• PhD: Regulation of MAP kinase phosphatases
  University of Dundee, 2006–2010

Teaching Credits

MSE-3016 Pathophysiology (10 credits) - Module Organiser

MSE-2025 Molecular Biology and Biochemistry (10 credits) 

MSE-3013 Third Year Research Project 

MSE-4025 Dissertation

Teaching and Supervision Roles

Undergraduate project/dissertation supervision. Supervision of PhD, MSc and MRes students.

Other roles

College representative on Research Concordat Committee

External and internal viva voce examiner

Teaching and Scholarship Awards

PGCertHE Stage 1 (2017)

PGCertHE Stage 2 (2018)

Fellow of the Higher Education Academy (HEA)

Work in the Staples laboratory focuses largely on the characterisation of novel genome stability factors. Genome instability and DNA damage are central pathogenic mechanisms involved in cancer predisposition, premature ageing and neurodegeneration. Indeed, some cancer therapies target cancer-specific defects in DNA repair or replication fork protection mechanisms, and as such a complete understanding of such mechanisms is a major asset in the fight against cancer.

We have identified several novel DNA repair and replication fork protection factors, and our aim is to gain mechanistic insight into the function of these largely unstudied proteins with the ultimate goal of using this knowledge to design novel cancer therapies and/or predict therapeutic response.

2020

• Cyhoeddwydjava.lang.NullPointerException

2017

• Cyhoeddwydjava.lang.NullPointerException

2016

• Cyhoeddwydjava.lang.NullPointerException
• Cyhoeddwydjava.lang.NullPointerException
• Cyhoeddwydjava.lang.NullPointerException

2014

• Cyhoeddwydjava.lang.NullPointerException
• Cyhoeddwydjava.lang.NullPointerException

2011

• Cyhoeddwydjava.lang.NullPointerException

2010

• Cyhoeddwydjava.lang.NullPointerException

2009

• Cyhoeddwydjava.lang.NullPointerException

2008

• Cyhoeddwydjava.lang.NullPointerException

2007

• Cyhoeddwydjava.lang.NullPointerException

2021

• BBSRC reviewer

  20 Meh 2021

  Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr)
• The Role of HERC2 in Ciliogenesis

  Invited talk at the 26th UK Cilia Network Symposium

  17 Mai 2021

  Gweithgaredd: Cyflwyniad llafar (Siaradwr)
• NWCR Scientific Committee Membership

  Member of scientific panel

  9 Mai 2021 →

  Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr)
• Peer reviewer for the Humane Research Trust

  9 Mai 2021

  Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr)

2020

• DNA Repair (Cyfnodolyn)

  Peer reviewer

  7 Tach 2020

  Gweithgaredd: Adolygu cyhoeddiadau cymheiriaid (Aelod o fwrdd golygyddol)
• Peer-reviewer for UKRI Future Leaders Fellowships

  Peer-reviewer for UKRI Future Leaders Fellowships

  25 Hyd 2020

  Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr)
• Molecular Oncology (Cyfnodolyn)

  Peer review

  11 Medi 2020

  Gweithgaredd: Adolygu cyhoeddiadau cymheiriaid (Aelod o fwrdd golygyddol)
• BBSRC Peer Review

  Reviewed a BBSRC Responsive Mode Application

  31 Awst 2020

  Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr)
• Internal Examiner for PhD Viva

  21 Ebr 2020

  Gweithgaredd: Arholiad (Arholwr)
• Chair for PhD Viva

  2 Ebr 2020

  Gweithgaredd: Arholiad (Arholwr)
• Peer review

  Provided peer review for a BBSRC project grant application

  4 Maw 2020

  Gweithgaredd: Mathau o waith ymgysylltu academaidd allanol - Cyfraniad at waith pwyllgorau a gweithgorau cenedlaethol neu ryngwladol (Cyfrannwr)
• PLoS Biology (Cyfnodolyn)

  Acted as peer reviewer

  7 Ion 2020

  Gweithgaredd: Adolygu cyhoeddiadau cymheiriaid (Aelod o fwrdd golygyddol)

2019

• External examiner for PhD candidate in Lancaster

  Supervised by Nikki Copeland

  13 Meh 2019

  Gweithgaredd: Arholiad (Arholwr)
• Examined Prof Ciaran Morrisons PhD student (Galway)

  External examiner

  4 Meh 2019

  Gweithgaredd: Arholiad (Arholwr)
• MRNIP is a novel replication fork protection factor

  15 min talk at international conference

  2019

  Gweithgaredd: Cyflwyniad llafar (Siaradwr)

2018

• Novel players in replication fork protection

  Invited speaker to research seminar series

  18 Maw 2018

  Gweithgaredd: Cyflwyniad llafar (Siaradwr)
• External examiner for MRes viva

  29 Ion 2018

  Gweithgaredd: Arholiad (Arholwr)

2017

• Internal Examiner for PhD viva

  9 Tach 2017

  Gweithgaredd: Arholiad (Arholwr)
• The role of MRNIP in DNA repair

  Invited speaker to research seminar series

  11 Mai 2017

  Gweithgaredd: Cyflwyniad llafar (Siaradwr)

• Daughter strand gaps as crucial determinants of therapeutic response

  01/10/2022 – 31/10/2025 (Wrthi'n gweithredu)

• KESS II MRes with NWCR - BUK2E089

  01/10/2022 – 31/10/2023 (Wrthi'n gweithredu)

• KESS II MRes with BEE Robotics BUK2E081

  01/07/2022 – 31/10/2023 (Wrthi'n gweithredu)

• HEFCW HEIR COVID extension to UKRI FLF MRC bid (F008177, R49R01, MR/S034579/1)

  01/05/2021 – 31/08/2021 (Wedi gorffen)

• KESS II MRes with North West Cancer Research BUK2225

  01/01/2021 – 30/11/2022 (Wedi gorffen)

• KESS II East Phd with North West Cancer Research BUK2E019

  01/02/2020 – 31/07/2023 (Wrthi'n gweithredu)

• The role of MRNIP in replication fork stabilisation and DSB repair

  01/12/2019 – 31/12/2023 (Wrthi'n gweithredu)

• Potential roles of MRNIP and IFI16 in linking oncogene-induced replication

  01/07/2019 – 21/09/2022 (Wedi gorffen)

• Replication fork reversal and stability (UNS87415 Mr Anuj Narwal)

  01/06/2019 – 01/08/2019 (Wedi gorffen)

• Investigation of novel regulators of genome stability

  01/01/2019 – 28/02/2023 (Wedi gorffen)

• Autophagy dependent survival following Mec1(ATM/ATR) inactivation

  01/05/2018 – 31/07/2023 (Wrthi'n gweithredu)

• Role of RadIP, a novel DNA repair factor in the DNA damage response to chemotherapy.

  01/11/2016 – 31/08/2020 (Wedi gorffen)

• Targeting CtIP to sensitise cancer cells to DNA-damaging agents

  01/10/2016 – 31/07/2018 (Wedi gorffen)

• Therapeutically relevant novel links between DNA damage and ciliogenesis

  01/10/2016 – 04/02/2023 (Wedi gorffen)