Cancer is a disease that has touched us all, and although we now know a lot about how cancers develop and grow, we still have a lot to learn. A major factor in cancer development and in treatment resistance is the presence of genome instability. This essentially involves frequent alterations to the genomic DNA of the cell, including changes to the letters of the genetic code as well as more obvious changes such as chromosome deletions, or even movement of large DNA fragments from one chromosome to another. Work in UKRI Future Leader Fellow Dr Chris Staples’ laboratory housed at the North West Cancer Research Institute (in the School of Medical Sciences at Bangor University) focuses on how cells normally prevent such genome instability from occurring.
Publication date: 26 July 2020