Dr Anita Malhotra

Uwch Ddarlithydd

Gwelwch proffil Dr Anita Malhotra ar Bortal Ymchwil Bangor

Gwybodaeth Cyswllt

My research interests focus on the role of natural selection in population adaptation and divergence, to which I apply a wide range of methods including multivariate morphometrics, statistical hypothesis-testing, innovative field experiments and genome analysis. I have two main areas of research on disparate organisms in different geographical regions (Anolis lizards in the Caribbean and Asian pit vipers), which are unified by being essentially focussed on the interface between evolution and ecology, and with an emphasis on the integration of genetic and phenetic data. More recently, my research has moved into the field of ecological and evolutionary genomics to evaluate the evolution of genes affecting complex traits directly and relies on the availability of a well-supported and complete organismal phylogeny of Asian pitvipers generated by my students and myself. Drawing on numerous collaborations to bring together disparate strands of organismal biology and ecology, evolutionary theory, comparative genomics, bioinformatics and proteomics, I aim to develop an integrated picture of the evolution of snake venom components.

Another strand to this research on venomous snakes involves snakebite mitigation, and I am currently involved in several projects in India, dubbed the "snakebite capital of the world", where c. 50,000 people die from snakebite every year and many more suffer permanent disability. Together with partners in India, our work ranges from mapping the distribution and genetic and venom variation present in venomous species across the country, to undertaking rescuer training and education and awareness programs. We are particularly focussing on the Himalayan and northeastern region, which belong to biodiversity "hotspots" but are relatively understudied. The venomous species in these regions are diferent to the rest of the country, and are not covered by the currently available polyvalent antivenom.

I am also involved in research on the genetic health of honeybees and other pollinators, together with colleague Dr Paul Cross. We are part of the recently formed research network on British dark bee conservation that includes researchers from Plymouth University, National University of Ireland (Galway), and the University of Edinburgh.

Cymwysterau

PhD: What causes geographic variation? A case study of Anolis oculatus
University of Aberdeen, 1988–1992
Zoology (with supplementary Anthropology)
Oxford University, 1985–1988

Cyfleoedd Project Ôl-radd

Investigation of the functional genomic basis of environmental niche adaptation Venom evolution: understanding the origin and evolution of venoms; evolutionary drivers of venom composition and underlying genetic mechanisms, relevance to snakebite treatment Speciation, natural selection, phylogeny, hybridization and other aspects of evolution in squamates, particularly island lizards, including both natural and invasive species Biogeography and systematics of venomous snakes and other reptiles, species delimitation Invasion genetics Honeybee health and population genetics

Cyhoeddiadau

2021

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2019

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CyhoeddwydPrevention is better than cure : snakebite education in India
Trogridou, A., Graham, S., Santra, V., Owens, J. B., Bharti, O. & Malhotra, A., 2019, Yn: Episthmes Agogis . t. 75-96
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

2018

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2015

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2013

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2011

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2010

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2009

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2008

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2006

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2005

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2004

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2003

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2002

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2001

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2000

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Gweithgareddau

2018

American Society of Tropical Medicine and Hygiene, Miami, USA
Poster presented as part of Global Snakebite Initiative stand
Tach 2018
Gweithgaredd: Cymryd rhan mewn cynhadledd (Cyfranogwr)
Round Table on Snakebite
7 Awst 2018
Gweithgaredd: Cymryd rhan mewn gweithdy, seminar, cwrs (Siaradwr)

2017

SNAKEBITE MITIGATION AND INNOVATIVE WAYS TO DEVELOP EFFECTIVE ANTIVENOM
Discussion workshop with the objective of reviewing the current situation around underpinning research, clinical management, antivenom manufacturing, epidemiology and education/awareness, and identifying an action-oriented plan for mitigation of snakebite
Rhag 2017
Gweithgaredd: Cymryd rhan mewn gweithdy, seminar, cwrs (Trefnydd)

2015

Toxins (Cyfnodolyn)
Editorial Board member
2015 →
Cysylltau:
- http://www.mdpi.com/journal/toxins/editors#EB_animal-venoms
Gweithgaredd: Gweithgarwch golygyddol (Aelod o fwrdd golygyddol)

Projectau

Snakebite risk mapping in Rajasthan, India

10/08/2021 – 09/09/2023 (Wrthi'n gweithredu)
KESS II Phd with Bodorgan Est BUK2E024

01/04/2020 – 31/12/2023 (Wrthi'n gweithredu)
Biodiversity Informatics and Technology Exchange for Snakebite Management

15/12/2013 – 01/08/2019 (Wedi gorffen)

Disgrifiad

India has the globally highest annual death rate from venomous snake bites and in some states it is the largest contributor to mortality, exceeding even AIDS and malaria. Data on snakebite is significantly lacking from the north-eastern and Himalayan belt States, where the “Big Four” medically significant venomous snakes are replaced by different sets of venomous snakes. This has serious consequences for the ability to treat cases of snakebite.
Clinical management of snakebites requires timely administration of antivenom (referred to in India as anti-snake-venom serum, or ASVS), neutralizing the life-threatening toxins in snake venom. However, venom composition varies both between and within species, and so the design and production of efficient antivenins depends on thorough understanding of venomous snake diversity and distribution. The resulting biological information and standards from this project will contribute to improving the outcome of snakebite and provide a baseline for future work.
This project is funded by the European Union Seventh Framework Programme under the grant agreement number PIRSES-GA-2013-612131, with additional funding from the Bangor University ESRC Impact Acceleration Account.
Cysylltau:
- http://bites.bangor.ac.uk
Molecular Systematics And Morph Evolutio

31/07/2007 – 08/12/2009 (Wedi gorffen)