Prof David Shepherd
Professor of Developmental Neurobiology
–
Prof David Shepherd
Professor of Developmental Neurobiology
School of Natural Sciences
Level 2 ECW
I can speak some Welsh
Email: d.shepherd@bangor.ac.uk
Phone: 01248 382436
Mobile phone: 07540 799752
Level 2 ECW Building
Qualifications
- PhD: The role of GABA in controlling Synaptic function
University of Manchester, 1980–1984 - BSc: Zoology
University of Manchester, 1977–1980
Research Interests
I have two major research interests.
- Understanding the developmental rules that control the assembly of neural circuits in insects
- Using the fruit fly Drosophila to model the molecular mechanisms of neuruodgenerative diseases
Postgraduate Project Opportunities
I am open to direct contact to disucss PhD opportinities related to my research interests
Publications
2020
- PublishedA Systematic Nomenclature for the Drosophila Ventral Nerve Cord
Court, R., Namiki, S., Armstrong, J. D., Boerner, J., Card, G., Costa, M., Dickinson, M., Duch, C., Korff, W., Mann, R., Merritt, D., Murphey, R., Seeds, A., Shirangi, T., Simpson, J., Truman, J. W., Tuthill, J., Williams, D. W. & Shepherd, D., 23 Sep 2020, In : Neuron. 107, 6, p. 1071-1079
Research output: Contribution to journal › Article - PublishedCentral processing of leg proprioception in Drosophila
Agrawal, S., Seattle, U. O., Sustar, A., Gurung, P., Shepherd, D., Truman, J. & Tuthill, J., 21 Dec 2020, In : Elife. 9, 32 p., 60299.
Research output: Contribution to journal › Article
2019
- PublishedAn evaluation of Drosophila as a model system for studying tauopathies such as Alzheimer's disease
Sivanantharajah, L., Mudher, A. & Shepherd, D., 1 May 2019, In : Journal of Neuroscience Methods. 319, May, p. 77-88 12 p.
Research output: Contribution to journal › Article - PublishedDevelopmental organization of central neurons in the adult Drosophila ventral nervous system
Shepherd, D., Sahota, V., Court, R., Williams, D. W. & Truman, J., 15 Oct 2019, In : Journal of Comparative Neurology. 527, 15, p. 2573-2598
Research output: Contribution to journal › Article
2016
- PublishedPostembryonic lineages of the Drosophila ventral nervous system: Neuroglian expression reveals the adult hemilineage associated fiber tracts in the adult thoracic neuromeres
Shepherd, D., Robin, H., Darren W, W. & James W, T., 1 Mar 2016, In : Journal of Comparative Neurology. 524, 13, p. 2677-2695 19 p.
Research output: Contribution to journal › Article
2014
- PublishedCloning and expression analysis of Drosophila extracellular Cu Zn superoxide dismutase
Blackney, M. J., Cox, R., Shepherd, D. & Parker, J. D., 23 Dec 2014, In : Bioscience reports. 34, 6, p. e00164
Research output: Contribution to journal › Article
2012
- PublishedA GAL4-Driver Line Resource for Drosophila Neurobiology
Jenett, A., Rubin, G., Ngo, T. T. B., Shepherd, D., Murphy, C., Dionne, H., Pfeiffer, B., Cavallaro, A., Hall, D., Jeter, J., Iyer, N., Fetter, D., Hausenfluck, J., Peng, H., Trautman, E. T., Svirskas, R. R., Meyers, E. W., Iwinski, Z. R., Aso, Y., DePasquale, G. M., Enos, A., Hulamm, P., Lam, S. C. B., Li, H-H., Laverty, T., Long, F., Qu, L., Murphy, S. D., Rokicki, C., Safford, T., Shaw, K., Simpson, J. H., Sowell, A., Tae, S., Yu, Y. & Zugates, C. T., 11 Oct 2012, In : Cell Reports. 2, 4, p. 991-1001 10 p.
Research output: Contribution to journal › Article - PublishedDisruption of Microtubule Integrity Initiates Mitosis during CNS Repair
Bossing, T., Barros, C. S., Fischer, B., Russell, S. & Shepherd, D., 1 Aug 2012, In : Developmental Cell. 23, 2, p. 433-440
Research output: Contribution to journal › Article
2010
- PublishedAβ exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease.
Folwell, J., Cowan, C. M., Ubhi, K. K., Shiabh, H., Newman, T. A., Shepherd, D. & Mudher, A., 1 Jun 2010, In : Experimental Neurology. 223, 2, p. 401-409
Research output: Contribution to journal › Article - PublishedDisruption of neuronal function by soluble hyperphosphorylated tau in Drosophila model of tauopathy.
Cowan, C. M., Chee, F., Shepherd, D. & Mudher, A., 1 Apr 2010, In : Biochemical Society Transactions. 38, 2, p. 564-570
Research output: Contribution to journal › Article - PublishedInsights from Drosophila models of Alzheimer's disease.
Cowan, C. M., Shepherd, D. & Mudher, A., 1 Aug 2010, In : Biochemical Society Transactions. 38, 4, p. 988-992
Research output: Contribution to journal › Article - PublishedSoluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo.
Cowan, C. M., Bossing, T., Page, A., Shepherd, D. & Mudher, A., 1 Nov 2010, In : Acta Neuropathologica. 120, 5, p. 593-604
Research output: Contribution to journal › Article - PublishedTranscriptional control of damage repair at the ventral midline of Drosophila melanogaster
Bossing, T., Fischer, B., Russell, S. & Shepherd, D., Dec 2010, In : Journal of Neurogenetics. 24, S1, p. 86-86
Research output: Contribution to journal › Meeting Abstract
2008
- PublishedModelling neurodegenerative diseases in Drosophila
Shepherd, D., Mudher, A. & Newman, T. A., 2008, In : SEB experimental biology series. 60, p. 1-7 7 p.
Research output: Contribution to journal › Review article - PublishedUsing Drosophila models to unravel pathogenic mechanisms that underlie neurodegeneration in tauopathies
Mudher, A., Newman, T. A., Chee, F. & Shepherd, D., 2008, In : SEB experimental biology series. 60, p. 25-38 14 p.
Research output: Contribution to journal › Review article
2007
- PublishedA comparison of the neuronal dysfunction caused by Drosophila tau and human tau in a Drosophila model of tauopathies
Ubhi, K. K., Shaibah, H., Newman, T. A., Shepherd, D. & Mudher, A., Sep 2007, In : Invertebrate neuroscience. 7, 3, p. 165-71 7 p.
Research output: Contribution to journal › Article
2006
- PublishedImmunolocalisation of the D-melanogaster Nramp homologue Malvolio to gut and Malpighian tubules provides evidence that Malvolio and Nramp2 are orthologous
Folwell, J. L., Barton, C. H. & Shepherd, D., 15 May 2006, In : Journal of Experimental Biology. 209, 10, p. 1988-1995
Research output: Contribution to journal › Article - PublishedModelling axonal injury using Drosophila
Newman, T., Shaibah, H. & Shepherd, D., Apr 2006, In : Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology. 143, 4, p. S115-S115
Research output: Contribution to journal › Meeting Abstract - PublishedModelling human neurodegenerative diseases in Drosophila
Shepherd, D., Newman, T. A., Chee, F., Cuttle, M. & Mudher, A., Apr 2006, In : Comparative Biochemistry and Physiology - Part A: Molecular and Integrative Physiology. 143, 4, p. S113-S113
Research output: Contribution to journal › Meeting Abstract
2005
- PublishedOver-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions
Chee, F. C., Mudher, A., Cuttle, M. F., Newman, T. A., MacKay, D., Lovestone, S. & Shepherd, D., Dec 2005, In : Neurobiology of disease. 20, 3, p. 918-28 11 p.
Research output: Contribution to journal › Article - PublishedSelf-destruct programs in the processes of developing neurons
Shepherd, D. & Perry, V. H., 2005, In : Current Topics in Developmental Biology. 65, p. 149-167
Research output: Contribution to journal › Review article
2004
- PublishedAxonal transport and behavioural defects in Drosophila expressing wild-type and mutant tau
Mudher, A. K., MacKay, D., Chee, F., Shepherd, D. & Lovestone, S., Jul 2004, In : Neurobiology of Aging. 25, S2, p. S253-S253
Research output: Contribution to journal › Meeting Abstract - PublishedDevelopmental architecture of adult-specific lineages in the ventral CNS of Drosophila
Truman, J. W., Schuppe, H., Shepherd, D. & Williams, D. W., Oct 2004, In : Development. 131, 20, p. 5167-84 18 p.
Research output: Contribution to journal › Article - PublishedEndocytosis, synaptic transmission and mitochondria are defective in the neuromuscular junction in drosophila larvae over-expressing tau
Chee, F. C., Mudher, A. K., Lovestone, S. & Shepherd, D., Jul 2004, In : Neurobiology of Aging. 25, p. S78-S78
Research output: Contribution to journal › Meeting Abstract - PublishedGSK-3: Its role in tau phosphorylation and synaptic plasticity
Lovestone, S., Chee, F., Killick, R., MacKay, D., Markevich, V., Mudher, A., Shepherd, D. & Stephenson, J., Jul 2004, In : Neurobiology of Aging. 25, S2, p. S8-S8
Research output: Contribution to journal › Meeting Abstract - PublishedGSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila
Mudher, A., Shepherd, D., Newman, T. A., Mildren, P., Jukes, J. P., Squire, A., Mears, A., Berg, S., MacKay, D., Asuni, A. A., Bhat, R. & Lovestone, S., May 2004, In : Molecular Psychiatry. 9, 5, p. 522-30 9 p.
Research output: Contribution to journal › Article
2003
- PublishedNeuroinformatics in model organisms
Armstrong, J. D., Goddard, N. H. & Shepherd, D., 12 Dec 2003, In : Journal of Neurogenetics. 17, 2-3, p. 103-16 14 p.
Research output: Contribution to journal › Article
2002
- PublishedPersistent larval sensory neurones are required for the normal development of the adult sensory afferent projections in Drosophila
Williams, D. W. & Shepherd, D., Feb 2002, In : Development. 129, 3, p. 617-24 8 p.
Research output: Contribution to journal › Article
2000
- PublishedConfocal quality imaging of afferent neurons from semi-thin sections of Drosophila ganglia
Tyrer, N. M., Maddison, J., Shepherd, D. & Williams, D. W., 22 Dec 2000, In : Neuroscience Letters. 296, 2-3, p. 93-6 4 p.
Research output: Contribution to journal › Article - PublishedGlial dependent survival of neurons in Drosophila
Shepherd, D., May 2000, In : BioEssays. 22, 5, p. 407-409
Research output: Contribution to journal › Article - PublishedMethods for imaging labeled neurons together with neuropil features in Drosophila
Tyrer, N. M., Shepherd, D. & Williams, D. W., Nov 2000, In : Journal of Histochemistry and Cytochemistry. 48, 11, p. 1575-1581
Research output: Contribution to journal › Article - PublishedTau and tau reporters disrupt central projections of sensory neurons in Drosophila
Williams, D. W., Tyrer, M. & Shepherd, D., 25 Dec 2000, In : Journal of Comparative Neurology. 428, 4, p. 630-640
Research output: Contribution to journal › Article
1998
- PublishedDisconnected mutants show disruption to the central projections of proprioceptive neurons in Drosophila melanogaster
Glossop, N. R. & Shepherd, D., 5 Sep 1998, In : Journal of neurobiology. 36, 3, p. 337-47 11 p.
Research output: Contribution to journal › Article - PublishedDynamic developmental expression of smallminded, a Drosophila gene required for cell division
Long, A. R., Wilkins, J. C. & Shepherd, D., Aug 1998, In : Mechanisms of development. 76, 1-2, p. 33-43 11 p.
Research output: Contribution to journal › Article - PublishedIsolation and characterisation of smallminded, a Drosophila gene encoding a new member of the Cdc48p/VCP subfamily of AAA proteins
Long, A. R., Yang, M., Kaiser, K. & Shepherd, D., 27 Feb 1998, In : Gene. 208, 2, p. 191-9 9 p.
Research output: Contribution to journal › Article
1996
- PublishedCentral afferent projections of proprioceptive sensory neurons in Drosophila revealed with the enhancer-trap technique
Smith, S. A. & Shepherd, D., 8 Jan 1996, In : Journal of Comparative Neurology. 364, 2, p. 311-323
Research output: Contribution to journal › Article - PublishedCentral projections of persistent larval sensory neurons prefigure adult sensory pathways in the CNS of Drosophila
Shepherd, D. & Smith, S. A., Aug 1996, In : Development. 122, 8, p. 2375-2384
Research output: Contribution to journal › Article
1995
- PublishedMorphogenesis of the branching pattern of a group of spiking local interneurons in relation to the organization of embryonic sensory neuropils in locust
Leitch, B., Shepherd, D. & Laurent, G., 29 Sep 1995, In : Philosophical Transactions of The Royal Society B: Biological Sciences. 349, 1330, p. 433-447
Research output: Contribution to journal › Article
1994
- PublishedHormones, neuroblasts and the adult insect
Shepherd, D., Jul 1994, In : BioEssays. 16, 7, p. 457-459
Research output: Contribution to journal › Comment/debate
1992
- PublishedEmbryonic development of a population of spiking local interneurones in the locust (Schistocerca gregaria).
Shepherd, D. & Laurent, G., 15 May 1992, In : Journal of Comparative Neurology. 319, 3, p. 438-453
Research output: Contribution to journal › Article - PublishedEmbryonic development of synapses on spiking local interneurones in locust.
Leitch, B., Laurent, G. & Shepherd, D., 8 Oct 1992, In : Journal of Comparative Neurology. 324, 2, p. 213-236
Research output: Contribution to journal › Article
1991
- PublishedNeural repair and glial proliferation: parallels with gliogenesis in insects
Smith, P. J. S., Shepherd, D. & Edwards, J. S., Feb 1991, In : BioEssays : news and reviews in molecular, cellular and developmental biology. 13, 2, p. 65-72 8 p.
Research output: Contribution to journal › Review article
1990
- PublishedSpatial and temporal patterns of neurogenesis in the embryo of the locust (Schistocerca gregaria)
Shepherd, D. & Bate, C. M., Jan 1990, In : Development. 108, 1, p. 83-96
Research output: Contribution to journal › Article
1988
- PublishedSynaptic rearrangement during postembryonic development in the cricket.
Chiba, A., Shepherd, D. & Murphey, RK., 13 May 1988, In : Science. 240, 4854, p. 901-905
Research output: Contribution to journal › Article - PublishedThe synaptic origins of receptive field properties in the cricket cercal sensory system
Shepherd, D., Kämper, G. & Murphey, R. K., 1988, In : Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology. 162, 1, p. 1-11
Research output: Contribution to journal › Article
1986
- PublishedCompetition regulates the efficacy of an identified synapse in crickets.
Shepherd, D. & Murphey, R. K., Nov 1986, In : Journal of Neuroscience. 6, 11, p. 3152-3160
Research output: Contribution to journal › Article
Projects
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Santander Mobility grant (Santander Award 2)
01/10/2016 – 30/09/2017 (Finished)
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01/10/2012 – 30/09/2017 (Finished)
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01/10/2012 – 30/09/2017 (Finished)
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Santander Mobility grant (Santander Award 2)
01/10/2012 – 30/09/2017 (Finished)
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Santander Mobility grant (Santander Award 2)
01/10/2012 – 30/09/2017 (Finished)
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Santander Mobility grant (Santander Award 2)
01/10/2012 – 30/09/2017 (Finished)
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Santander Mobility grant (Santander Award 2)
01/10/2012 – 30/09/2017 (Finished)
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Santander Mobility grant (Santander Award 2)
01/10/2012 – 30/09/2017 (Finished)
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Santander Mobility grant (Santander Award 2)
01/10/2012 – 30/09/2017 (Finished)
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Santander Mobility grant (Santander Award 2)
01/10/2012 – 30/09/2017 (Finished)
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Santander Mobility grant (Santander Award 2)
01/10/2012 – 30/09/2017 (Finished)