• PhD: Regulation of MAP kinase phosphatases
  University of Dundee, 2006–2010

Teaching Credits

MSE-3016 Pathophysiology (10 credits) - Module Organiser

MSE-2025 Molecular Biology and Biochemistry (10 credits) 

MSE-3013 Third Year Research Project 

MSE-4025 Dissertation

Teaching and Supervision Roles

Undergraduate project/dissertation supervision. Supervision of PhD, MSc and MRes students.

Other roles

College representative on Research Concordat Committee

External and internal viva voce examiner

Teaching and Scholarship Awards

PGCertHE Stage 1 (2017)

PGCertHE Stage 2 (2018)

Fellow of the Higher Education Academy (HEA)

Work in the Staples laboratory focuses largely on the characterisation of novel genome stability factors. Genome instability and DNA damage are central pathogenic mechanisms involved in cancer predisposition, premature ageing and neurodegeneration. Indeed, some cancer therapies target cancer-specific defects in DNA repair or replication fork protection mechanisms, and as such a complete understanding of such mechanisms is a major asset in the fight against cancer.

We have identified several novel DNA repair and replication fork protection factors, and our aim is to gain mechanistic insight into the function of these largely unstudied proteins with the ultimate goal of using this knowledge to design novel cancer therapies and/or predict therapeutic response.

2023

• CyhoeddwydRuthenium(II) Polypyridyl Complexes as FRET Donors: Structure- and Sequence-Selective DNA-Binding and Anticancer Properties
  Elgar, C. E., Yusoh, N. A., Tiley, P. R., Kolozsvári, N., Bennett, L., Gamble, A., Péan, E. V., Davies, M. L., Staples, C., Ahmad, H. & Gill, M. R., 18 Ion 2023, Yn: Journal of the American Chemical Society. 145, 2, t. 1236-1246 11 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2020

• CyhoeddwydMRNIP is a replication fork protection factor
  Bennett, L., Wilkie, A., Antonopoulou, E., Ceppi, I., Sanchez, A., Vernon, E., Gamble, A., Myers, K. N., Collis, S. J., Cejka, P. & Staples, C., 10 Gorff 2020, Yn: Science Advances. 6, 28, 10 t., eaba5974.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2017

• CyhoeddwydApproaches for Identifying Novel Targets in Precision Medicine: Lessons from DNA Repair
  Williams, D. T. & Staples, C., 25 Awst 2017, Personalised Medicine. El-Khamisy, S. (gol.). Springer, Cyfrol 1007. t. 1-16 16 t. (Advances in Experimental Medicine and Biology).
  Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion Cynhadledd › Pennod

2016

• CyhoeddwydHuman CDK18 promotes replication stress signaling and genome stability
  Barone, G., Staples, C. J., Ganesh, A., Patterson, K. W., Bryne, D. P., Myers, K. N., Patil, A. A., Eyers, C. E., Maslen, S., Skehel, J. M., Eyers, P. A. & Collis, S. J., 14 Hyd 2016, Yn: Nucleic Acids Research. 44, 18, t. 8772-8785 14 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydMRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response
  Staples, C. J., Barone, G., Myers, K. N., Ganesh, A., Gibbs-Seymour, I., Patil, A. A., Beveridge, R. D., Daye, C., Beniston, R., Maslen, S., Ahel, I., Skehel, J. M. & Collis, S. J., 6 Medi 2016, Yn: Cell. 16, 10, t. 2565-75 11 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydThe bornavirus-derived human protein EBLN1 promotes efficient cell cycle transit, microtubule organisation and genome stability
  Myers, K. N., Barone, G., Ganesh, A., Staples, C. J., Howard, A. E., Beveridge, R. D., Maslen, S., Skehel, J. M. & Collis, S. J., 14 Hyd 2016, Yn: Scientific Reports. 6, t. 35548
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2014

• CyhoeddwydCcdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability
  Staples, C. J., Myers, K. N., Beveridge, R. D., Patil, A. A., Howard, A. E., Barone, G., Lee, A. J., Swanton, C., Howell, M., Maslen, S., Skehel, J. M., Boutlon, S. J. & Collis, S. J., 1 Gorff 2014, Yn: Journal of Cell Science. 127, t. 2910-2919
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydThe leukemia-associated Rho guanine nucleotide exchange factor LARG is required for efficient replication stress signaling
  Beveridge, R. D., Staples, C. J., Patil, A. A., Myers, K. N., Maslen, S., Skehel, J. M., Boulton, S. J. & Collis, S. J., 29 Hyd 2014, Yn: Cell Cycle. 13, 21, t. 3450-3459
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2011

• CyhoeddwydPhosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways
  Dickinson, R. J., Delavaine, L., Cejudo-Marín, R., Stewart, G., Staples, C. J., Didmon, M. P., Trinidad, A. G., Alonso, A., Pulido, R. & Keyse, S. M., 4 Tach 2011, Yn: Journal of Biological Chemistry. 286, 44, t. 38018-26 9 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2010

• CyhoeddwydCross-talk between the p38alpha and JNK MAPK pathways mediated by MAP kinase phosphatase-1 determines cellular sensitivity to UV radiation
  Staples, C. J., Owens, D. M., Maier, J. V., Cato, A. C. B. & Keyse, S. M., 20 Awst 2010, Yn: Journal of Biological Chemistry. 285, 34, t. 25928-40 13 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2009

• CyhoeddwydRegulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK
  Kucharska, A., Rushworth, L. K., Staples, C., Morrice, N. A. & Keyse, S. M., Rhag 2009, Yn: Cellular Signalling. 21, 12, t. 1794-805 12 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2008

• CyhoeddwydNegative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter
  Ekerot, M., Stavridis, M. P., Delavaine, L., Mitchell, M. P., Staples, C., Owens, D. M., Keenan, I. D., Dickinson, R. J., Storey, K. G. & Keyse, S. M., 1 Meh 2008, Yn: Biochemical Journal. 412, 2, t. 287-98 12 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2007

• CyhoeddwydBiophysical properties of salmonid alphaviruses: influence of temperature and pH on virus survival
  Graham, D. A., Staples, C., Wilson, C. J., Jewhurst, H., Cherry, K., Gordon, A. & Rowley, H. M., Medi 2007, Yn: Journal of Fish Biology. 30, 9, t. 533-43 11 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2021

• BBSRC reviewer

  20 Meh 2021

  Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr)
• The Role of HERC2 in Ciliogenesis

  Invited talk at the 26th UK Cilia Network Symposium

  17 Mai 2021

  Gweithgaredd: Cyflwyniad llafar (Siaradwr)
• NWCR Scientific Committee Membership

  Member of scientific panel

  9 Mai 2021 →

  Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr)
• Peer reviewer for the Humane Research Trust

  9 Mai 2021

  Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr)

2020

• DNA Repair (Cyfnodolyn)

  Peer reviewer

  7 Tach 2020

  Gweithgaredd: Adolygu cyhoeddiadau cymheiriaid (Aelod o fwrdd golygyddol)
• Peer-reviewer for UKRI Future Leaders Fellowships

  Peer-reviewer for UKRI Future Leaders Fellowships

  25 Hyd 2020

  Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr)
• Molecular Oncology (Cyfnodolyn)

  Peer review

  11 Medi 2020

  Gweithgaredd: Adolygu cyhoeddiadau cymheiriaid (Aelod o fwrdd golygyddol)
• BBSRC Peer Review

  Reviewed a BBSRC Responsive Mode Application

  31 Awst 2020

  Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr)
• Internal Examiner for PhD Viva

  21 Ebr 2020

  Gweithgaredd: Arholiad (Arholwr)
• Chair for PhD Viva

  2 Ebr 2020

  Gweithgaredd: Arholiad (Arholwr)
• Peer review

  Provided peer review for a BBSRC project grant application

  4 Maw 2020

  Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr)
• PLoS Biology (Cyfnodolyn)

  Acted as peer reviewer

  7 Ion 2020

  Gweithgaredd: Adolygu cyhoeddiadau cymheiriaid (Aelod o fwrdd golygyddol)

2019

• External examiner for PhD candidate in Lancaster

  Supervised by Nikki Copeland

  13 Meh 2019

  Gweithgaredd: Arholiad (Arholwr)
• Examined Prof Ciaran Morrisons PhD student (Galway)

  External examiner

  4 Meh 2019

  Gweithgaredd: Arholiad (Arholwr)
• MRNIP is a novel replication fork protection factor

  15 min talk at international conference

  2019

  Gweithgaredd: Cyflwyniad llafar (Siaradwr)

2018

• Novel players in replication fork protection

  Invited speaker to research seminar series

  18 Maw 2018

  Gweithgaredd: Cyflwyniad llafar (Siaradwr)
• External examiner for MRes viva

  29 Ion 2018

  Gweithgaredd: Arholiad (Arholwr)

2017

• Internal Examiner for PhD viva

  9 Tach 2017

  Gweithgaredd: Arholiad (Arholwr)
• The role of MRNIP in DNA repair

  Invited speaker to research seminar series

  11 Mai 2017

  Gweithgaredd: Cyflwyniad llafar (Siaradwr)

• A novel role for the innate immune sensor IFI16 in the cancer cell response to chemotherapy

  01/01/2024 – 15/01/2026 (Heb ei ddechrau)

• Regulation of chemosensitivity by the novel daughter strand gap suppressor MRNIP

  01/12/2023 – 15/12/2026 (Heb ei ddechrau)

• Daughter Strand Gaps as determinants of chemoresistance

  01/11/2023 – 15/11/2025 (Heb ei ddechrau)

• Regulation of DNA repair and innate immune response to radio- and chemotherapy by the DNA sensors cGAS and IFI16

  01/01/2023 – 31/01/2026 (Wrthi'n gweithredu)

• Daughter strand gaps as crucial determinants of therapeutic response

  01/10/2022 – 31/10/2025 (Wrthi'n gweithredu)

• KESS II MRes with NWCR - BUK2E089

  01/10/2022 – 31/10/2023 (Wrthi'n gweithredu)

• KESS II MRes with BEE Robotics BUK2E081

  01/07/2022 – 31/10/2023 (Wrthi'n gweithredu)

• HEFCW HEIR COVID extension to UKRI FLF MRC bid (F008177, R49R01, MR/S034579/1)

  01/05/2021 – 31/08/2021 (Wedi gorffen)

• KESS II MRes with North West Cancer Research BUK2225

  01/01/2021 – 01/08/2022 (Wedi gorffen)

• KESS II East Phd with North West Cancer Research BUK2E019

  01/02/2020 – 01/09/2023 (Wedi gorffen)

• The role of MRNIP in replication fork stabilisation and DSB repair

  01/12/2019 – 31/12/2023 (Wrthi'n gweithredu)

• Potential roles of MRNIP and IFI16 in linking oncogene-induced replication

  01/07/2019 – 01/08/2022 (Wedi gorffen)

• Replication fork reversal and stability (UNS87415 Mr Anuj Narwal)

  01/06/2019 – 01/08/2019 (Wedi gorffen)

• Investigation of novel regulators of genome stability

  01/01/2019 – 30/09/2023 (Wrthi'n gweithredu)

• Autophagy dependent survival following Mec1(ATM/ATR) inactivation

  01/05/2018 – 31/07/2023 (Wedi gorffen)

• Role of RadIP, a novel DNA repair factor in the DNA damage response to chemotherapy.

  01/11/2016 – 31/08/2020 (Wedi gorffen)

• Targeting CtIP to sensitise cancer cells to DNA-damaging agents

  01/10/2016 – 31/07/2018 (Wedi gorffen)

• Therapeutically relevant novel links between DNA damage and ciliogenesis

  01/10/2016 – 19/08/2023 (Wedi gorffen)