Dr Christopher Staples
Senior Lecturer in Biomedical Sciences (Cancer Biology)
–
Cymwysterau
- PhD: Regulation of MAP kinase phosphatases
University of Dundee, 2006–2010
Addysgu ac Arolygiaeth
Teaching Credits
MSE-3016 Pathophysiology (10 credits) - Module Organiser
MSE-2025 Molecular Biology and Biochemistry (10 credits)
MSE-3013 Third Year Research Project
MSE-4025 Dissertation
Teaching and Supervision Roles
Undergraduate project/dissertation supervision. Supervision of PhD, MSc and MRes students.
Other roles
College representative on Research Concordat Committee
External and internal viva voce examiner
Teaching and Scholarship Awards
PGCertHE Stage 1 (2017)
PGCertHE Stage 2 (2018)
Fellow of the Higher Education Academy (HEA)
Diddordebau Ymchwil
Work in the Staples laboratory focuses largely on the characterisation of novel genome stability factors. Genome instability and DNA damage are central pathogenic mechanisms involved in cancer predisposition, premature ageing and neurodegeneration. Indeed, some cancer therapies target cancer-specific defects in DNA repair or replication fork protection mechanisms, and as such a complete understanding of such mechanisms is a major asset in the fight against cancer.
We have identified several novel DNA repair and replication fork protection factors, and our aim is to gain mechanistic insight into the function of these largely unstudied proteins with the ultimate goal of using this knowledge to design novel cancer therapies and/or predict therapeutic response.
Cyfleoedd Project Ôl-radd
Cyhoeddiadau
2020
- Cyhoeddwydjava.lang.NullPointerException
2017
- Cyhoeddwydjava.lang.NullPointerException
2016
- Cyhoeddwydjava.lang.NullPointerException
- Cyhoeddwydjava.lang.NullPointerException
- Cyhoeddwydjava.lang.NullPointerException
2014
- Cyhoeddwydjava.lang.NullPointerException
- Cyhoeddwydjava.lang.NullPointerException
2011
- Cyhoeddwydjava.lang.NullPointerException
2010
- Cyhoeddwydjava.lang.NullPointerException
2009
- Cyhoeddwydjava.lang.NullPointerException
2008
- Cyhoeddwydjava.lang.NullPointerException
2007
- Cyhoeddwydjava.lang.NullPointerException
Gweithgareddau
2021
- BBSRC reviewer
20 Meh 2021
Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr) - The Role of HERC2 in Ciliogenesis
Invited talk at the 26th UK Cilia Network Symposium
17 Mai 2021
Gweithgaredd: Cyflwyniad llafar (Siaradwr) - NWCR Scientific Committee Membership
Member of scientific panel
9 Mai 2021 →
Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr) - Peer reviewer for the Humane Research Trust
9 Mai 2021
Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr)
2020
- DNA Repair (Cyfnodolyn)
Peer reviewer
7 Tach 2020
Gweithgaredd: Adolygu cyhoeddiadau cymheiriaid (Aelod o fwrdd golygyddol) - Peer-reviewer for UKRI Future Leaders Fellowships
Peer-reviewer for UKRI Future Leaders Fellowships
25 Hyd 2020
Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr) - Molecular Oncology (Cyfnodolyn)
Peer review
11 Medi 2020
Gweithgaredd: Adolygu cyhoeddiadau cymheiriaid (Aelod o fwrdd golygyddol) - BBSRC Peer Review
Reviewed a BBSRC Responsive Mode Application
31 Awst 2020
Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr) - Internal Examiner for PhD Viva
21 Ebr 2020
Gweithgaredd: Arholiad (Arholwr) - Chair for PhD Viva
2 Ebr 2020
Gweithgaredd: Arholiad (Arholwr) - Peer review
Provided peer review for a BBSRC project grant application
4 Maw 2020
Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr) - PLoS Biology (Cyfnodolyn)
Acted as peer reviewer
7 Ion 2020
Gweithgaredd: Adolygu cyhoeddiadau cymheiriaid (Aelod o fwrdd golygyddol)
2019
- External examiner for PhD candidate in Lancaster
Supervised by Nikki Copeland
13 Meh 2019
Gweithgaredd: Arholiad (Arholwr) - Examined Prof Ciaran Morrisons PhD student (Galway)
External examiner
4 Meh 2019
Gweithgaredd: Arholiad (Arholwr) - MRNIP is a novel replication fork protection factor
15 min talk at international conference
2019
Gweithgaredd: Cyflwyniad llafar (Siaradwr)
2018
- Novel players in replication fork protection
Invited speaker to research seminar series
18 Maw 2018
Gweithgaredd: Cyflwyniad llafar (Siaradwr) - External examiner for MRes viva
29 Ion 2018
Gweithgaredd: Arholiad (Arholwr)
2017
- Internal Examiner for PhD viva
9 Tach 2017
Gweithgaredd: Arholiad (Arholwr) - The role of MRNIP in DNA repair
Invited speaker to research seminar series
11 Mai 2017
Gweithgaredd: Cyflwyniad llafar (Siaradwr)
Projectau
-
Daughter strand gaps as crucial determinants of therapeutic response
01/10/2022 – 31/10/2025 (Wrthi'n gweithredu)
-
KESS II MRes with NWCR - BUK2E089
01/10/2022 – 31/10/2023 (Wrthi'n gweithredu)
-
KESS II MRes with BEE Robotics BUK2E081
01/07/2022 – 31/10/2023 (Wrthi'n gweithredu)
-
HEFCW HEIR COVID extension to UKRI FLF MRC bid (F008177, R49R01, MR/S034579/1)
01/05/2021 – 31/08/2021 (Wedi gorffen)
-
KESS II MRes with North West Cancer Research BUK2225
01/01/2021 – 30/11/2022 (Wedi gorffen)
-
KESS II East Phd with North West Cancer Research BUK2E019
01/02/2020 – 31/07/2023 (Wrthi'n gweithredu)
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The role of MRNIP in replication fork stabilisation and DSB repair
01/12/2019 – 31/12/2023 (Wrthi'n gweithredu)
-
Potential roles of MRNIP and IFI16 in linking oncogene-induced replication
01/07/2019 – 21/09/2022 (Wedi gorffen)
-
Replication fork reversal and stability (UNS87415 Mr Anuj Narwal)
01/06/2019 – 01/08/2019 (Wedi gorffen)
-
Investigation of novel regulators of genome stability
01/01/2019 – 28/02/2023 (Wedi gorffen)
-
Autophagy dependent survival following Mec1(ATM/ATR) inactivation
01/05/2018 – 31/07/2023 (Wrthi'n gweithredu)
-
Role of RadIP, a novel DNA repair factor in the DNA damage response to chemotherapy.
01/11/2016 – 31/08/2020 (Wedi gorffen)
-
Targeting CtIP to sensitise cancer cells to DNA-damaging agents
01/10/2016 – 31/07/2018 (Wedi gorffen)
-
Therapeutically relevant novel links between DNA damage and ciliogenesis
01/10/2016 – 04/02/2023 (Wedi gorffen)