Module MSE-2027:
Cell and Molecular Pathology

Module Facts

Run by School of Medical Sciences

20 Credits or 10 ECTS Credits

Semester 1 & 2

Organiser: Dr Dylan Jones

Overall aims and purpose

This module is designed to give an overview of cellular and molecular pathology. It will provide a theoretical and practical insight into investigative methods including imaging, histochemical, immunohistochemical and molecular. It will provide an opportunity to become familiar with the appearance of a number of different types of tissues, organs, and systems and the role of cellular pathology in patient management.

Please note This module is a core component of the School of Medical Sciences accredited Biomedical Sciences degree program. As such students without appropriate pre-requisite background knowledge and understanding of human physiology, anatomy, and cellular biology may find the module content and assessments challenging.

To enhance learning and understanding, lectures are recorded using the Panopto system

Course content

Lectures: Students will undertake studies in both classic cellular pathology techniques such as sample preparation and staining and the role they play in aiding our understanding of tissue structure and function. Students will then cover modern methodologies in use in routine pathology diagnosis such as molecular diagnostics with focus on immunohistochemistry, nucleic acid amplification and hybridisation techniques.

Practical: The Practical will provide hands-on experience in the generation and interpretation of data derived from molecular pathology skills.

Tutorial Each semester will conclude with a tutorial to prepare for the end of semester exam.

Assessment Criteria

excellent

Category A (70%-100%):

Completed assessments present very accurate relevant taught material, integrated with numerous directed outside core text-reading and some self-researched information sources. Essays, answers, and reports present very coherent and well-organised arguments that demonstrate excellent overall knowledge and understanding of all module material.

Evidence of in-depth critical thinking and wider reading are important for grades of A+ and above

threshold

Category D (40%-49%):

A threshold student should have a basic knowledge of the essential facts and key concepts presented in this module. Written answers should demonstrate an ability to organise relevant lecture material into a coherent argument. The answer may contain errors and knowledge gaps.

C- to C+

Category C (50%-59%):

Completed assessments present relevant accurate taught material but may lack explanation and context. Statements are largely correct but not further supported. Essays, answers, and reports are sufficiently coherent and well presented to demonstrate a sound understanding of module material.

good

Completed assessments present overall good accurate relevant taught material, integrated with some directed core text outside-reading. Essays, answers, and reports are well organised and structured, contain good coherent arguments, and demonstrate good overall knowledge and understanding of all module material.

Learning outcomes

  1. Microscopically identify the cell and tissue types found in normal routine stained tissue sections.

  2. Compare and contrast the roles of the common histological and histochemical methods for preparing mammalian cells and tissues for microscopical study in cellular pathology.

  3. Develop practical molecular pathology skills.

  4. Evaluate the role of molecular pathology methods in pathology.

  5. Evaluate the processes involved in the preparation of tissue sections and explain the purpose of each of these processes.

  6. Evaluate the role of cellular pathology in patient management.

Assessment Methods

Type Name Description Weight
EXAM End of Semester 1 Exam

A 1 hour MCQ exam on the semester's work.

25
EXAM End of Semester 2 exam

A 1 hour MCQ exam on the semester's work.

25
ESSAY Essay

An essay reflecting on the role of cellular pathology in patient management.

25
REPORT Molecular Pathology Practical

A report based on the molecular pathology practical reflecting on the different case studies examined during the session.

25

Teaching and Learning Strategy

Hours
Private study

Self-directed background reading, data analysis and processing, assessment and examination preparation

161
Lecture

The core of the module consists of 8 lectures per semester.

Lectures may convey substantial elements of the subject content, provide core themes and explanations of difficult concepts, as well as set the scene for and inspire students' independent learning. Lectures encourage and enable students to develop skills in listening and selective note-taking, to appreciate how information is structured and presented, and to understand the means by which scientific information is obtained. Where appropriate, lectures include reference to experimental evidence and arguments for and against specific hypotheses. The traditional format may be enhanced through the use of computer-based or other learning aids and interactive student participation in groups or by communication networks.

32
Tutorial

1 x 2-hour tutorial session per semester to prepare for exams.

4
Practical classes and workshops

Laboratory classes support learning. They illustrate scientific approaches to discovery, provide opportunities for acquisition of subject-specific technical and transferable skills and reinforce the taught curriculum. This may be associated with appropriate methods to deal with data handling and statistics.

Another objective is to help students to consolidate, deepen and extend the knowledge and understanding that they have previously acquired. Above all, such classes train students in the practical skills and competencies required of their chosen subject area.

3

Transferable skills

  • Literacy - Proficiency in reading and writing through a variety of media
  • Numeracy - Proficiency in using numbers at appropriate levels of accuracy
  • Computer Literacy - Proficiency in using a varied range of computer software
  • Self-Management - Able to work unsupervised in an efficient, punctual and structured manner. To examine the outcomes of tasks and events, and judge levels of quality and importance
  • Exploring - Able to investigate, research and consider alternatives
  • Information retrieval - Able to access different and multiple sources of information
  • Inter-personal - Able to question, actively listen, examine given answers and interact sensitevely with others
  • Critical analysis & Problem Solving - Able to deconstruct and analyse problems or complex situations. To find solutions to problems through analyses and exploration of all possibilities using appropriate methods, rescources and creativity.
  • Safety-Consciousness - Having an awareness of your immediate environment, and confidence in adhering to health and safety regulations
  • Presentation - Able to clearly present information and explanations to an audience. Through the written or oral mode of communication accurately and concisely.
  • Teamwork - Able to constructively cooperate with others on a common task, and/or be part of a day-to-day working team

Subject specific skills

Biomedical Science benchmarks:

The programme aims to give students a comprehension of scientific investigation of Cellular Pathology. (benchmarks: 5.1; 5.3; 5.5)

On successful completion of the course, students will be able to engage with essential facts, major concepts, principles and theories associated with Cellular Pathology, and understand the biological mechanisms underlying human pathological conditions and the basis of the analytical techniques used to diagnose and monitor these conditions. (benchmark: 6.4)

Biomedical Science benchmarks:

The programme aims to give students a comprehension of scientific investigation of Cellular Pathology and Molecular Pathology. (benchmarks: 5.1; 5.3; 5.5)

On successful completion of the course, students will be able to engage with essential facts, major concepts, principles and theories associated with cell and molecular pathology, and understand the biological mechanisms underlying human pathological conditions and the basis of the analytical techniques used to diagnose and monitor these conditions. (benchmark: 6.4)

Be able to undertake practical investigations in a responsible, safe and ethical manner while paying attention to risk assessment, relevant health and safety regulations, ethical issues, procedures for obtaining ethical permission and informed consent and issues relating to patient welfare. (benchmark: 4.3)

Graduates will be able to apply their knowledge to a professional, evidence-based approach to research into the pathogenesis and origins of disease processes. (benchmark: 6.2)

Biomedical science graduates are aware of the current laboratory methods to investigate and diagnose human diseases in clinical and research environments. This includes an appreciation of research and the development of new technologies. (benchmark: 6.3)

Biomedical sciences graduates should recognise and apply subject-specific theories, paradigms, concepts or principles to reach evidence-based decisions. (benchmark: 4.2)

To be able to receive and respond to a variety of sources of information (textual, numerical, verbal, graphical), carry out sample selection, produce record scientific records & analyse data within a statistical context (an understanding of statistical significance and statistical power), and to communicate the outcomes to a variety of audiences using a range of formats, media and approaches including the avoidance of plagiarism. (benchmark: 4.4; 4.5)

Graduates should develop the skills necessary for self-managed and lifelong learning, have an appreciation for the role and impact of intellectual property, and identify and work towards targets for personal, academic, professional and career development. (benchmark: 4.7)

Graduates will be able to apply their knowledge to a professional, evidence-based approach to research into the pathogenesis and origins of disease processes. (benchmark: 6.2)

Biomedical science graduates are aware of the current laboratory methods to investigate and diagnose human diseases in clinical and research environments. This includes an appreciation of research and the development of new technologies. (benchmark: 6.3)

Biomedical sciences graduates should recognise and apply subject-specific theories, paradigms, concepts or principles to reach evidence-based decisions. (benchmark: 4.2)

To be able to receive and respond to a variety of sources of information (textual, numerical, verbal, graphical), carry out sample selection, produce record scientific records & analyse data within a statistical context (an understanding of statistical significance and statistical power), and to communicate the outcomes to a variety of audiences using a range of formats, media and approaches including the avoidance of plagiarism. (benchmark: 4.4; 4.5)

Graduates should develop the skills necessary for self-managed and lifelong learning, have an appreciation for the role and impact of intellectual property, and identify and work towards targets for personal, academic, professional and career development. (benchmark: 4.7)

Resources

Pre- and Co-requisite Modules