Yr Athro Alexander Iakounine
Professor In Enzyme Discovery and Application
Gwybodaeth Cyswllt
Professor Alexander Yakunin (Iakounine)
Office: Thoday Building, room S25
Email: a.iakounine@bangor.ac.uk
Tel: 01248 388399
Research focus: enzyme discovery, enzymology, enzyme applications
Cymwysterau
- PhD: Microbiology
Winogradsky Institute of Microbiology, Moscow, 1987 - MSc: Molecular biology
Moscow State University, 1978
Cyfleoedd Project Ôl-radd
1. Novel extremophilic enzymes from environmental metagenomes and genomes;
2. Enzyme applications in bioremediation (plastics/microplastics recycling);
3. Enzyme applications in biocatalysis (biosynthesis of polymer precursors);
4. Novel CRISPR-associated enzymes.
Cyhoeddiadau
2023
- CyhoeddwydCRISPR-induced DNA reorganization for multiplexed nucleic acid detection
Karlikow, M., Amalfitano, E., Yang, X., Doucet, J., Chapman, A., Sadat-Moussavi, P., Homme, P., Sutyrina, P., Chang, W., Lemak, S., Yakunin, A., Dolezal, A. G., Kelley, S., Foster, L., Harpur, B. & Pardee, K., 17 Maw 2023, Yn: Nature Communications. 14, 1, 1505.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydHarnessing extremophilic carboxylesterases for applications in polyester depolymerisation and plastic waste recycling
Williams, G., Ma, H., Khusnutdinova, A., Yakunin, A. & Golyshin, P., Awst 2023, Yn: Essays in Biochemistry. 67, 4, t. 715-729 15 t., EBC20220255.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl adolygu › adolygiad gan gymheiriaid - E-gyhoeddi cyn argraffuStructural insights into hydrolytic defluorination of difluoroacetate by microbial fluoroacetate dehalogenases
Khusnutdinova, A. N., Batyrova, K., Brown, G., Fedorchuck, T., Chai, Y. S., Skarina, T., Flick, R., Petit, A-P., Savchenko, A., Stogios, P. & Yakunin, A., 17 Gorff 2023, (E-gyhoeddi cyn argraffu) Yn: Febs Journal.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydThermophilic Carboxylesterases from Hydrothermal Vents of the Volcanic Island of Ischia Active on Synthetic and Biobased Polymers and Mycotoxins
Distaso, M., Chernikova, T., Bargiela, R., Coscolín, C., Stogios, P. J., Gonzalez-Alfonso, J. L., Lemak, S., Khusnutdinova, A., Plou, F. J., Evdokimova, E., Savchenko, A., Lunev, E., Yakimov, M. M., Golyshina, O., Ferrer, M., Yakunin, A. & Golyshin, P., 28 Chwef 2023, Yn: Applied and Environmental Microbiology. 89, 2, t. e0170422 20 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2022
- CyhoeddwydMetabolite Damage and Damage-Control in a Minimal Genome
Haas, D., Thamm, A. M., Sun, J., Huang, L., Sun, L., Beaudoin, G. A. W., Wise, K. S., Lema-Ortiz, C., Bruner, S. D., Breuer, M., Luthey-Schutten, Z., Lin, J., Wilson, M. A., Brown, G., Yakunin, A., Kurilyak, I., Folz, J., Fiehn, O., Glass, J. I., Hanson, A. D., Henry, C. S. & de Crecy-Lagard, V., 30 Awst 2022, Yn: mBio. e0163022.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2021
- CyhoeddwydStructural and biochemical insights into CRISPR RNA processing by the Cas5c ribonuclease SMU1763 from Streptococcus mutans
Lemak, S., Serbanescu, M. A., Khusnutdinova, A. N., Ruszkowski, M., Beloglazova, N., Xu, X., Brown, G., Cui, H., Tan, K., Joachimiak, A., Cvitkovitch, D. G., Savchenko, A. & Yakunin, A., Tach 2021, Yn: Journal of Biological Chemistry. 297, 5, 101251.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2020
- CyhoeddwydOne-pot biocatalytic transformation of adipic acid to 6-aminocaproic acid and 1,6-hexamethylenediamine using carboxylic acid reductases and transaminases
Fedorchuk, T. P., Khusnutdinova, A. N., Evdokimova, E., Flick, R., Di Leo, R., Stogios, P. J., Savchenko, A. & Yakunin, A., 15 Ion 2020, Yn: Journal of the American Chemical Society. 142, 2, t. 1038-1048 11 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydProteome cold-shock response in the extremely acidophilic archaeon, Cuniculiplasma divulgatum
Bargiela, R., Lanthaler, K., Potter, C., Ferrer, M., Yakunin, A., Paizs, B., Golyshin, P. & Golyshina, O., 19 Mai 2020, Yn: Microorganisms . 8, 5
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2019
- CyhoeddwydPrenylated FMN: biosynthesis, purification, and Fdc1 activation
Khusnutdinova, A. N., Xiao, J., Wang, P-H., Batyrova, K., Flick, R., Edwards, E. & Yakunin, A., 2019, New Approaches for Flavin Catalysis. Palfey, B. A. (gol.). Elsevier, Cyfrol 620. t. 469-488 (Methods in Enzymology).
Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion Cynhadledd › Pennod › adolygiad gan gymheiriaid - CyhoeddwydSite-directed mutagenesis and stability of the carboxylic acid reductase MAB4714 from Mycobacterium abscessus
Fedorchuk, T. P., Khusnutdinova, A. N., Flick, R. & Yakunin, A., 10 Medi 2019, Yn: Journal of Biotechnology. 303, t. 72-79
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2018
- CyhoeddwydBiosynthesis and activity of prenylated FMN cofactors
Wang, P-H., Khusnutdinova, A. N., Luo, F., Xiao, J., Nemr, K., Flick, R., Brown, G., Mahadevan, R., Edwards, E. & Yakunin, A., 17 Mai 2018, Yn: Cell Chemical Biology. 25, 5, t. 560-570
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydDeterminants and prediction of esterase substrate promiscuity patterns
Martínez-Martínez, M., Coscolín, C., Santiago, G., Chow, J., Stogios, P. J., Bargiela, R., Gertler, C., Navarro-Fernández, J., Bollinger, A., Thies, S., Méndez-García, C., Popovic, A., Brown, G., Chernikova, T., García-Moyano, A., Bjerga, G. E. K., Perez-Garcia, P., Hai, T., del Pozo, M. V., Stokke, R., Steen, I. H., Cui, H., Xu, X., Nocek, B., Alcaide, M., Disasto, M., Mesa, V., Pelaez, A. I., Sanchez, J., Buchholz, P. C. F., Pleiss, J., Fernández-Guerra, A., Glockner, F. O., Golyshina, O., Yakimov, M. M., Savchenko, A., Jaeger, K-E., Yakunin, A. F., Streit, W. R., Golyshin, P., Guallar, V. & Ferrer, M., 2018, Yn: ACS Chemical Biology. 13, 1, t. 225-234
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydEngineering a short, aldolase based pathway for (R)-1,3-butanediol production in Escherichia coli
Nemr, K., Muller, J., Joo, J. C., Gawand, P., Cjoudhary, R., Mendonca, B., Lu, S., Yu, X., Yakunin, A. & Mahadevan, R., 1 Gorff 2018, Yn: Metabolic Engineering. 48, t. 13-24
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydHeavy metal removal by bioaccumulation using genetically engineered microorganisms
Diep, P., Mahadevan, R. & Yakunin, A., 29 Hyd 2018, Yn: Frontiers in Bioengineering and Biotechnology. 6, 157.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydRelationships between Substrate Promiscuity and Chiral Selectivity of Esterases from Phylogenetically and Environmentally Diverse Microorganisms
Coscolín, C., Martínez-Martínez, M., Chow, J., Bargiela, R., García-Moyano, A., Bjerga, G. E. K., Bollinger, A., Stokke, R., Steen, I. H., Golyshina, O., Yakimov, M. M., Jaeger, K-E., Yakunin, A. F., Streit, W. R., Golyshin, P. & Ferrer, M., 5 Ion 2018, Yn: Catalysts. 8, 1, 10.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydScreening and Characterization of Novel Polyesterases from Environmental Metagenomes with High Hydrolytic Activity against Synthetic Polyesters
Hajighasemi, M., Tchigvintsev, A., Nocek, B., Flick, R., Popovic, A., Hai, T., Khusnutdinova, A. N., Brown, G., Xu, X., Cui, H., Anstett, J., Chernikova, T., Bruls, T., Le Paslier, D., Yakimov, M. M., Joachimiak, A., Golyshina, O., Savchenko, A., Golyshin, P., Edwards, E. A. & Yakunin, A. F., 6 Tach 2018, Yn: Environmental Science and Technology. 52, 21, t. 12388-12401
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydStructural Insights into Substrate Selectivity and Activity of Bacterial Polyphosphate Kinases
Nocek, B. P., Khusnutdinova, A. N., Ruszkowski, M., Flick, R., Burda, M., Batyrova, K., Brown, G., Mucha, A., Joachimiak, A., Berlicki, L. & Yakunin, A. F., 2 Tach 2018, Yn: ACS Catalysis. 8, 11, t. 10746-10760
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2017
- CyhoeddwydActivity screening of environmental metagenomic libraries reveals novel carboxylesterase families
Popovic, A., Hai, T., Tchigvintsev, A., Hajighasemi, M., Nocek, B., Khusnutdinova, A. N., Brown, G., Glinos, J., Flick, R., Skarina, T., Chernikova, T., Yim, V., Bruls, T., Le Paslier, D., Yakimov, M. M., Joachimiak, A., Ferrer, M., Golyshina, O., Savchenko, A., Golyshin, P. & Yakunin, A. F., Maw 2017, Yn: Scientific Reports. 7, 44103, 44103.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydAlkene hydrogenation activity of enoate reductases for an environmentally benign biosynthesis of adipic acid
Joo, J. C., Khusnutdinova, A. N., Flick, R., Kim, T., Bornscheuer, U. T., Yakunin, A. F. & Mahadevan, R., 1 Chwef 2017, Yn: Chemical Science. 8, 2, t. 1406-1413
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydMetabolic and evolutionary patterns in the extremely acidophilic archaeon Ferroplasma acidiphilum YT
Golyshina, O., Hai, T., Reva, O. N., Lemak, S., Yakunin, A. F., Goesmann, A., Nechitaylo, T. Y., LaCono, V., Smedile, F., Slesarev, A., Rojo, D., Barbas, C., Ferrer, M., Yakimov, M. M. & Golyshin, P., 16 Meh 2017, Yn: Scientific Reports. 7, 3682.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydSAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia
Schneider, C., Oellerich, T., Baldauf, H-M., Schwarz, S-M., Thomas, D., Flick, R., Bohnenberger, H., Kaderali, L., Stegmann, L., Cremer, A., Martin, M., Lohmeyer, J., Michaelis, M., Hornung, V., Schliemann, C., Berdel, W. E., Hartmann, W., Wardelmann, E., Comoglio, F., Hansmann, M-L., Yakunin, A. F., Geisslinger, G., Stroebel, P., Ferreiros, N., Serve, H., Keppler, O. T. & Cinatl, J. J., Chwef 2017, Yn: Nature Medicine. 23, 2, t. 250-255
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2016
- CyhoeddwydA family of metal-dependent phosphatases implicated in metabolite damage-control
Huang, L., Khusnutdinova, A., Nocek, B., Brown, G., Xu, X., Cui, H., Petit, P., Flick, R., Zallot, R., Balmant, K., Ziemak, M. J., Shanklin, J., de Crecy-Lagard, V., Fiehn, O., Gregory, J. F. . III., Joachimiak, A., Savchenko, A., Yakunin, A. F. & Hanson, A. D., Awst 2016, Yn: Nature Chemical Biology. 12, 8, t. 621-627
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydBiochemical and structural insights into enzymatic depolymerization of polylactic acid and other polyesters by microbial carboxylesterases
Hajighasemi, M., Nocek, B. P., Tchigvintsev, A., Brown, G., Flick, R., Xu, X., Cui, H., Hai, T., Joachimiak, A., Golyshin, P., Savchenko, A., Edwards, E. A. & Yakunin, A. F., 18 Ebrill 2016, Yn: Biomacromolecules. 17, 6, t. 2027-2039
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2015
- CyhoeddwydCRISPR RNA binding and DNA target recognition by purified Cascade complexes from Escherichia coli
Beloglazova, N., Kuznedelov, K., Flick, R., Datsenko, K. A., Brown, G., Popovic, A., Lemak, S., Semenova, E., Severinov, K. & Yakunin, A. F., Ion 2015, Yn: Nucleic Acids Research. 43, 1, t. 530-543
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydDiversity of hydrolases from hydrothermal vent sediments of the Levante Bay, Vulcano Island (Aeolian archipelago) identified by activity-based metagenomics and biochemical characterization of new esterases and an arabinopyranosidase
Placido, A., Hai, T., Ferrer, M., Chernikova, T. N., Distaso, M. A., Armstrong, D., Yakunin, A. F., Toshchakov, S. V., Yakimov, M. M., Kublanov, I. V., Golyshina, O., Pesole, G., Ceci, L. R. & Golyshin, P., 1 Rhag 2015, Yn: Applied Microbiology and Biotechnology. 99, 23, t. 10031-10046
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydIdentification and characterization of carboxyl esterases of gill chamber-associated microbiota in the deep-sea shrimp Rimicaris exoculata using functional metagenomics
Alcaide, M., Tchigvinstsev, A., Martinez-Martinez, M., Popovic, A., Reva, O. N., Lafraya, A., Bargiela, R. N., Nechitaylo, T. Y., Matesanz, R., Cambon-Bonavita, M., Jebbar, M., Savchenko, A., Yakimov, M. M., Golyshina, O., Yakunin, A. F., Golyshin, P., Ferrer, M. & The MAMBA Consortium., N. V., 16 Ion 2015, Yn: Applied and Environmental Microbiology. 81, 6, t. 2125-2136
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydMetagenomics as a tool for enzyme discovery: hydrolytic enzymes from marine-related metagenomes
Popovic, A., Tchigvintsev, A., Tran, H., Chernikova, T. N., Golyshina, O. V., Yakimov, M. M., Golyshin, P. N. & Yakunin, A. F., 2015, Prokaryotic Systems Biology. Springer, t. 1-20 20 t.
Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion Cynhadledd › Pennod › adolygiad gan gymheiriaid - CyhoeddwydThe environment shapes microbial enzymes: five cold-active and salt-resistant carboxylesterases from marine metagenomes
Tchigvintsev, A., Tran, H., Popvic, A., Kovacic, F., Brown, G., Flick, R., Hajighasemi, M., Egorova, O., Somody, J. C., Tchigvintsev, D., Khusnutdinova, A., Chernikova, T. N., Golyshina, O., Yakimov, M. M., Savchenko, A., Golyshin, P., Jaeger, K. E. & Yakunin, A. F., 1 Maw 2015, Yn: Applied Microbiology and Biotechnology. 99, 5, t. 2165-2178
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2014
- CyhoeddwydPressure adaptation is linked to thermal adaptation in salt-saturated marine habitats
Alcaide, M., Stogios, P. J., Lafraya, A., Tchigvintsev, A., Flick, R., Bargiela, R., Chernikova, T. N., Reva, O. N., Hai, T., Leggewie, C. C., Katzke, N., La Cono, V., Matesanz, R., Jebbar, M., Jaeger, K., Yakimov, M. M., Yakunin, A. F., Golyshin, P. N., Golyshina, O. V., Savchenko, A. & Ferrer, M., 17 Rhag 2014, Yn: Environmental Microbiology. 17, 2, t. 332-345
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydThe CRISPR-associated Cas4 protein Pcal_0546 from Pyrobaculum calidifontis contains a [2Fe-2S] cluster: crystal structure and nuclease activity
Lemak, S., Nocek, B., Beloglazova, N., Skarina, T., Flick, R., Brown, G., Joachimiak, A., Savchenko, A. & Yakunin, A. F., 29 Medi 2014, Yn: Nucleic Acids Research. 42, 17, t. 11144-11155
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2013
- CyhoeddwydGenome sequence and functional genomic analysis of the oil-degrading bacterium Oleispira antarctica
Golyshina, O., Hai, T., Kube, M., Chernikova, T. N., Al-Ramahi, Y., Beloqui, A., Lopez-Cortez, N., Guazzaroni, M. E., Heipieper, H. J., Klages, S., Kotsyurbenko, O. R., Langer, I., Nechitaylo, T. Y., Lünsdorf, H., Fernández, M., Juárez, S., Ciordia, S., Singer, A., Kagan, O., Egorova, O., Petit, P. A., Stogios, P., Kim, Y., Tchigvintsev, A., Flick, R., Denaro, R., Genovese, M., Albar, J. P., Reva, O. N., Martínez-Gomariz, M., Tran, H., Ferrer, M., Savchenko, A., Yakunin, A. F., Yakimov, M. M., Golyshina, O. V., Reinhardt, R. & Golyshin, P. N., 23 Gorff 2013, Yn: Nature Communications. 4, t. 2156
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2012
- CyhoeddwydStructure and activity of the cold-active and anion-activated carboxyl esterase OLEI01171 from the oil-degrading marine bacterium Oleispira antarctica
Lemak, S., Tchigvintsev, A., Petit, P., Flick, R., Singer, A. U., Brown, G., Evdokimova, E., Egorova, O., Gonzalez, C. F., Chernikova, T. N., Yakimov, M. M., Kube, M., Reinhardt, R., Golyshin, P. N., Savchenko, A. & Yakunin, A. F., 15 Gorff 2012, Yn: Biochemical Journal. 445, 2, t. 193-203
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Projectau
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31/01/2022 – 28/11/2023 (Wrthi'n gweithredu)
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Discovery of novel thermostable hydrolases from archaea of the Kuril-Kamchatka region
01/12/2020 – 19/08/2023 (Wedi gorffen)