• PhD: Development and application of linked pharmacometric-pharmacoeconomic analyses in clinical drug development
  2019
• BSc: Mathematical Physics
  University of Edinburgh, 2009

Dan is a Research Fellow in Pharmacoeconomics at the Centre for Health Economics and Medicines Evaluation. He joined in 2015 to undertake a PhD on the development and application of linked pharmacometric and pharmacoeconomic modelling to support decision making in clinical drug development. This was a three-year PhD studentship funded by the Medical Research Council’s Network of Hubs for Trials Methodology Research. Prior to this Dan spent over 4 years as a Research Associate in Cost Effectiveness Modelling at the University of Sheffield. His undergraduate degree was in Mathematical Physics.

Dan’s research interests are in the methods of economic evaluation, in particular; linked pharmacometric and pharmacoeconomic modelling and value of information methods to support drug development decisions. Since completion of a PhD, his research activities have included an economic evaluation alongside the NERVES (NErve Root block VErsus Surgery) clinical trial, and an analysis of the spatial and temporal variation in prescribing of certain high-cost medication in the Betsi Cadwaladr University Health Board.

2021

• Wedi ei Dderbyn / Yn y wasgA Randomised Controlled Trial of Surgical Microdiscectomy versus Trans-foraminal Epidural Steroid Injection for sciatica of up to 1 year; the NERVES trial
  Wilby, M. J., Best, A., Wood, E., Burnside, G., Bedson, E., Short, H., Wheatley, D., Hill-McManus, D., Sharma, M., Clark, S., Baranidharan, G., Price, C., Mannion, R., Hutchinson, P. J., Hughes, D., Marson, A. G. & Williamson, P., 26 Ion 2021, (Wedi ei Dderbyn / Yn y wasg) Yn : The Lancet Rheumatology.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl
• CyhoeddwydCombining model-based clinical trial simulation, pharmacoeconomics and value of information to optimize trial design
  Hill-McManus, D. & Hughes, D., Ion 2021, Yn : CPT: Pharmacometrics & Systems Pharmacology . 10, 1, t. 75-83 9 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl

2020

• E-gyhoeddi cyn argraffuLinked Pharmacometric-Pharmacoeconomic Modeling and Simulation in Clinical Drug Development
  Hill-McManus, D., Marshall, S., Liu, J., Willke, R. & Hughes, D., 16 Medi 2020, Yn : Clinical Pharmacology and Therapeutics.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl

2019

• CyhoeddwydIntegration of Pharmacometrics and Pharmacoeconomics to Quantify the Value of Improved Forgiveness to Nonadherence: A Case Study of Novel Xanthine Oxidase Inhibitors for Gout
  Hill McManus, D., Marshall, S., Soto, E. & Hughes, D., Medi 2019, Yn : Clinical Pharmacology and Therapeutics. 106, 3, t. 652-660
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl
• CyhoeddwydModeling the Potential Impact of Changing Access Rates to Specialist Treatment for Alcohol Dependence for Local Authorities in England: The Specialist Treatment for Alcohol Model (STreAM)
  Brennan, A., Hill-McManus, D., Stone, T., Buykx, P., Ally, A., Pryce, R. E., Alston, R., Jones, A., Cairns, D., Millar, T., Donmall, M., Phillips, T., Meier, P. & Drummond, C., 28 Ion 2019, Yn : Journal of Studies on Alcohol and Drugs, Supplement. Sup 18, s18, t. 96-109 14 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl

2018

• CyhoeddwydImpact of non-adherence and flare resolution on the cost effectiveness of treatments for gout: Application of a linked pharmacometric/pharmacoeconomic model
  Hill-McManus, D., Marshall, S., Soto, E., Lane, S. & Hughes, D., Rhag 2018, Yn : Value in Health. 21, 12, t. 1373-1381
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl
• CyhoeddwydImpact of non-adherence on the safety and efficacy of uric acid lowering therapies in the treatment of gout
  Hill McManus, D., Soto, E., Marshall, S., Lane, S. & Hughes, D., Ion 2018, Yn : British Journal of Clinical Pharmacology. 84, 1, t. 142-152
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl

2017

• CyhoeddwydIssues Related to the Frequency of Exploratory Analyses by Evidence Review Groups in the NICE Single Technology Appraisal Process
  Kaltenthaler, E., Carroll, C., Hill-McManus, D., Scope, A., Holmes, M., Rice, S., Rose, M., Tappenden, P. & Woolacott, N., Meh 2017, Yn : PharmacoEconomics - Open. 1, 2, t. 99-108 10 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl
• CyhoeddwydThe Type and Impact of Evidence Review Group Exploratory Analyses in the NICE Single Technology Appraisal Process
  Carroll, C., Kaltenthaler, E., Hill-McManus, D., Scope, A., Holmes, M., Rice, S., Rose, M., Tappenden, P. & Woolacott, N., Meh 2017, Yn : Value in Health. 20, 6, t. 785-791 7 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl

2016

• CyhoeddwydThe use of exploratory analyses within the national institute for health and care excellence single technology appraisal process: An evaluation and qualitative analysis
  Kaltenthaler, E., Carroll, C., Hill-McManus, D., Scope, A., Holmes, M., Rice, S., Rose, M., Tappenden, P. & Woolacott, N., Ebr 2016, Yn : Health Technology Assessment. 20, 26, t. 1-48 48 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl

2014

• CyhoeddwydAlcohol tax pass-through across the product and price range: Do retailers treat cheap alcohol differently?
  Ally, A. K., Meng, Y., Chakraborty, R., Dobson, P. W., Seaton, J. S., Holmes, J., Angus, C., Guo, Y., Hill-Mcmanus, D., Brennan, A. & Meier, P. S., Rhag 2014, Yn : Addiction. 109, 12, t. 1994-2002 9 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl
• CyhoeddwydEffects of minimum unit pricing for alcohol on different income and socioeconomic groups: A modelling study
  Holmes, J., Meng, Y., Meier, P. S., Brennan, A., Angus, C., Campbell-Burton, A., Guo, Y., Hill-McManus, D. & Purshouse, R. C., 10 Chwef 2014, Yn : The Lancet. 383, 9929, t. 1655-1664 10 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl
• CyhoeddwydEstimation of own and cross price elasticities of alcohol demand in the UK-A pseudo-panel approach using the Living Costs and Food Survey 2001-2009
  Meng, Y., Brennan, A., Purshouse, R., Hill-McManus, D., Angus, C., Holmes, J. & Meier, P. S., Maw 2014, Yn : Journal of Health Economics. 34, 1, t. 96-103 8 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl
• CyhoeddwydEstimation of usual occasion-based individual drinking patterns using diary survey data
  Hill-McManus, D., Angus, C., Meng, Y., Holmes, J., Brennan, A. & Sylvia Meier, P., 1 Ion 2014, Yn : Drug and Alcohol Dependence. 134, 1, t. 136-143 8 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl
• CyhoeddwydPotential benefits of minimum unit pricing for alcohol versus a ban on below cost selling in England 2014: modelling study.
  Brennan, A., Meng, Y., Holmes, J., Hill-McManus, D. & Meier, P. S., 30 Medi 2014, Yn : BMJ. 349, g5452.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl
• CyhoeddwydTrend analysis and modelling of gender-specific age, period and birth cohort effects on alcohol abstention and consumption level for drinkers in Great Britain using the General Lifestyle Survey 1984-2009
  Meng, Y., Holmes, J., Hill-Mcmanus, D., Brennan, A. & Meier, P. S., Chwef 2014, Yn : Addiction. 109, 2, t. 206-215 10 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl

2013

• CyhoeddwydAdjusting for unrecorded consumption in survey and per capita sales data: Quantification of impact on gender- and age-specific alcohol-attributable fractions for oral and pharyngeal cancers in Great Britain
  Meier, P. S., Meng, Y., Holmes, J., Baumberg, B., Purshouse, R., Hill-McManus, D. & Brennan, A., Ebr 2013, Yn : Alcohol and Alcoholism. 48, 2, t. 241-249 9 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl
• CyhoeddwydMinimum unit pricing for alcohol: policy appraisal modelling of income and socioeconomic group-specific effects on consumption, spending, and health harms
  Holmes, J., Meng, Y., Meier, P. S., Brennan, A., Angus, C., Campbell-Burton, A., Guo, Y., Hill-McManus, D. & Purshouse, R. C., 29 Tach 2013, Yn : The Lancet. 382, t. S47-S47
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl

• Assessing the scale and variation of the impact of COVID-19 on primary care prescribing in Wales.

  05/08/2020 – 30/04/2021 (Wrthi'n gweithredu)