Prof David Shepherd

• PhD: The role of GABA in controlling Synaptic function
  University of Manchester, 1980–1984
• BSc: Zoology
  University of Manchester, 1977–1980

I have two major research interests.

1. Understanding the developmental rules that control the assembly of neural circuits in insects
2. Using the fruit fly Drosophila to model the molecular mechanisms of neuruodgenerative diseases

I am open to direct contact to disucss PhD opportinities related to my research interests

2019

• PublishedDevelopmental organization of central neurons in the adult Drosophila ventral nervous system
  Shepherd, D., Sahota, V., Court, R., Williams, D. W. & Truman, J., 15 Oct 2019, In : Journal of Comparative Neurology. 527, 15, p. 2573-2598
  Research output: Contribution to journal › Article
• PublishedAn evaluation of Drosophila as a model system for studying tauopathies such as Alzheimer's disease
  Sivanantharajah, L., Mudher, A. & Shepherd, D., 1 May 2019, In : Journal of Neuroscience Methods. 319, May, p. 77-88 12 p.
  Research output: Contribution to journal › Article

2016

• PublishedPostembryonic lineages of the Drosophila ventral nervous system: Neuroglian expression reveals the adult hemilineage associated fiber tracts in the adult thoracic neuromeres
  Shepherd, D., Robin, H., Darren W, W. & James W, T., 1 Mar 2016, In : Journal of Comparative Neurology. 524, 13, p. 2677-2695 19 p.
  Research output: Contribution to journal › Article

2014

• PublishedCloning and expression analysis of Drosophila extracellular Cu Zn superoxide dismutase
  Blackney, M. J., Cox, R., Shepherd, D. & Parker, J. D., 23 Dec 2014, In : Bioscience reports. 34, 6, p. e00164
  Research output: Contribution to journal › Article

2012

• PublishedA GAL4-Driver Line Resource for Drosophila Neurobiology
  Jenett, A., Rubin, G., Ngo, T. T. B., Shepherd, D., Murphy, C., Dionne, H., Pfeiffer, B., Cavallaro, A., Hall, D., Jeter, J., Iyer, N., Fetter, D., Hausenfluck, J., Peng, H., Trautman, E. T., Svirskas, R. R., Meyers, E. W., Iwinski, Z. R., Aso, Y., DePasquale, G. M., Enos, A., Hulamm, P., Lam, S. C. B., Li, H-H., Laverty, T., Long, F., Qu, L., Murphy, S. D., Rokicki, C., Safford, T., Shaw, K., Simpson, J. H., Sowell, A., Tae, S., Yu, Y. & Zugates, C. T., 11 Oct 2012, In : Cell Reports. 2, 4, p. 991-1001 10 p.
  Research output: Contribution to journal › Article
• PublishedDisruption of Microtubule Integrity Initiates Mitosis during CNS Repair
  Bossing, T., Barros, C. S., Fischer, B., Russell, S. & Shepherd, D., 1 Aug 2012, In : Developmental Cell. 23, 2, p. 433-440
  Research output: Contribution to journal › Article

2010

• PublishedTranscriptional control of damage repair at the ventral midline of Drosophila melanogaster
  Bossing, T., Fischer, B., Russell, S. & Shepherd, D., Dec 2010, In : Journal of neurogenetics. 24, S1, p. 86-86
  Research output: Contribution to journal › Meeting Abstract
• PublishedSoluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo.
  Cowan, C. M., Bossing, T., Page, A., Shepherd, D. & Mudher, A., 1 Nov 2010, In : Acta Neuropathologica. 120, 5, p. 593-604
  Research output: Contribution to journal › Article
• PublishedInsights from Drosophila models of Alzheimer's disease.
  Cowan, C. M., Shepherd, D. & Mudher, A., 1 Aug 2010, In : Biochemical Society Transactions. 38, 4, p. 988-992
  Research output: Contribution to journal › Article
• PublishedAβ exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease.
  Folwell, J., Cowan, C. M., Ubhi, K. K., Shiabh, H., Newman, T. A., Shepherd, D. & Mudher, A., 1 Jun 2010, In : Experimental Neurology. 223, 2, p. 401-409
  Research output: Contribution to journal › Article
• PublishedDisruption of neuronal function by soluble hyperphosphorylated tau in Drosophila model of tauopathy.
  Cowan, C. M., Chee, F., Shepherd, D. & Mudher, A., 1 Apr 2010, In : Biochemical Society Transactions. 38, 2, p. 564-570
  Research output: Contribution to journal › Article

2008

• PublishedModelling neurodegenerative diseases in Drosophila
  Shepherd, D., Mudher, A. & Newman, T. A., 2008, In : SEB experimental biology series. 60, p. 1-7 7 p.
  Research output: Contribution to journal › Review article
• PublishedUsing Drosophila models to unravel pathogenic mechanisms that underlie neurodegeneration in tauopathies
  Mudher, A., Newman, T. A., Chee, F. & Shepherd, D., 2008, In : SEB experimental biology series. 60, p. 25-38 14 p.
  Research output: Contribution to journal › Review article

2007

• PublishedA comparison of the neuronal dysfunction caused by Drosophila tau and human tau in a Drosophila model of tauopathies
  Ubhi, K. K., Shaibah, H., Newman, T. A., Shepherd, D. & Mudher, A., Sep 2007, In : Invertebrate neuroscience : IN. 7, 3, p. 165-71 7 p.
  Research output: Contribution to journal › Article

2006

• PublishedImmunolocalisation of the D-melanogaster Nramp homologue Malvolio to gut and Malpighian tubules provides evidence that Malvolio and Nramp2 are orthologous
  Folwell, J. L., Barton, C. H. & Shepherd, D., 15 May 2006, In : Journal of Experimental Biology. 209, 10, p. 1988-1995
  Research output: Contribution to journal › Article
• PublishedModelling axonal injury using Drosophila
  Newman, T., Shaibah, H. & Shepherd, D., Apr 2006, In : Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology. 143, 4, p. S115-S115
  Research output: Contribution to journal › Meeting Abstract
• PublishedModelling human neurodegenerative diseases in Drosophila
  Shepherd, D., Newman, T. A., Chee, F., Cuttle, M. & Mudher, A., Apr 2006, In : Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology. 143, 4, p. S113-S113
  Research output: Contribution to journal › Meeting Abstract

2005

• PublishedOver-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions
  Chee, F. C., Mudher, A., Cuttle, M. F., Newman, T. A., MacKay, D., Lovestone, S. & Shepherd, D., Dec 2005, In : Neurobiology of disease. 20, 3, p. 918-28 11 p.
  Research output: Contribution to journal › Article
• PublishedSelf-destruct programs in the processes of developing neurons
  Shepherd, D. & Perry, V. H., 2005, In : CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY, VOL 65. 65, p. 149-167
  Research output: Contribution to journal › Review article

2004

• PublishedDevelopmental architecture of adult-specific lineages in the ventral CNS of Drosophila
  Truman, J. W., Schuppe, H., Shepherd, D. & Williams, D. W., Oct 2004, In : Development. 131, 20, p. 5167-84 18 p.
  Research output: Contribution to journal › Article
• PublishedAxonal transport and behavioural defects in Drosophila expressing wild-type and mutant tau
  Mudher, A. K., MacKay, D., Chee, F., Shepherd, D. & Lovestone, S., Jul 2004, In : Neurobiology of Aging. 25, S2, p. S253-S253
  Research output: Contribution to journal › Meeting Abstract
• PublishedEndocytosis, synaptic transmission and mitochondria are defective in the neuromuscular junction in drosophila larvae over-expressing tau
  Chee, F. C., Mudher, A. K., Lovestone, S. & Shepherd, D., Jul 2004, In : Neurobiology of Aging. 25, p. S78-S78
  Research output: Contribution to journal › Meeting Abstract
• PublishedGSK-3: Its role in tau phosphorylation and synaptic plasticity
  Lovestone, S., Chee, F., Killick, R., MacKay, D., Markevich, V., Mudher, A., Shepherd, D. & Stephenson, J., Jul 2004, In : Neurobiology of Aging. 25, S2, p. S8-S8
  Research output: Contribution to journal › Meeting Abstract
• PublishedGSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila
  Mudher, A., Shepherd, D., Newman, T. A., Mildren, P., Jukes, J. P., Squire, A., Mears, A., Berg, S., MacKay, D., Asuni, A. A., Bhat, R. & Lovestone, S., May 2004, In : Molecular Psychiatry. 9, 5, p. 522-30 9 p.
  Research output: Contribution to journal › Article

2003

• PublishedNeuroinformatics in model organisms
  Armstrong, J. D., Goddard, N. H. & Shepherd, D., 12 Dec 2003, In : Journal of neurogenetics. 17, 2-3, p. 103-16 14 p.
  Research output: Contribution to journal › Article

2002

• PublishedPersistent larval sensory neurones are required for the normal development of the adult sensory afferent projections in Drosophila
  Williams, D. W. & Shepherd, D., Feb 2002, In : Development. 129, 3, p. 617-24 8 p.
  Research output: Contribution to journal › Article

2000

• PublishedTau and tau reporters disrupt central projections of sensory neurons in Drosophila
  Williams, D. W., Tyrer, M. & Shepherd, D., 25 Dec 2000, In : Journal of Comparative Neurology. 428, 4, p. 630-640
  Research output: Contribution to journal › Article
• PublishedConfocal quality imaging of afferent neurons from semi-thin sections of Drosophila ganglia
  Tyrer, N. M., Maddison, J., Shepherd, D. & Williams, D. W., 22 Dec 2000, In : Neuroscience Letters. 296, 2-3, p. 93-6 4 p.
  Research output: Contribution to journal › Article
• PublishedMethods for imaging labeled neurons together with neuropil features in Drosophila
  Tyrer, N. M., Shepherd, D. & Williams, D. W., Nov 2000, In : JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY. 48, 11, p. 1575-1581
  Research output: Contribution to journal › Article
• PublishedGlial dependent survival of neurons in Drosophila
  Shepherd, D., May 2000, In : BioEssays. 22, 5, p. 407-409
  Research output: Contribution to journal › Article

1998

• PublishedDisconnected mutants show disruption to the central projections of proprioceptive neurons in Drosophila melanogaster
  Glossop, N. R. & Shepherd, D., 5 Sep 1998, In : Journal of neurobiology. 36, 3, p. 337-47 11 p.
  Research output: Contribution to journal › Article
• PublishedDynamic developmental expression of smallminded, a Drosophila gene required for cell division
  Long, A. R., Wilkins, J. C. & Shepherd, D., Aug 1998, In : Mechanisms of development. 76, 1-2, p. 33-43 11 p.
  Research output: Contribution to journal › Article
• PublishedIsolation and characterisation of smallminded, a Drosophila gene encoding a new member of the Cdc48p/VCP subfamily of AAA proteins
  Long, A. R., Yang, M., Kaiser, K. & Shepherd, D., 27 Feb 1998, In : Gene. 208, 2, p. 191-9 9 p.
  Research output: Contribution to journal › Article

1996

• PublishedCentral projections of persistent larval sensory neurons prefigure adult sensory pathways in the CNS of Drosophila
  Shepherd, D. & Smith, S. A., Aug 1996, In : Development. 122, 8, p. 2375-2384
  Research output: Contribution to journal › Article
• PublishedCentral afferent projections of proprioceptive sensory neurons in Drosophila revealed with the enhancer-trap technique
  Smith, S. A. & Shepherd, D., 8 Jan 1996, In : Journal of Comparative Neurology. 364, 2, p. 311-323
  Research output: Contribution to journal › Article

1995

• PublishedMorphogenesis of the branching pattern of a group of spiking local interneurons in relation to the organization of embryonic sensory neuropils in locust
  Leitch, B., Shepherd, D. & Laurent, G., 29 Sep 1995, In : Philosophical Transactions of The Royal Society B: Biological Sciences. 349, 1330, p. 433-447
  Research output: Contribution to journal › Article

1994

• PublishedHormones, neuroblasts and the adult insect
  Shepherd, D., Jul 1994, In : BioEssays. 16, 7, p. 457-459
  Research output: Contribution to journal › Comment/debate

1992

• PublishedEmbryonic development of synapses on spiking local interneurones in locust.
  Leitch, B., Laurent, G. & Shepherd, D., 8 Oct 1992, In : Journal of Comparative Neurology. 324, 2, p. 213-236
  Research output: Contribution to journal › Article
• PublishedEmbryonic development of a population of spiking local interneurones in the locust (Schistocerca gregaria).
  Shepherd, D. & Laurent, G., 15 May 1992, In : Journal of Comparative Neurology. 319, 3, p. 438-453
  Research output: Contribution to journal › Article

1991

• PublishedNeural repair and glial proliferation: parallels with gliogenesis in insects
  Smith, P. J. S., Shepherd, D. & Edwards, J. S., Feb 1991, In : BioEssays : news and reviews in molecular, cellular and developmental biology. 13, 2, p. 65-72 8 p.
  Research output: Contribution to journal › Review article

1990

• PublishedSpatial and temporal patterns of neurogenesis in the embryo of the locust (Schistocerca gregaria)
  Shepherd, D. & Bate, C. M., Jan 1990, In : Development. 108, 1, p. 83-96
  Research output: Contribution to journal › Article

1988

• PublishedSynaptic rearrangement during postembryonic development in the cricket.
  Chiba, A., Shepherd, D. & Murphey, RK., 13 May 1988, In : Science. 240, 4854, p. 901-905
  Research output: Contribution to journal › Article
• PublishedThe synaptic origins of receptive field properties in the cricket cercal sensory system
  Shepherd, D., Kämper, G. & Murphey, R. K., 1988, In : JOURNAL OF COMPARATIVE PHYSIOLOGY A-SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY. 162, 1, p. 1-11
  Research output: Contribution to journal › Article

1986

• PublishedCompetition regulates the efficacy of an identified synapse in crickets.
  Shepherd, D. & Murphey, R. K., Nov 1986, In : Journal of Neuroscience. 6, 11, p. 3152-3160
  Research output: Contribution to journal › Article

• Santander Mobility grant (Santander Award 2)

  01/10/2016 – 30/09/2017 (Finished)

• Early Career Award

  01/10/2012 – 30/09/2017 (Finished)

• Early Career Award

  01/10/2012 – 30/09/2017 (Finished)

• Santander Mobility grant (Santander Award 2)

  01/10/2012 – 30/09/2017 (Finished)

• Santander Mobility grant (Santander Award 2)

  01/10/2012 – 30/09/2017 (Finished)

• Santander Mobility grant (Santander Award 2)

  01/10/2012 – 30/09/2017 (Finished)

• Santander Mobility grant (Santander Award 2)

  01/10/2012 – 30/09/2017 (Finished)

• Santander Mobility grant (Santander Award 2)

  01/10/2012 – 30/09/2017 (Finished)

• Santander Mobility grant (Santander Award 2)

  01/10/2012 – 30/09/2017 (Finished)

• Santander Mobility grant (Santander Award 2)

  01/10/2012 – 30/09/2017 (Finished)

• Santander Mobility grant (Santander Award 2)

  01/10/2012 – 30/09/2017 (Finished)