• PhD: Development and application of linked pharmacometric-pharmacoeconomic analyses in clinical drug development
  2019
• BSc: Mathematical Physics
  University of Edinburgh, 2009

Dan is a Research Fellow in Pharmacoeconomics at the Centre for Health Economics and Medicines Evaluation. He joined in 2015 to undertake a PhD on the development and application of linked pharmacometric and pharmacoeconomic modelling to support decision making in clinical drug development. This was a three-year PhD studentship funded by the Medical Research Council’s Network of Hubs for Trials Methodology Research. Prior to this Dan spent over 4 years as a Research Associate in Cost Effectiveness Modelling at the University of Sheffield. His undergraduate degree was in Mathematical Physics.

Dan’s research interests are in the methods of economic evaluation, in particular; linked pharmacometric and pharmacoeconomic modelling and value of information methods to support drug development decisions. Since completion of a PhD, his research activities have included an economic evaluation alongside the NERVES (NErve Root block VErsus Surgery) clinical trial, and an analysis of the spatial and temporal variation in prescribing of certain high-cost medication in the Betsi Cadwaladr University Health Board.

2021

• Accepted/In pressA Randomised Controlled Trial of Surgical Microdiscectomy versus Trans-foraminal Epidural Steroid Injection for sciatica of up to 1 year; the NERVES trial
  Wilby, M. J., Best, A., Wood, E., Burnside, G., Bedson, E., Short, H., Wheatley, D., Hill-McManus, D., Sharma, M., Clark, S., Baranidharan, G., Price, C., Mannion, R., Hutchinson, P. J., Hughes, D., Marson, A. G. & Williamson, P., 26 Jan 2021, (Accepted/In press) In : The Lancet Rheumatology.
  Research output: Contribution to journal › Article
• PublishedCombining model-based clinical trial simulation, pharmacoeconomics and value of information to optimize trial design
  Hill-McManus, D. & Hughes, D., Jan 2021, In : CPT: Pharmacometrics & Systems Pharmacology . 10, 1, p. 75-83 9 p.
  Research output: Contribution to journal › Article

2020

• E-pub ahead of printLinked Pharmacometric-Pharmacoeconomic Modeling and Simulation in Clinical Drug Development
  Hill-McManus, D., Marshall, S., Liu, J., Willke, R. & Hughes, D., 16 Sep 2020, In : Clinical Pharmacology and Therapeutics.
  Research output: Contribution to journal › Article

2019

• PublishedIntegration of Pharmacometrics and Pharmacoeconomics to Quantify the Value of Improved Forgiveness to Nonadherence: A Case Study of Novel Xanthine Oxidase Inhibitors for Gout
  Hill McManus, D., Marshall, S., Soto, E. & Hughes, D., Sep 2019, In : Clinical Pharmacology and Therapeutics. 106, 3, p. 652-660
  Research output: Contribution to journal › Article
• PublishedModeling the Potential Impact of Changing Access Rates to Specialist Treatment for Alcohol Dependence for Local Authorities in England: The Specialist Treatment for Alcohol Model (STreAM)
  Brennan, A., Hill-McManus, D., Stone, T., Buykx, P., Ally, A., Pryce, R. E., Alston, R., Jones, A., Cairns, D., Millar, T., Donmall, M., Phillips, T., Meier, P. & Drummond, C., 28 Jan 2019, In : Journal of Studies on Alcohol and Drugs. Sup 18, s18, p. 96-109 14 p.
  Research output: Contribution to journal › Article

2018

• PublishedImpact of non-adherence and flare resolution on the cost effectiveness of treatments for gout: Application of a linked pharmacometric/pharmacoeconomic model
  Hill-McManus, D., Marshall, S., Soto, E., Lane, S. & Hughes, D., Dec 2018, In : Value in Health. 21, 12, p. 1373-1381
  Research output: Contribution to journal › Article
• PublishedImpact of non-adherence on the safety and efficacy of uric acid lowering therapies in the treatment of gout
  Hill McManus, D., Soto, E., Marshall, S., Lane, S. & Hughes, D., Jan 2018, In : British Journal of Clinical Pharmacology. 84, 1, p. 142-152
  Research output: Contribution to journal › Article

2017

• PublishedIssues Related to the Frequency of Exploratory Analyses by Evidence Review Groups in the NICE Single Technology Appraisal Process
  Kaltenthaler, E., Carroll, C., Hill-McManus, D., Scope, A., Holmes, M., Rice, S., Rose, M., Tappenden, P. & Woolacott, N., Jun 2017, In : PharmacoEconomics - Open. 1, 2, p. 99-108 10 p.
  Research output: Contribution to journal › Article
• PublishedThe Type and Impact of Evidence Review Group Exploratory Analyses in the NICE Single Technology Appraisal Process
  Carroll, C., Kaltenthaler, E., Hill-McManus, D., Scope, A., Holmes, M., Rice, S., Rose, M., Tappenden, P. & Woolacott, N., Jun 2017, In : Value in Health. 20, 6, p. 785-791 7 p.
  Research output: Contribution to journal › Article

2016

• PublishedThe use of exploratory analyses within the national institute for health and care excellence single technology appraisal process: An evaluation and qualitative analysis
  Kaltenthaler, E., Carroll, C., Hill-McManus, D., Scope, A., Holmes, M., Rice, S., Rose, M., Tappenden, P. & Woolacott, N., Apr 2016, In : Health Technology Assessment. 20, 26, p. 1-48 48 p.
  Research output: Contribution to journal › Article

2014

• PublishedAlcohol tax pass-through across the product and price range: Do retailers treat cheap alcohol differently?
  Ally, A. K., Meng, Y., Chakraborty, R., Dobson, P. W., Seaton, J. S., Holmes, J., Angus, C., Guo, Y., Hill-Mcmanus, D., Brennan, A. & Meier, P. S., Dec 2014, In : Addiction. 109, 12, p. 1994-2002 9 p.
  Research output: Contribution to journal › Article
• PublishedEffects of minimum unit pricing for alcohol on different income and socioeconomic groups: A modelling study
  Holmes, J., Meng, Y., Meier, P. S., Brennan, A., Angus, C., Campbell-Burton, A., Guo, Y., Hill-McManus, D. & Purshouse, R. C., 10 Feb 2014, In : The Lancet. 383, 9929, p. 1655-1664 10 p.
  Research output: Contribution to journal › Article
• PublishedEstimation of own and cross price elasticities of alcohol demand in the UK-A pseudo-panel approach using the Living Costs and Food Survey 2001-2009
  Meng, Y., Brennan, A., Purshouse, R., Hill-McManus, D., Angus, C., Holmes, J. & Meier, P. S., Mar 2014, In : Journal of Health Economics. 34, 1, p. 96-103 8 p.
  Research output: Contribution to journal › Article
• PublishedEstimation of usual occasion-based individual drinking patterns using diary survey data
  Hill-McManus, D., Angus, C., Meng, Y., Holmes, J., Brennan, A. & Sylvia Meier, P., 1 Jan 2014, In : Drug and Alcohol Dependence. 134, 1, p. 136-143 8 p.
  Research output: Contribution to journal › Article
• PublishedPotential benefits of minimum unit pricing for alcohol versus a ban on below cost selling in England 2014: modelling study.
  Brennan, A., Meng, Y., Holmes, J., Hill-McManus, D. & Meier, P. S., 30 Sep 2014, In : BMJ. 349, g5452.
  Research output: Contribution to journal › Article
• PublishedTrend analysis and modelling of gender-specific age, period and birth cohort effects on alcohol abstention and consumption level for drinkers in Great Britain using the General Lifestyle Survey 1984-2009
  Meng, Y., Holmes, J., Hill-Mcmanus, D., Brennan, A. & Meier, P. S., Feb 2014, In : Addiction. 109, 2, p. 206-215 10 p.
  Research output: Contribution to journal › Article

2013

• PublishedAdjusting for unrecorded consumption in survey and per capita sales data: Quantification of impact on gender- and age-specific alcohol-attributable fractions for oral and pharyngeal cancers in Great Britain
  Meier, P. S., Meng, Y., Holmes, J., Baumberg, B., Purshouse, R., Hill-McManus, D. & Brennan, A., Apr 2013, In : Alcohol and Alcoholism. 48, 2, p. 241-249 9 p.
  Research output: Contribution to journal › Article
• PublishedMinimum unit pricing for alcohol: policy appraisal modelling of income and socioeconomic group-specific effects on consumption, spending, and health harms
  Holmes, J., Meng, Y., Meier, P. S., Brennan, A., Angus, C., Campbell-Burton, A., Guo, Y., Hill-McManus, D. & Purshouse, R. C., 29 Nov 2013, In : The Lancet. 382, p. S47-S47
  Research output: Contribution to journal › Article

• Assessing the scale and variation of the impact of COVID-19 on primary care prescribing in Wales.

  05/08/2020 – 30/04/2021 (Active)