Dr Emily Holmes

• Understanding medication adherence: application of health psychology & behavioural economic theories PhD
• Health Economics and Health Policy MSc (University of Birmingham)
• Economics BA (University of Liverpool)

Emily’s research interests and expertise include preference elicitation, medication adherence, and pharmacoeconomic evaluation.  She is Principal Investigator of studies evaluating: treatment preferences, medicines management in prison, antimicrobial prescribing, and attitudes towards epilepsy.  She is co-investigator on a study of emergency care following seizures (Collaborate), and she supports several projects in CHEME aligned to her interests of medication adherence (SuMMiT-D), preferences for medicines administration/outcomes (CARiAD), and neurology (EN-PNS, SAFE). 

Emily graduated in Economics at the University of Liverpool and started her career at the University of Manchester, before taking her position at Bangor University.  She completed her doctoral research in behavioural economics and health psychology of medication adherence.    Emily has over 40 published papers and conference proceedings, she edits health technology assessment reports for the All Wales Therapeutics and Toxicology Centre (AWTTC), and is a member of the Epilepsy Action Scientific Awards Panel and the Bangor University Athena SWAN task group.

PhD Supervision:

Nafees Din.  Androgens - CHOice of Intermittent vs Continual– Prostate Cancer (A CHOICe-PC), funded by Tenovus Cancer Care.   PhD Health Sciences, Bangor University.

Short Course Teaching:

Pharmacoeconomics short course, Bangor University. 

Online Course Contributor :

European Society for Patient Adherence, Compliance and Persistence (ESPACOMP) educational course.

Principal Investigator:

Patient centred benefit-risk assessment of treatment for colorectal liver metastases in North West England and North Wales (NWCR).

Modelling the health economic outcomes of ‘medicines management of sedating medications’ at HMP Berwyn. A feasibility study (BCUHB).

Developing a protocol and conducting an appropriately powered random-stratified sample of the UK population, to measure changing public attitudes to epilepsy and people with epilepsy (Epilepsy Action).

Cost effectiveness analysis of the use of C reactive protein point of care tests in primary care; a model based on the North Wales pilot project (BCUHB).

Co-investigator:

Developing patient-centred, feasible alternative care for emergency department users with epilepsy. A model for service design (NIHR).

Appointed Research Fellow for Health Economics:

A randomised patient-assessor blinded controlled trial of External non-invasive peripheral nerve stimulation for chronic neuropathic pain following peripheral nerve injury (EN-PENS).

A follow-on study to develop and pilot ‘Seizure first Aid training For Epilepsy’ (SAFE) for people with epilepsy who attend emergency departments, and their family and friends.

Supporting people with type 2 diabetes in effective use of their medicine through a system comprising mobile health technology integrate with clinical care (SUMMiT-D).

CARer-ADministration of as-needed sub-cutaneous medication for breakthrough symptoms in homebased dying patients: a UK study (CARiAD).

2019

• What really matters?
  
  Ring, A, Jacoby, A, Baker, GA, Holmes, E, Hughes, D, Kierans, C & Marson, A 2019, 'What really matters? A mixed methods study of treatment preferences and priorities among people with epilepsy in the UK', Epilepsy and Behavior.
• CARer-ADministration of as-needed subcutaneous medication for breakthrough symptoms in homebased dying patients (CARiAD)
  
  Poolman, M, Roberts, J, Byrne, A, Perkins, P, Hoare, Z, Nelson, A, Hiscock, J, Hughes, D, Foster, B, O'Connor, J, Reymond, L, Healy, S, Roberts, R, Wee, B, Lewis, P, Johnstone, R, Roberts, S, Holmes, E, Wright, S, Hendry, A & Wilkinson, C 2019, 'CARer-ADministration of as-needed subcutaneous medication for breakthrough symptoms in homebased dying patients (CARiAD): study protocol for a UK-based open randomised pilot trial', Trials, vol. 20, 105. https://doi.org/10.1186/s13063-019-3179-9
• Attitudes towards epilepsy in the UK population
  
  Holmes, E, Bourke, S & Plumpton, C 2019, 'Attitudes towards epilepsy in the UK population: Results from a 2018 national survey', Seizure: European Journal of Epilepsy, vol. 65, pp. 12-19. https://doi.org/10.1016/j.seizure.2018.12.012

2018

• People with dementia and caregiver preferences for digital life story work service interventions
  
  O' Philbin, L, Woods, R & Holmes, E 2018, 'People with dementia and caregiver preferences for digital life story work service interventions: A discrete choice experiment and digital survey', Aging and Mental Health. https://doi.org/10.1080/13607863.2018.1525606
• Cost-Effectiveness Analysis of the Use of Point-of-Care C-Reactive Protein Testing to Reduce Antibiotic Prescribing in Primary Care
  
  Holmes, E, Harris, SD, Hughes, A, Craine, N & Hughes, D 2018, 'Cost-Effectiveness Analysis of the Use of Point-of-Care C-Reactive Protein Testing to Reduce Antibiotic Prescribing in Primary Care', Antibiotics, vol. 7, no. 4, 106. https://doi.org/10.3390/antibiotics7040106
• Patient-focused drug development methods for benefit-risk assessments
  
  Holmes, E, Plumpton, C, Baker, GA, Jacoby, A, Ring, A, Williamson, P, Marson, A & Hughes, D 2018, 'Patient-focused drug development methods for benefit-risk assessments: A case study using discrete choice experiment for antiepileptic drugs', Clinical Pharmacology and Therapeutics. https://doi.org/10.1002/cpt.1231

2017

• Patient preferences for outcomes in clinical trials: implications for medicines optimization
  
  Holmes, E, Marson, AG & Hughes, D 2017, 'Patient preferences for outcomes in clinical trials: implications for medicines optimization', Trials, vol. 18 (Suppl 1), no. O18, pp. 192. https://doi.org/10.1186/s13063-017-1902-y

2016

• A randomised, patient-assessor blinded, sham-controlled trial of external noninvasive peripheral nerve stimulation for chronic neuropathic pain following peripheral nerve injury (EN-PENS trial)
  
  Johnson, S, Goebel, A, Richey, R, Holmes, E & Hughes, D 2016, 'A randomised, patient-assessor blinded, sham-controlled trial of external noninvasive peripheral nerve stimulation for chronic neuropathic pain following peripheral nerve injury (EN-PENS trial): study protocol for a randomised controlled trial', Trials, vol. 17, 574. https://doi.org/10.1186/s13063-016-1709-2
• What influences persistence with medicines? A multinational discrete choice experiment of 2549 patients
  
  Holmes, EA, Morrison, VL & Hughes, D 2016, 'What influences persistence with medicines? A multinational discrete choice experiment of 2549 patients', British Journal of Clinical Pharmacology, vol. 82, no. 2, pp. 522-531. https://doi.org/10.1111/bcp.12971
• Conducting Economic Evaluations Alongside Randomised Trials: Current Methodological Issues and Novel Approaches
  
  Hughes, D, Charles, JM, Dawoud, DM, Edwards, RT, Holmes, EA, Jones, CL, Parham, P, Plumpton, C, Ridyard, CO, Lloyd-Williams, H, Wood, EM & Yeo, S 2016, 'Conducting Economic Evaluations Alongside Randomised Trials: Current Methodological Issues and Novel Approaches', Pharmacoeconomics, vol. 34, no. 5, pp. 447-461. https://doi.org/10.1007/s40273-015-0371-y

2015

• Pharmacogenetic testing prior to carbamazepine treatment of epilepsy: 1 patients’ and physicians’ preferences for testing and service delivery
  
  Powell, G, Holmes, EA, Plumpton, CO, Ring, A, Baker, GA, Jacoby, A, Pirmohamed, M, Marson, AG & Hughes, DA 2015, 'Pharmacogenetic testing prior to carbamazepine treatment of epilepsy: 1 patients’ and physicians’ preferences for testing and service delivery', British Journal of Clinical Pharmacology. https://doi.org/10.1111/bcp.12715
• Adherence of patients to long-term medication
  
  Lotsch, F, Auer-Hackenberg, L, Groger, M, Rehman, K, Morrison, VL, Holmes, EA, Parveen, S, Plumpton, CO, Clyne, W, de Geest, S, Dobbels, F, Vrijens, B, Kardas, P, Hughes, D & Ramharter, M 2015, 'Adherence of patients to long-term medication: a cross-sectional study of antihypertensive regimens in Austria', Wiener klinische Wochenschrift, vol. 127, no. 9-10, pp. 379-384. https://doi.org/1007/s00508-015-0782-y
• Predictors of Self-Reported Adherence to Antihypertensive Medicines
  
  Morrison, VL, Holmes, EA, Parveen, S, Plumpton, CO, Clyne, W, De Geest, S, Dobbels, F, Vrijens, B, Kardas, P & Hughes, D 2015, 'Predictors of Self-Reported Adherence to Antihypertensive Medicines: A Multinational, Cross-Sectional Survey', Value in Health, vol. 18, no. 2, pp. 206-216. https://doi.org/10.1016/j.jval.2014.12.013

2014

• Predicting Adherence to Medications Using Health Psychology Theories: A Systematic Review of 20 Years of Empirical Research
  
  Holmes, EA, Morrison, VL & Hughes, D 2014, 'Predicting Adherence to Medications Using Health Psychology Theories: A Systematic Review of 20 Years of Empirical Research', Value in Health, vol. 17, no. 8, pp. 863-876. https://doi.org/10.1016/j.jval.2014.08.2671
• Investigating preferences for support with life after stroke: a discreet choice experiment
  
  Holmes, EA, Plumpton, CO, Roberts, GW, Burton, CR, Farghrer, E, Plumpton, C, Roberts, G, Owen, H & Roberts, E 2014, 'Investigating preferences for support with life after stroke: a discreet choice experiment', BMC Health Services Research, vol. 14, no. 63, pp. 1-13. https://doi.org/10.1186/1472-6963-14-63

2013

• New advice on switching antiepileptic drugs might be a false economy
  
  Holmes, EA, Plumpton, CO, Hughes, D, Holmes, E, Plumpton, C, Duerden, M, Marson, T & Hughes, DA 2013, 'New advice on switching antiepileptic drugs might be a false economy', British Medical Journal, vol. 347. https://doi.org/10.1136/bmj.f7471
• Identification and Assessment of Adherence-Enhancing Interventions in Studies Assessing Medication Adherence Through Electronically Compiled Drug Dosing Histories: A Systematic Literature Review and Meta-Analysis
  
  Hughes, D, Holmes, EA, Demonceau, J, Ruppar, T, Kristano, P, Hughes, AD, Fargher, E, Przemyslaw, K, De Geest, S, Dobbels, F, Lewek, P, Urquhart, J & Vrijens, B 2013, 'Identification and Assessment of Adherence-Enhancing Interventions in Studies Assessing Medication Adherence Through Electronically Compiled Drug Dosing Histories: A Systematic Literature Review and Meta-Analysis', Drugs, vol. 73, no. 6, pp. 545-562. https://doi.org/10.1007/s40265-013-0041-3

2012

• Preferences of people with diabetes for diabetic retinopathy screening: a discrete choice experiment
  
  Holmes, EA, Yeo, ST, Edwards, RT, Fargher, EA, Luzio, SD, Thomas, RL & Owens, DR 2012, 'Preferences of people with diabetes for diabetic retinopathy screening: a discrete choice experiment', Diabetic Medicine, vol. 29, no. 7, pp. 869-877. https://doi.org/10.1111/j.1464-5491.2012.03636.x
• A new taxonomy for describing and defining adherence to medications
  
  Holmes, EA, Hughes, D, Morrison, VL, Vrijens, B, De Geest, S, Hughes, DA, Prezemyslaw, K, Demonceau, J, Ruppar, T, Dobbels, F, Fargher, E, Morrison, V, Lewek, P, Matyjaszczyk, M, Mshelia, C, Clyne, W, Aronson, JK & Urquhart, J 2012, 'A new taxonomy for describing and defining adherence to medications', British Journal of Clinical Pharmocology, vol. 73, no. 5, pp. 691-705. https://doi.org/10.1111/j.1365-2125.2012.04167.x

2011

• A Pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: the TARGET study.
  
  Newman, W, Payne, K, Tricker, K, Roberts, S, Fargher, E, Pushpakom, S, Alder, JE, Sidgwick, GP, Payne, D, Elliott, RA, Heise, M, Elles, R, Ramsden, SC, Andrews, J, Houston, B, Qasim, F, Shaffer, J, Griffiths, CE, Ray, DW, Bruce, I & Ollier, WE 2011, 'A Pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: the TARGET study.', Pharmacogenomics, vol. 12, no. 6, pp. 815-826. https://doi.org/doi:10.2217/pgs.11.32
• Involving colleagues can be challenging
  
  Fargher , E & Hughes, D 2011, 'Involving colleagues can be challenging', Pharmaceutical Journal, vol. 286, pp. 404.
• Valuing pharmacogenetic testing services: A comparison of patients' and health care professionals' preferences
  
  Holmes, EA, Payne, K, Fargher, EA, Roberts, S, Tricker, K, Elliott, RA, Ratcliffe, J & Newman, W 2011, 'Valuing pharmacogenetic testing services: A comparison of patients' and health care professionals' preferences', Value in Health, vol. 14, no. 1, pp. 121-134. https://doi.org/10.1016/j.jval.2010.10.007

2010

• Women's experience of commercial weight-loss programmes
  
  Holmes, EA, Wickett, H & Fargher, EA 2010, 'Women's experience of commercial weight-loss programmes', Practice Nursing, vol. 21, no. 10, pp. 252-259.

2007

• Is shared care with annual hospital review better value for money than predominantly hospital-based care in patients with established stable rheumatoid arthritis?
  
  Holmes, EA, Davies, LM, Fargher, EA, Tricker, K, Dawes, P, Scott, DL & Symmons, D 2007, 'Is shared care with annual hospital review better value for money than predominantly hospital-based care in patients with established stable rheumatoid arthritis?', Annals of the Rheumatic Diseases, vol. 66, no. 5, pp. 658-663. https://doi.org/10.1136/ard.2006.061234
• TPMT testing in rheumatology: any better than routine monitoring?
  
  Holmes, EA, Payne, K, Newman, W, Fargher, EA, Tricker, K, Bruce, IN & Ollier, WE 2007, 'TPMT testing in rheumatology: any better than routine monitoring?', Rheumatology, vol. 46, no. 5, pp. 727-729. https://doi.org/10.1093/rheumatology/kel427
• Current use of pharmacogenetic testing: a national survey of thiopurine methyltransferase testing prior to azathioprine prescription.
  
  Holmes, EA, Fargher, EA, Tricker, K, Newman, W, Elliott, R, Roberts, SA, Shaffer, JL, Bruce, I & Payne, K 2007, 'Current use of pharmacogenetic testing: a national survey of thiopurine methyltransferase testing prior to azathioprine prescription.', Journal of Clinical Pharmacy and Therapeutics, vol. 32, no. 2, pp. 187-195. https://doi.org/10.1111/j.1365-2710.2007.00805.x

2006

• Patients' and healthcare professionals' views on pharmacogenetic testing and its future delivery in the NHS.
  
  Holmes, EA, Fargher, EA, Eddy, C, Newman, W, Qasim, F, Tricker, K, Elliott, RA & Payne, K 2006, 'Patients' and healthcare professionals' views on pharmacogenetic testing and its future delivery in the NHS.', Pharmacogenomics, vol. 8, no. 11, pp. 1511-1519. https://doi.org/10.2217/14622416.8.11.1511

2005

• Research Governance
  
  Payne, K, Fargher, E, Tricker, K, Newman, W, Qasim, F, Poulton, K, Andrews, J, Houston, JB, Elliott, RA, Elles, R, Ray, DW, Shaffer, J, Griffiths, C, Bruce, I, Roberts, SA & Ollier, WE 2005, 'Research Governance: What is reasonable protection?', BMJ, vol. 330, pp. 847.

• Cost-effectiveness analysis of the use of C reactive protein point of care tests in primary care
• Developing a protocol and conducting a sample of the UK population, to measure changing public attitudes to epilepsy and people with epilepsy
• Modelling the health economic outcomes of ‘medicines management of sedating medications’ at HMP Berwyn. A feasibility study
• Patient centred benefit-risk assessment of treatment for colorectal liver metastases in North West England and North Wales

Member of Bangor University Athena SWAN Task Group

Member of Epilepsy Action Scientific Awards Panel

NIHR and HCRW Reviewer

Epilepsy Action Local Services Volunteer