 1794-805 12 p.
    Research output: Contribution to journal › Article › peer-review

2008

  • PublishedNegative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter
    Ekerot, M., Stavridis, M. P., Delavaine, L., Mitchell, M. P., Staples, C., Owens, D. M., Keenan, I. D., Dickinson, R. J., Storey, K. G. & Keyse, S. M., 1 Jun 2008, In: Biochemical Journal. 412, 2, p. 287-98 12 p.
    Research output: Contribution to journal › Article › peer-review

2007

  • PublishedBiophysical properties of salmonid alphaviruses: influence of temperature and pH on virus survival
    Graham, D. A., Staples, C., Wilson, C. J., Jewhurst, H., Cherry, K., Gordon, A. & Rowley, H. M., Sep 2007, In: Journal of Fish Biology. 30, 9, p. 533-43 11 p.
    Research output: Contribution to journal › Article › peer-review

Activities

2021

  • BBSRC reviewer

    20 Jun 2021

    Activity: Types of External academic engagement - Contribution to the work of national or international committees and working groups (Contributor)
  • The Role of HERC2 in Ciliogenesis

    Invited talk at the 26th UK Cilia Network Symposium

    17 May 2021

    Activity: Oral presentation (Speaker)
  • NWCR Scientific Committee Membership

    Member of scientific panel

    9 May 2021 →

    Activity: Types of External academic engagement - Contribution to the work of national or international committees and working groups (Contributor)
  • Peer reviewer for the Humane Research Trust

    9 May 2021

    Activity: Types of External academic engagement - Contribution to the work of national or international committees and working groups (Contributor)

2020

  • DNA Repair (Journal)

    Peer reviewer

    7 Nov 2020

    Activity: Publication peer-review (Editorial board member)
  • Peer-reviewer for UKRI Future Leaders Fellowships

    Peer-reviewer for UKRI Future Leaders Fellowships

    25 Oct 2020

    Activity: Types of External academic engagement - Contribution to the work of national or international committees and working groups (Contributor)
  • Molecular Oncology (Journal)

    Peer review

    11 Sep 2020

    Activity: Publication peer-review (Editorial board member)
  • BBSRC Peer Review

    Reviewed a BBSRC Responsive Mode Application

    31 Aug 2020

    Activity: Types of External academic engagement - Contribution to the work of national or international committees and working groups (Contributor)
  • Internal Examiner for PhD Viva

    21 Apr 2020

    Activity: Examination (Examiner)
  • Chair for PhD Viva

    2 Apr 2020

    Activity: Examination (Examiner)
  • Peer review

    Provided peer review for a BBSRC project grant application

    4 Mar 2020

    Activity: Types of External academic engagement - Contribution to the work of national or international committees and working groups (Contributor)
  • PLoS Biology (Journal)

    Acted as peer reviewer

    7 Jan 2020

    Activity: Publication peer-review (Editorial board member)

2019

  • External examiner for PhD candidate in Lancaster

    Supervised by Nikki Copeland

    13 Jun 2019

    Activity: Examination (Examiner)
  • Examined Prof Ciaran Morrisons PhD student (Galway)

    External examiner

    4 Jun 2019

    Activity: Examination (Examiner)
  • MRNIP is a novel replication fork protection factor

    15 min talk at international conference

    2019

    Activity: Oral presentation (Speaker)

2018

  • Novel players in replication fork protection

    Invited speaker to research seminar series

    18 Mar 2018

    Activity: Oral presentation (Speaker)
  • External examiner for MRes viva

    29 Jan 2018

    Activity: Examination (Examiner)

2017

  • Internal Examiner for PhD viva

    9 Nov 2017

    Activity: Examination (Examiner)
  • The role of MRNIP in DNA repair

    Invited speaker to research seminar series

    11 May 2017

    Activity: Oral presentation (Speaker)

Projects

  • A novel role for the innate immune sensor IFI16 in the cancer cell response to chemotherapy

    01/01/2024 – 15/01/2026 (Not started)

  • Regulation of chemosensitivity by the novel daughter strand gap suppressor MRNIP

    01/12/2023 – 15/12/2026 (Not started)

  • Daughter strand gaps as crucial determinants of therapeutic response

    01/10/2022 – 31/10/2025 (Active)

  • KESS II MRes with NWCR - BUK2E089

    01/10/2022 – 31/10/2023 (Active)

  • KESS II MRes with BEE Robotics BUK2E081

    01/07/2022 – 31/10/2023 (Active)

  • HEFCW HEIR COVID extension to UKRI FLF MRC bid (F008177, R49R01, MR/S034579/1)

    01/05/2021 – 31/08/2021 (Finished)

  • KESS II MRes with North West Cancer Research BUK2225

    01/01/2021 – 30/11/2022 (Finished)

  • KESS II East Phd with North West Cancer Research BUK2E019

    01/02/2020 – 31/07/2023 (Active)

  • The role of MRNIP in replication fork stabilisation and DSB repair

    01/12/2019 – 31/12/2023 (Active)

  • Potential roles of MRNIP and IFI16 in linking oncogene-induced replication

    01/07/2019 – 21/09/2022 (Finished)

  • Replication fork reversal and stability (UNS87415 Mr Anuj Narwal)

    01/06/2019 – 01/08/2019 (Finished)

  • Investigation of novel regulators of genome stability

    01/01/2019 – 02/05/2023 (Finished)

  • Autophagy dependent survival following Mec1(ATM/ATR) inactivation

    01/05/2018 – 31/07/2023 (Active)

  • Role of RadIP, a novel DNA repair factor in the DNA damage response to chemotherapy.

    01/11/2016 – 31/08/2020 (Finished)

  • Targeting CtIP to sensitise cancer cells to DNA-damaging agents

    01/10/2016 – 31/07/2018 (Finished)

  • Therapeutically relevant novel links between DNA damage and ciliogenesis

    01/10/2016 – 04/02/2023 (Finished)

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