Rhedir gan School of Medical Sciences
20.000 Credyd neu 10.000 Credyd ECTS
Trefnydd: Dr Gwyndaf Roberts
Students successfully completing this second year module should develop a conceptual understanding of how the different organelles and proteins contribute to the life cycle & functions of an eukaryotic cell. Disease examples and novel scientific developments are covered.
This module takes students on a journey through the eukaryotic cell. The content is arranged in 4 blocks, each block will be assessed at the end of the module by completion of a coursework essay and an examination.
Block 1: The Cell Biology of cell signalling: Ion-channel-coupled receptors, G protein coupled receptors and Receptor Tyrosine Kinases in health and disease
Block 2: Protein Homeostasis: The Endoplasmatic Reticulum, Golgi System, Lysosome (protein glycosylation, ER stress response, lysosomal storage disorders)
Block 3: The Mitochondrion: (basic functions, myopathies, apoptosis)
Block 4: The Cytoskeleton: (centrosome in dividing & postmitotic cells, microtubles, actin fibers, microcephaly, asymmetric cell division)
Category: D (40%-49%)
Knowledge is limited to key areas & principles with gaps. No evidence of background reading. Answers are poorly focussed with some irrelevant material and/or repetition. No original interpretation and ideas. Limited problem solving skills, poor time management. Many weaknesses in presentation and accuracy. Answers use mainly key phrases without explaining them. The mark reflects how wide the knowledge gaps are and how little explanation & context is provided.
Category: A (70%-100%)
Strong knowledge based on the lecture material. Evidence of background study and good explanation of the biological principles. Answers are focussed with a good structure. Arguments are presented coherently. Mostly free of errors. Some limited original interpretation. Well known links between topics are described. Good problem solving & time management skills.
Upper A (A+, A*)
Comprehensive knowledge & detailed understanding with clear evidence of background study. Highly focussed answer and well structured and supported by diagrams & tables. Very good explanation and relevant context included. Written for a reader who is not familiar with the topic. Logically presented and defended arguments. No factual errors. Original interpretation and novel links between topics are developed. Excellent problem solving & time management skills.
To obtain marks in the A+ and A* range, clear evidence of background reading has to be present. Top answers based on the lecture material return low A marks.
Category: B (60%-69%)
Sound knowledge of key areas & principles. The main areas are understood with some minor omissions. Limited evidence of background study. The answer is largely based on the lecture material. Answers are focussed on the question but also with some irrelevant material and weaknesses in structure. Arguments presented but lack sometimes coherence. No original interpretation & ideas. Only major links between topics are described. Evidence of problem solving & time management skills. Some weaknesses in presentation and accuracy.
C- i C+
Category: C (50%-59%)
Sound knowledge of key areas & principles. The main areas are understood with some minor omissions. No evidence of background study. The answer is only based on the lecture material. Answers are focussed on the question but are limited to statements which are not followed up by explanation or context. Answer may contain some irrelevant material and weaknesses in structure. Arguments presented but lack sometimes coherence. No original interpretation & ideas. Only major links between topics are described. No evidence of problem solving & time management skills. Some weaknesses in presentation and accuracy.
Demonstrate an appreciation of how the basic blueprint of a cell evolved to full-fill specialised functions. (Biosciences benchmarks: 6.4 subject knowledge & 4.2 intellectual skills)
Demonstrate a conceptual understanding of how the different organelles and compartments form a living eukaryotic cell. (Biosciences benchmarks: 6.4 subject knowledge & 4.2 intellectual skills)
Combine knowledge and understanding of individual cellular processes to explain normal cell function. (Biosciences benchmarks: 6.3 subject knowledge & 4.2 intellectual skills)
Interpret knowledge and understanding of cellular processes to explain the pathogenesis and origins of disease processes. (Biosciences benchmarks: 6.2 subject knowledge & 4.2 intellectual skills)
|GWAITH CWRS||Why it was worth a Nobel Prize - Letter to Nature||
Students will select one Nobel prize winner, from the Physiology or Medicine, or Chemistry categories. Students will then research the scientific background of the winner, select a key paper that contributed to them winning the prize. Finally students will construct an essay/paper, in the format of a Letter to Nature, which will summarise the background of the winner, the state of knowledge prior to the selected paper, the key points of the paper and finally the impact and knowledge post the paper.
Students will sit an exam consisting of two sections covering all topics discussed in the lectures: (A) 50 eMCQ style questions ; (B) short answer exam questions.
Strategaeth addysgu a dysgu
A series of lectures exploring the main cell organelles.
Review sessions towards the end of the module summarising the key points and concepts, and advise on revision.
Each student will select one Nobel Prize winner for Physiology or Medicine form the list available at https://www.nobelprize.org/nobel_prizes/medicine/laureates/
Students are expected to revise the lecture material and to engage with Cell Biology text books and other relevant resources during the module. The evidence of private study in both assignments informs the final module mark. The formation of study groups is encouraged.
- Llythrennedd - Medrusrwydd mewn darllen ac ysgrifennu drwy amrywiaeth o gyfryngau
- Rhifedd - Medrusrwydd wrth ddefnyddio rhifau ar lefelau priodol o gywirdeb
- Defnyddio cyfrifiaduron - Medrusrwydd wrth ddefnyddio ystod o feddalwedd cyfrifiadurol
- Hunanreolaeth - Gallu gweithio mewn ffordd effeithlon, prydlon a threfnus. Gallu edrych ar ganlyniadau tasgau a digwyddiadau, a barnu lefelau o ansawdd a phwysigrwydd
- Archwilio - Gallu ymchwilio ac ystyried dewisiadau eraill
- Adalw gwybodaeth - Gallu mynd at wahanol ac amrywiol ffynonellau gwybodaeth
- Sgiliau Rhyngbersonol - Gallu gofyn cwestiynau, gwrando'n astud ar atebion a'u harchwilio
- Dadansoddi Beirniadol & Datrys Problem - Gallu dadelfennu a dadansoddi problemau neu sefyllfaoedd cymhleth. Gallu canfod atebion i broblemau drwy ddadansoddiadau ac archwilio posibiliadau
- Cyflwyniad - Gallu cyflwyno gwybodaeth ac esboniadau yn glir i gynulleidfa. Trwy gyfryngau ysgrifenedig neu ar lafar yn glir a hyderus.
- Dadl - Gallu cyflwyno, trafod a chyfiawnhau barn neu lwybr gweithredu, naill ai gydag unigolyn neu mewn grwˆp ehangach
- Hunanymwybyddiaeth & Ystyried - Bod yn ymwybodol o'ch cryfderau, gwendidau, nodau ac amcanion eich hun. Gallu adolygu ,cloriannu a myfyrio'n rheolaidd ar eich perfformiad eich hun ac eraill.
Sgiliau pwnc penodol
Biomedical sciences graduates should be able to:
- recognise and apply subject-specific theories, paradigms, concepts or principles (for example, the relationship between genes and proteins, or the nature of essential similarities and differences between prokaryote and eukaryote cells)
- make evidence-based decisions
- obtain and integrate several lines of subject-specific evidence to formulate and test hypotheses
- apply subject knowledge and understanding to address familiar and unfamiliar problems
- receive and respond to a variety of sources of information: textual, numerical, verbal, graphical.
(QAA Biomedical Sciences (2015) benchmark: 4.2 Intellectual skills; 4.4 Analytical, data interpretation and problem solving skills)