2023

• CyhoeddwydSelective Killing of BRCA2-Deficient Ovarian Cancer Cells via MRE11 Blockade
  Alblihy , A., Ali , R., Algethami, M., Ritchie, A. A., Shoqafi, A., Alqahtani, S., Mesquita, K. A., Toss, M. S., Ordóñez-Morán , P., Jeyapalan, J. N., Dekker , L., Salerno, M., Hartsuiker, E., Grabowska , A. M., Rakha, E. A., Mongan, N. P. & Madhusudan, S., 30 Meh 2023, Yn: International journal of molecular sciences. 24, 13
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2020

• CyhoeddwydData presenting the synthesis of three novel stimuli responsive hyperbranched polymers synthesised via RAFT polymerisation and the bio conjugation of folic acid
  Blackburn, C., Tai, H., Salerno, M., Wang, X., Senan, C., Ratcliffe, I., Hartsuiker, E. & Wang, W., Chwef 2020, Yn: Data in Brief. 28, 104861.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydMre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication
  Böckemeier, L., Kraehenbuehl, R., Keszthelyi, A., Gasasira, M. U., Vernon, E., Beardmore, R., Broberg Vågbø, C., Chaplin, D., Collins, S., Krokan, H. E., Lambert, S. A. E., Paisz, B. & Hartsuiker, E., 29 Mai 2020, Yn: Science Advances. 6, 22, 9 t., eaaz4126.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2019

• CyhoeddwydFolic acid and rhodamine labelled pH responsive hyperbranched polymers: Synthesis, characterization and cell uptake studies
  Blackburn, C., Tai, H., Salerno, M., Wang, X., Hartsuiker, E. & Wang, W., Tach 2019, Yn: European Polymer Journal. 120, 109259.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2018

• CyhoeddwydGenetic Interaction Score (S-Score) Calculation, Clustering, and Visualization of Genetic Interaction Profiles for Yeast.
  Roguev, A., Ryan, C. J., Xu, J., Colson, I., Hartsuiker, E. & Krogan, N., Chwef 2018, Yn: Cold Spring Harbor Protocols. 2018, 2
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydGenetic Interaction Screens in Schizosaccharomyces pombe Using the Pombe Epistasis Mapper (PEM) System and a Manual Colony Replicator.
  Colson, I. & Hartsuiker, E., Chwef 2018, Yn: Cold Spring Harbor Protocols. 2018, 2
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydHigh-Throughput Quantitative Genetic Interaction Mapping in the Fission Yeast Schizosaccharomyces pombe.
  Roguev, A., Ryan, C. J., Hartsuiker, E. & Krogan, N. J., Chwef 2018, Yn: Cold Spring Harbor Protocols. 2018, 2, t. 75-81 7 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2017

• CyhoeddwydDeoxynucleoside Salvage in Fission Yeast Allows Rescue of Ribonucleotide Reductase Deficiency but Not Spd1-Mediated Inhibition of Replication
  Fleck, O., Fahnøe, U., Løvschal, K. V., Gasasira Uwamahoro, M.-F., Marinova, I. N., Kragelund, B. B., Carr, A. M., Hartsuiker, E., Holmberg, C. & Nielsen, O., 25 Ebr 2017, Yn: Genes. 8, 5, 14 t., 128.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2015

• CyhoeddwydThe DNA-Binding Domain of S-pombe Mrc1 (Claspin) Acts to Enhance Stalling at Replication Barriers
  Zech, J., Godfrey, E. L., Masai, H., Hartsuiker, E. & Dalgaard, J. Z., 22 Gorff 2015, Yn: PLoS ONE. 10, 7
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydUV induced ubiquitination of the yeast Rad4-Rad23 complex promotes survival by regulating cellular dNTP pools
  Zhou, Z., Humphryes, N., van Eijk, P., Waters, R., Yu, S. R., Kraehenbuehl, R., Hartsuiker, E. & Reed, S. H., 6 Gorff 2015, Yn: Nucleic Acids Research. 43, 15, t. 7360-7370
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2011

• CyhoeddwydDetection of covalent DNA-bound Spo11 and topoisomerase complexes
  Hartsuiker, E. & Tsubouchi, H. (Golygydd), 28 Ebr 2011, DNA recombination: Methods and Protocols. Springer Science and Business Media LLC, t. 65-77
  Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion Cynhadledd › Pennod

2010

• CyhoeddwydCollaborative Action of Brca1 and CtIP in Elimination of Covalent Modifications from Double-Strand Breaks to Facilitate Subsequent Break Repair
  Nakamura, K., Kogame, T., Oshiumi, H., Shinohara, A., Sumitomo, Y., Agama, K., Pommier, Y., Tsutsui, K. M., Tsutsui, K., Hartsuiker, E., Ogi, T., Takeda, S. & Taniguchi, Y., 22 Ion 2010, Yn: PLOS Genetics. 6, 1
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydTopoisomerase I regulates open chromatin and controls gene expression in vivo
  Durand-Dubief, M., Persson, J., Norman, U., Hartsuiker, E. & Ekwall K., [. V., 7 Gorff 2010, Yn: EMBO Journal. 29, 13, t. 2126 - 2134
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2009

• CyhoeddwydA supramodular FHA/BRCT-Repeat architecture mediates Nbs1 adaptor function in response to DNA damage.
  Lloyd, J., Chapman, J. R., Clapperton, J. A., Haire, L. F., Hartsuiker, E., Li, J., Carr, A. M., Jackson, S. P. & Smerdon, S. J., 2 Hyd 2009, Yn: Cell. 139, 1, t. 100-111
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydCtp1CtIP and Rad32Mre11 nuclease activity are required for Rec12Spo11 removal, but Rec12Spo11 removal is dispensable for other MRN-dependent meiotic functions
  Hartsuiker, E., Mizuno, K., Molnar, M., Kohli, J., Ohta, K. & Carr, A. M., Ebr 2009, Yn: Molecular and Cellular Biology. 29, 7, t. 1671-1681 11 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydDistinct Requirements for the Rad32Mre11 Nuclease and Ctp1CtIP in the Removal of Covalently Bound Topoisomerase I and II from DNA
  Hartsuiker, E., Neale, M. J. & Carr, A. M., 16 Ion 2009, Yn: Molecular Cell. 33, 1, t. 117-123
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydScreening a genome-wide S.pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.
  Deshpande, G. P., Hayles, J., Hoe, K. L., Kim, D. U., Park, H. O. & Hartsuiker, E., 1 Mai 2009, Yn: DNA Repair. 8, 5, t. 672-679
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2007

• CyhoeddwydTDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks
  El-Khamisy, S. F., Hartsuiker, E. & Caldecott, K. W., 1 Hyd 2007, Yn: DNA Repair. 6, 10, t. 1485-95 11 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2006

• CyhoeddwydDouble-strand break repair and homologous recombination in Schizosaccharomyces pombe
  Raji, H. & Hartsuiker, E., 15 Hyd 2006, Yn: Yeast. 23, 13, t. 963-76 14 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2005

• CyhoeddwydThe meiotic recombination hot spot ura4A in Schizosaccharomyces pombe
  Baur, M., Hartsuiker, E., Lehmann, E., Ludin, K., Munz, P. & Kohli, J., Chwef 2005, Yn: Genetics. 169, 2, t. 551-61 11 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2004

• CyhoeddwydRoles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot
  Yamada, T., Mizuno, K.-I., Hirota, K., Kon, N., Wahls, W. P., Hartsuiker, E., Murofushi, H., Shibata, T. & Ohta, K., 21 Ebr 2004, Yn: EMBO Journal. 23, 8, t. 1792-803 12 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2003

• CyhoeddwydA simple Cre-loxP method for chromosomal N-terminal tagging of essential and non-essential Schizosaccharomyces pombe genes
  Werler, P. J. H., Hartsuiker, E. & Carr, A. M., 30 Ion 2003, Yn: Gene. 304, t. 133-41 9 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2002

• CyhoeddwydA 160-bp palindrome is a Rad50.Rad32-dependent mitotic recombination hotspot in Schizosaccharomyces pombe
  Farah, J. A., Hartsuiker, E., Mizuno, K.-I., Ohta, K. & Smith, G. R., Mai 2002, Yn: Genetics. 161, 1, t. 461-8 8 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydA single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway
  Marchetti, M. A., Kumar, S., Hartsuiker, E., Maftahi, M., Carr, A. M., Freyer, G. A., Burhans, W. C. & Huberman, J. A., 28 Mai 2002, Yn: Proceedings of the National Academy of Sciences of the United States of America. 99, 11, t. 7472-7 6 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2001

• CyhoeddwydFission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repair
  Hartsuiker, E., Vaessen, E., Carr, A. M. & Kohli, J., 3 Rhag 2001, Yn: EMBO Journal. 20, 23, t. 6660-71 12 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
• CyhoeddwydNovel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe
  Manolis, K. G., Nimmo, E. R., Hartsuiker, E., Carr, A. M., Jeggo, P. A. & Allshire, R. C., 15 Ion 2001, Yn: EMBO Journal. 20, 1-2, t. 210-21 12 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

1999

• CyhoeddwydThe msh2 gene of Schizosaccharomyces pombe is involved in mismatch repair, mating-type switching, and meiotic chromosome organization
  Rudolph, C., Kunz, C., Parisi, S., Lehmann, E., Hartsuiker, E., Fartmann, B., Kramer, W., Kohli, J. & Fleck, O., Ion 1999, Yn: Molecular and Cellular Biology. 19, 1, t. 241-50 10 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

1998

• CyhoeddwydThe role of topoisomerase II in meiotic chromosome condensation and segregation in Schizosaccharomyces pombe
  Hartsuiker, E., Bähler, J. & Kohli, J., Hyd 1998, Yn: Molecular Biology of the Cell. 9, 10, t. 2739-50 12 t.
  Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

1994

• CyhoeddwydImmunocytochemical techniques applied to meiotic chromosomes
  Heyting, C., Dietrich, A. J., de Jong, J. H. & Hartsuiker, E., 1994, Chromosome Analysis Protocols. Gosden, J. R. (gol.). Cyfrol 29. t. 287-302 (Methods in Molecular Biology).
  Allbwn ymchwil: Pennod mewn Llyfr/Adroddiad/Trafodion Cynhadledd › Pennod › adolygiad gan gymheiriaid

2022

• BU-IIA Funded Project: Genotoxicity of nucleoside analogue anti-viral and anti-cancer drugs

  The overall aim of the proposed research is to optimise and apply the range of assays we have developed to assess the genotoxic impact of some key anti-cancer (Gemcitabine) and anti-viral (Remdesivir and Molnupiravir) nucleoside analogues and publish this analysis as proof of principle and advertise the knowledge and expertise we have developed here in Wales. The proposed research involves a new collaboration between Bangor applicants and the recently established company Broken String Biosciences Ltd., which offers assays that are complementary to the assays we have been developing. In the long term, we believe there is significant potential for impact and commercial exploitation of our assays, e.g. by influencing requirements for genotoxic assessment of nucleoside analogue drugs and offering our expertise and novel assays as a commercial service for pharmaceutical companies to assess the on- and off-target effects of candidate nucleoside analogue drugs.

  Funding awarded through the Bangor University Innovation and Impact Award (Research Wales Innovation Funding). Value = £45,942

  1 Ebr 2022 – 31 Maw 2023

  Gweithgaredd: Arall (Cyfrannwr)

• Exploiting synthetic lethality for cancer treatment: improving the activity and specificity of novel MRE11 inhibitors

  01/10/2025 – 15/10/2028 (Heb ei ddechrau)

• Skills & Innovation voucher scheme - Beerobotics - Maxi

  01/05/2024 – 30/04/2025 (Wedi gorffen)

• KESS II MRes with NWCR - BUK2E091

  01/10/2022 – 31/03/2024 (Wedi gorffen)

• KESS II Mres with NWCR in Molecular Medicine BUK2231

  01/10/2022 – 31/03/2024 (Wedi gorffen)

• KESS II MRes with North West Cancer Research BUK2222

  01/01/2021 – 31/01/2022 (Wedi gorffen)

• KESS II MRes with North West Cancer Research BUK2224

  01/01/2021 – 31/03/2024 (Wedi gorffen)

• KESS II Phd with Tenovus BUK2E004

  01/03/2020 – 31/03/2024 (Wedi gorffen)

• KESS II MRes with North West Cancer Research- BUK2176

  01/10/2019 – 31/03/2024 (Wedi gorffen)

• KESS II MRes with North West Cancer Research- BUK2175

  01/10/2018 – 01/08/2022 (Wedi gorffen)

• KESS II MRes with North West Cancer Research- BUK2177

  01/10/2018 – 31/03/2024 (Wedi gorffen)

• KESS II MRes with North West Cancer Research- BUK2178

  01/10/2018 – 31/03/2024 (Wedi gorffen)

• KESS II Phd with Tenovus Cancer Care Ltd- BUK2128

  01/11/2017 – 31/03/2024 (Wedi gorffen)

• Quantitative detection of DNA damage and nucleotides using LC/MS/MS

  01/01/2016 – 30/04/2016 (Wedi gorffen)

• Genome-wide analysis of topoisomerase removal pathways

  01/09/2015 – 01/08/2019 (Wedi gorffen)

• Wales Cancer Research Centre

  01/04/2015 – 01/08/2019 (Wedi gorffen)

• Funding for equipment

  01/01/2015 – 30/09/2023 (Wedi gorffen)

• Role of Mre11 nuclease activity in replication fork progression

  01/11/2014 – 31/10/2015 (Wedi gorffen)

• Role of DNA repair in resisting treatment with Gemcitabine and other analogues

  01/01/2014 – 30/06/2017 (Wedi gorffen)

• NWCR Research Fellow in Cancer Biology

  23/09/2013 – 01/08/2019 (Wedi gorffen)

• The role of nucleotide excision repair in providing resistance to the nucleoside

  01/06/2013 – 10/11/2017 (Wedi gorffen)

• The role of the Mre11 nuclease activity in resistance to cancer drugs

  01/12/2011 – 30/11/2013 (Wedi gorffen)

• Genome-wide analysis of topoisomerase removal after camptothecin treatment

  01/10/2011 – 31/12/2014 (Wedi gorffen)

• The NISCHR Cancer Genetics Biomedical Research Unit

  01/03/2011 – 01/08/2022 (Wedi gorffen)

• Identification and analysis of DNA repair mechanisms that contribute to resistance against nucleoside analogues

  01/10/2010 – 30/09/2014 (Wedi gorffen)

• Analysis of MRN-dependent and -independent topoisomerase removal mechanisms: implications for resistance against camptothecin and etoposide derivatives

  01/09/2010 – 31/08/2016 (Wedi gorffen)