Rhagolwg
Evo-Devo@Bangor
My main research interest is in the way that genomic changes have influenced animal evolution and development. Current research projects focus on the GC-biased mutation in desert rodents, snake venom evolution, and the mechanisms by which the uterine environment can change gene expression in the embryo.
Gwybodaeth Cyswllt
Location: Room E1, 4th floor Brambell Building
Telephone: +44 (0)1248 383492
Personal webpage: www.johnmulley.com
Twitter: @JohnMulley
Cymwysterau
- DPhil: The Evolution of Vertebrate ParaHox Genes
Oxford University, 2007 - MSc: Biosystematics
Grand Challenges in Ecosystem and the Environment Initiative, Imperial College London, Silwood Park Campus, Ascot, Berkshire SL5 7PY, UK alexander.papadopulos@plants.ox.ac.uk., 2003 - BSc: Genetics
Department of Molecular and Clinical Pharmacology, University of Liverpool, 2002
Cyfleoedd Project Ôl-radd
Comparative genomics
I have a long-standing interest in vertebrate genome evolution, especially as it relates to gene and genome duplication, and/or the evolution of novelty. Whole genome duplications look likely to have played a significant role in the evolution of vertebrates, and particularly the development of vertebrate innovations, and gene duplication has been an important factor in the origin and diversification of snake venom.
Postgraduate opportunities in this area relate to the evolution of vertebrate homeobox genes; GC-biased mutation in desert rodents; and snake venom evolution, taking advantage of recent advances in long-read sequencing and techniques for the assembly of chromosome-scale genome assemblies such as Hi-C.
Evolution and Development (Evo-Devo)
Changes to embryonic development can have major effects on adult morphology, and the evolution of developmental processes has been a major driver of animal evolution.
Postgraduate opportunities in this area relate to my current research into vertebrate axial patterning, and particularly how the uterine environment might influence numbers and types of vertebrae in mouse models. These projects would require management of rodent breeding programs; collection of embryos; antibody-based hormones assays, and gene/protein expression studies. There is scope for expansion of this research into studies of human and non-human primate vertebral variation.
Snake venom evolution
The availability of whole genome sequences for multiple snake species is providing unprecedented insight into the processes underlying the origin and diversification of snake venom. Bangor University is one of the few Universities in the UK that maintains a collection of venomous snakes, and this invaluable resource facilitates research into the genetic factors responsible for inter- and intra-species variation in snake venom composition.
Postgraduate opportunities in this area relate to the determination of the gene and genome level mechanisms that drive variation in venom composition within and between species.
Cyhoeddiadau
2023
- CyhoeddwydA new chromosome-assigned Mongolian gerbil genome allows characterization of complete centromeres and a fully heterochromatic chromosome
Brekke, T. D., Papadopulos, A. S. T., Julia, E., Fornas, O., Fu, B., Yang, F., de la Fuente, R., Page, J., Baril, T., Hayward, A. & Mulley, J., Mai 2023, Yn: Molecular Biology and Evolution. 40, 5, msad115.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydIncubation temperature alters stripe formation and head colouration in American alligator hatchlings and is unaffected by estradiol-induced sex reversal
Rogerson, G., Bock, S., Loera, Y., Parrott, B. & Mulley, J., 31 Maw 2023, Yn: Journal of Experimental Biology. 226, 6, jeb245219.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydMate today, gone tomorrow: male-on-female cannibalism in Zamenis longissimus (Laurenti, 1768) in North Wales
Major, T., Bracegirdle, R., Gandini, A., Limia Russel, G., Pozzi, A., Morgan, R., Mulley, J. & Wüster, W., 17 Ion 2023, Yn: Herpetology Notes. 16, t. 51-54 4 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydShed skin as a source of DNA for genotyping-by-sequencing (GBS) in reptiles
Brekke, T. D., Shier, L., Hegarty, M. J. & Mulley, J., Medi 2023, Yn: Conservation Genetics Resources. 15, 3, t. 117-124 8 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydThe genome of Roselle's flesh fly Sarcophaga (Helicophagella) rosellei (Böttcher, 1912)
Falk, S. & Mulley, J., 31 Ion 2023, Yn: Wellcome Open Research . 8, 43, t. 43
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydThe genome sequence of
Philonthus cognatus (Stephens, 1832) (Coleoptera, Staphylinidae), a rove beetle.
Crowley, L. M., Telfer, M., Geiser, M. & Mulley, J., 13 Ebr 2023, Wellcome Open research, t. 169, (Wellcome open research).
Allbwn ymchwil: Papur gweithio › Rhagargraffiad - CyhoeddwydThe genome sequence of Ashworth’s Rustic, Xestia ashworthii (Doubleday, 1855)
Mulley, J., Lees, D., programme, W. S. I. T. O. L. & Consortium, D. T. O. L., 20 Rhag 2023, Yn: Wellcome Open Research . 8, 578
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydThe genome sequence of the Birch Marble, Apotomis betuletana (Haworth, 1811)
Mulley, J. & Boyes, D., 9 Chwef 2023, Yn: Wellcome Open Research . 8, t. 66
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydThe genome sequence of the Common Pug, Eupithecia vulgata (Haworth, 1809)
Boyes, D., Mulley, J. F. & Consortium, D. T. O. L., 23 Maw 2023, Yn: Wellcome Open Research. 8, 129, t. 129 1 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydThe genome sequence of the Dark Arches Apamea monoglypha (Hufnagel, 1766)
Boyes, D. & Mulley, J., 8 Chwef 2023, Yn: Wellcome Open Research . 8, 63.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydThe genome sequence of the Riband Wave, Idaea aversata (Linnaeus, 1758)
Boyes, D. & Mulley, J., 31 Ion 2023, Yn: Wellcome Open Research . 8, 45
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydThe genome sequence of the Six-striped Rustic, Xestia sexstrigata (Haworth, 1809)
Boyes, D., Mulley, J., collective, D. T. O. L. B. & programme, W. S. I. T. O. L., 8 Medi 2023, Yn: Wellcome Open Research . 8, 399
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydThe genome sequence of the Small Emerald, Hemistola chrysoprasaria (Esper, 1795)’
Boyes, D., Mulley, J., collective, D. T. O. L. B. & programme, W. S. I. T. O. L., 12 Hyd 2023, Yn: Wellcome Open Research . 8, 441
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydThe genome sequence of the Tawny Mining Bee, Andrena fulva (Müller, 1766)
Crowley, L. M., Mulley, J. F., Lab, U. O. O. A. W. W. G. A., collective, D. T. O. L. B., programme, W. S. I. T. O. L., collective, W. S. I. S. O. D. P., collective, T. O. L. C. I. & Consortium, D. T. O. L., 21 Meh 2023, Yn: Wellcome Open Research. 8, 258
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydThe genome sequence of the bluish flesh fly, Sarcophaga (Robineauella) caerulescens (Zetterstedt, 1838)
Falk, S. & Mulley, J., 12 Ion 2023, Yn: Wellcome Open Research . 8, 17
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydThe genome sequence of the lesser worm flesh fly,
Sarcophaga (
Sarcophaga)
subvicina (Baranov, 1937).
Falk, S. & Mulley, J., 8 Chwef 2023, Yn: Wellcome Open Research . 8, 65, t. 65
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydThe genome sequence of the short-fringed mining bee, Andrena dorsata (Kirby, 1802)
Falk, S., Mulley, J. F. & Consortium, D. T. O. L., 30 Awst 2023, Yn: Wellcome Open Research. 8, 373
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydThe genome sequence of the variegated flesh fly, Sarcophaga variegata (Scopoli, 1763)
Falk, S. & Mulley, J., 2 Meh 2023, Wellcome Open research, t. 234, (Wellcome open research).
Allbwn ymchwil: Papur gweithio › Rhagargraffiad
2022
- CyhoeddwydRegulation of posterior Hox genes by sex steroids explains vertebral variation in inbred mouse strains
Mulley, J., Ebr 2022, Yn: Journal of Anatomy. 240, 4, t. 735-745 11 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl adolygu › adolygiad gan gymheiriaid - CyhoeddwydThe genome sequence of the hawthorn shieldbug, Acanthosoma haemorrhoidale (Linnaeus, 1758)
Crowley, L. M. & Mulley, J., 5 Gorff 2022, Wellcome Open Research , 7, 178, t. 178 1 t.
Allbwn ymchwil: Cyfraniad at gyhoeddiad arbenigol › Erthygl
2020
- CyhoeddwydHow and why do primate vertebral columns vary? An investigation of intra- and interspecific variation and how it links to locomotor behaviour
Payne, M., Mulley, J. & Winder, I. C., Ebr 2020.
Allbwn ymchwil: Cyfraniad at gynhadledd › Crynodeb › adolygiad gan gymheiriaid - CyhoeddwydRunaway GC evolution in gerbil genomes
Parcana, R., Hargreaves, A. D., Mulley, J. & Holland, P. W. H., 1 Awst 2020, Yn: Molecular Biology and Evolution. 37, 8, t. 2197-2210 msaa072.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2019
- CyhoeddwydA high-density genetic map and molecular sex-typing assay for gerbils
Brekke, T., Mulley, J., Steele, K., Denver, M., Thom, A. & Supriya, S., Ebr 2019, Yn: Mammalian Genome. 30, 3-4, t. 63-70 8 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydAre locomotive styles in primates a driving force behind intra- and interspecies variation in the vertebral column?
Payne, M., Winder, I. C. & Mulley, J., 18 Rhag 2019.
Allbwn ymchwil: Cyfraniad at gynhadledd › Murlen › adolygiad gan gymheiriaid - CyhoeddwydGreater Loss of Female Embryos During Human Pregnancy: A Novel Mechanism
Mulley, J. F., Tach 2019, Yn: BioEssays : news and reviews in molecular, cellular and developmental biology. 41, 11
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydWhen one phenotype is not enough: divergent evolutionary trajectories govern venom variation in a widespread rattlesnake species
Zancolli, G., Calvete, J. J., Cardwell, M. D., Greene, H. W., Hayes, W. K., Hegarty, M. J., Herrmann, H.-W., Holycross, A. T., Lannutti, D. I., Mulley, J. F., Sanz, L., Travis, Z. D., Whorley, J. R., Wuster, C. E. & Wuster, W., 13 Maw 2019, Yn: Proceedings of the Royal Society B: Biological Sciences. 286, 1898, t. 20182735
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2018
- CyhoeddwydInbred or Outbred? Genetic Diversity in Laboratory Rodent Colonies
Brekke, T., Steele, K. & Mulley, J., 1 Chwef 2018, Yn: G3: Genes, Genomes, Genetics. 8, 2, t. 679-686
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydReport of the 2017 RSPCA/UFAW Rodent and Rabbit Welfare Group meeting
Hawkins, P., McBride, A., Paiba, G., Rose, R., Prescott, M. J., Mulley, J., Izzard, S., Ridley, D., Kappel, S., Melotti, L. & Hubrecht, R., Hyd 2018, Yn: Animal Technology and Welfare. 17, 2, t. 75-42
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2017
- CyhoeddwydGenome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster
Hargreaves, A. D., Zhou, L., Christensen, J., Marletaz, F., Liu, S., Li, F., Jansen, P. G., Spiga, E., Hansen, M. T., Pedersen, S. V. H., Biswas, S., Seriwaka, K., Fox, B. A., Taylor, W. R., Mulley, J., Zhang, G., Heller, R. S. & Holland, P. W. H., 18 Gorff 2017, Yn: Proceedings of the National Academy of Sciences of the United States of America: PNAS. 114, 29, t. 7677–7682
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2016
- CyhoeddwydThe spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons
Braasch, I., Gehrke, A. R., Smith, J. J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A. M., Campbell, M. S., Barrell, D., Martin, K. J., Mulley, J. F., Ravi, V., Lee, A. P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F. E., Sun, Y., Hertel, J., Beam, M. J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J. H., Litman, G. W., Litman, R. T., Mikami, M., Ota, T., Saha, N. R., Williams, L., Stadler, P. F., Wang, H., Taylor, J. S., Fontenot, Q., Ferrara, A., Searle, S. M., Aken, B., Yandell, M., Schneider, I., Yoder, J. A., Volff, J., Meyer, A., Amemiya, C. T., Venkatesh, B., Holland, P. W., Guiguen, Y., Bobe, J., Shubin, N. H., Di Palma, F., Alföldi, J., Lindblad-Toh, K. & Postlethwait, J. H., 7 Maw 2016, Yn: Nature Genetics.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2015
- CyhoeddwydA critique of the toxicoferan hypothesis
Hargreaves, A. D., Tucker, A. S., Mulley, J. F., Gopalakrishnakone, P. (Golygydd) & Malhotra, M. (Golygydd), 8 Awst 2015, Evolution of Venomous Animals and Their Toxins: Toxicology. Springer Netherlands, t. 1-15
Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion Cynhadledd › Pennod - CyhoeddwydAssessing the utility of the Oxford Nanopore MinION for snake venom gland cDNA sequencing
Hargreaves, A. D. & Mulley, J. F., 24 Tach 2015, Yn: PeerJ. t. e1441
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2014
- CyhoeddwydA plea for standardized nomenclature of snake venom toxins
Hargreaves, A. D. & Mulley, J. F., 27 Awst 2014, Yn: Toxicon. 90, t. 351-353
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydGenomic organisation of the seven ParaHox genes of coelacanths
Mulley, J. F. & Holland, P. W., 1 Medi 2014, Yn: Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 322, 6, t. 352-358
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydRestriction and Recruitment—Gene Duplication and the Origin and Evolution of Snake Venom Toxins
Hargreaves, A. D., Swain, M. T., Hegarty, M. J., Logan, D. W. & Mulley, J. F., 30 Gorff 2014, Yn: Genome Biology and Evolution. 6, 8, t. 2088-2095
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydTesting the Toxicofera: comparative reptile transcriptomics casts doubt on the single, early evolution of the reptile venom system
Hargreaves, A. D., Swain, M. T., Logan, D. W. & Mulley, J. F., 17 Hyd 2014, Yn: Toxicon. 92, t. 140-156
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydTranscriptomic analysis of the lesser spotted catshark (Scyliorhinus canicula) pancreas, liver and brain reveals molecular level conservation of vertebrate pancreas function
Mulley, J. F., Hargreaves, A. D., Hegarty, M. J., Heller, R. S. & Swain, M. T., 6 Rhag 2014, Yn: BMC Genomics. 15, 1074
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2010
- CyhoeddwydParallel retention of Pdx2 genes in cartilaginous fish and coelcanths.
Mulley, J. F. & Holland, P. W., 12 Mai 2010, Yn: Molecular Biology and Evolution. 27, 10, t. 2386-2391
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2009
- CyhoeddwydComparative genomics of chondrichthyan Hoxa clusters.
Mulley, J. F., Zhong, Y. F. & Holland, P. W., 2 Medi 2009, Yn: BMC Evolutionary Biology. 9, t. 218
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2008
- CyhoeddwydParaHox cluster evolution--hagfish and beyond
Furlong, R. F. & Mulley, J. F., 25 Hyd 2008, Yn: Zoological Science. 25, 10, t. 955-9 5 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl adolygu › adolygiad gan gymheiriaid
2006
- CyhoeddwydBreakup of a homeobox cluster after genome duplication in teleosts
Mulley, J. F., Chiu, C.-H. & Holland, P. W. H., 5 Gorff 2006, Yn: Proceedings of the National Academy of Sciences of the United States of America. 103, 27, t. 10369-72 4 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
2004
- CyhoeddwydComparative genomics: small genome, big insights
Mulley, J. & Holland, P., 21 Hyd 2004, Yn: Nature. 431, 7011, t. 916-7 2 t.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid - CyhoeddwydTrinucleotide microsatellite loci for the peppered moth (Biston betularia)
Daly, D., Waltham, K., Mulley, J., Watts, P., Rosin, A., Kemp, S. & Saccheri, I., Meh 2004, Yn: Molecular Ecology Notes. 4, 2, t. 179-181
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Gweithgareddau
2023
- Dynamic Anatomy: Evolutionary and Developmental Change through Time
25 Gorff 2023 – 27 Gorff 2023
Gweithgaredd: Cymryd rhan mewn cynhadledd Academaidd (Trefnydd)
Projectau
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01/06/2019 – 30/09/2023 (Wedi gorffen)
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01/02/2019 – 30/06/2020 (Wedi gorffen)
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Support for attendance at UFAW conference
01/11/2017 – 31/12/2017 (Wedi gorffen)
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Support for attendance at UFAW conference
01/11/2017 – 15/03/2018 (Wedi gorffen)
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Refining husbandry and welfare of desert rodents
01/02/2017 – 30/05/2018 (Wedi gorffen)
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01/06/2016 – 01/08/2019 (Wedi gorffen)
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Gene duplication & regulation & evolution & development of snake venom
01/04/2011 – 31/08/2012 (Wedi gorffen)
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The role of Pdx2 in pancreas development and function
01/02/2011 – 31/03/2013 (Wedi gorffen)
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Resources for the study of shark populations around North-West Wales
01/08/2010 – 31/08/2014 (Wedi gorffen)