Overview

Genomic instability, either inherited or acquired, drives many human disorders. But how do we know about this?

This module introduces students to the concepts of scientific work and communication by critical analysis of one of the two break-through publications which deepened our understanding of genetic aberrations and their link with disease development. Each paper will be introduced in lectures and the content will be further analysed in the context of the recent advances presented by experts in the field.

Students will present critical analysis and broad implications of the content of one of the papers in a NATURE-style News & Views summary. They will also write a critical analysis of an external seminar, focusing on the latest development in an important area in genome stability research.

Students will get guidance on how to write the News & Views summary and the critical essay.

Learning Outcomes

• Critically evaluate how genome instability contributes to human diseases at a molecular level.

• Critically evaluate primary research articles and demonstrate an ability to synthesise research findings in a broader context.

• Critique the various methodologies utilised in investigating genome instability.