Overview

Topics included in the lecture and tutorial series

The module discusses three key areas of the human immune system and the roles of immunology in human disease and research:

• The development of the human immune system and the nature of human immune responses
• The development and nature of Autoimmunity and Autoimmune Diseases, with specific focus on Systemic Lupus Erythematosus (SLE).
• The roles of the human immune system in cancer development and current anti-cancer Immunotherapies

Lectures and tutorials will present summaries of core chapters of the module reference text books and selected cutting edge research papers, research and review papers.

• Innate Immunity: The First Line of Defense and innate induced Responses
• Antigen Recognition by B-cell and T-cell receptors
• The Generation of B-cell and T-cell receptors, 'education' of adaptive Lymphocytes and the nature of self-Tolerance
• Antigen Presentation to T Lymphocytes
• Signaling Through Immune System Receptors
• T Cell-Mediated Immunity
• B Cell-Mediated Immunity
• The Dynamics of Adaptive Immune responses
• Failures in immunity, Autoimmunity and Autoimmune disease
• Cancer and the human immune system, immunotherapy

This module is available to International exchange students of The College of Human Sciences

To enhance learning and understanding, lectures, tutorials and practical demonstrations are recorded for revision using the Panopto system

Assessment Strategy

-threshold -Pass (C- to C+) (range 50-59%)Primary criteria A threshold student demonstrates knowledge of key areas & principles, and understands the main elements of the subject area, although gaps and weaknesses in the argument are evident. No evidence of background study and wider reading. Answer focussed on question but also with some irrelevant material and weaknesses in structure & argument. Answers have several factual/computational errors. No original interpretation. No links between topics are described. Limited problem solving skills. Some weaknesses in presentation accuracy & delivery.Secondary CriteriaC+ Good within the class - Exceeds expectations for some primary criteria - Strong factual knowledge with some weaknesses in understanding - Ideas/arguments are limited but are well presented C Mid-level - Matches all primary criteria - Moderate factual knowledge with some weaknesses in understanding - Ideas/arguments are limited presented with weaknesses in logic/presentation C- Meets requirements of class - Matches most but not all primary criteria - Moderate factual knowledge with several weaknesses in understanding - Ideas/arguments are limited presented with weaknesses in logic/presentation -good -Merit (B- to B+) (range 60-69%)Primary criteria Good students demonstrate strong knowledge & understanding of most but not all of the subject area. Limited evidence of background study. The answer is focussed with good structure. Arguments are presented coherently, mostly free of factual/computational errors. Some limited original interpretation. Well know links between topics are described. Problems are addressed by existing methods/approaches. Good presentation with accurate communicationSecondary CriteriaB+ Good - Exceeds expectations for most primary criteria - Command of subject but with gaps in knowledge - Some ideas/arguments originalB Mid-level - Meets all primary criteria - Strong factual knowledge and understanding - Ideas/arguments are well presented by few are originalB- Meets requirements of class- Meets most but not all primary criteria- Strong factual knowledge with minor weaknesses in understanding- Most but not all ideas/arguments are well presented and few are original -excellent -Distinction (A- to A) (range 70-100%)Primary criteria Excellent students demonstrate comprehensive knowledge & detailed understanding of the subject area. Clear evidence of extensive background study & original thinking. Highly focussed answers and well structured. Arguments are logically presented and defended with evidence and examples. No factual/computational errors. Original interpretation of the information with clear evidence of wider reading. New links between topics are developed and new approaches to a problem are presented. Excellent presentation skills with very accurate communication.Secondary Criteria*A Outstanding - Exceeds expectations for most primary criteria - Complete command of subject and other relevantareas - Ideas/arguments are highly originalA+ Excellent - Exceeds expectations for some primary criteria - Complete command of subject - Ideas/arguments are highly originalA Good - Meets all primary criteria - Command of subject but with minor gaps in knowledgeareas - Ideas/arguments are mostly originalA- Meets requirements of Class - Meets most but not all primary criteria - Complete command of subject but with some gaps in knowledge- Ideas/arguments are mostly original

Learning Outcomes

• Demonstrate in-depth knowledge and understanding of immunology in medical research.

• Demonstrate in-depth knowledge and understanding of the development of the human immune system

• Demonstrate in-depth knowledge and understanding of the roles of the human immune system, in Autoimmune disease and Cancer