Rhedir gan School of Medical Sciences

10.000 Credyd neu 5.000 Credyd ECTS

Semester 1

Trefnydd: Dr David Pryce

This module is designed to deliver an overview of the key molecular, cellular and clinical aspects of the human immune system and immunological responses. Students will be provided with the opportunity to develop introductory knowledge and understanding of the genetics, molecular, cellular and clinical aspects of human immunology in control of infectious and 'non-infectious' diseases; such as autoimmune diseases and cancer.

This module is available to International exchange students of The College of Human Sciences

Please note This module is a core module of the School of Medical Sciences accredited Biomedical Sciences degree programs. As such students without appropriate pre-requisite background knowledge and understanding of human molecular and cellular biology may find the module content and assessments, challenging.

To enhance learning and understanding, lectures, tutorials and practical demonstrations are recorded using the Panopto system

The module covers three main areas of human immunology:

• Development of the human immune system and the nature of human immune responses
• Autoimmunity and Autoimmune Diseases, with focus on Systemic Lupus Erythematosus (SLE).
• The immune system in cancer development and current Cancer Immunotherapies

Lectures and tutorials will present summaries of core chapters of the module reference text book and directed reading to key cutting edge review papers. The module will conclude with a discussion of the development and use of 'immunotherapies' for cutting-edge clinical treatments.

• Basic Concepts in Immunology
• Innate Immunity and induced Responses of Innate Immunity
• Antigen Recognition by B-cell and T-cell receptors
• The Generation of Lymphocyte Antigen Receptors
• Antigen Presentation to T Lymphocytes
• Signaling Through Immune System Receptors
• The Development and Survival of Lymphocytes
• T Cell-Mediated Immunity
• The Humoral Immune Response
• Dynamics of Adaptive Immunity
• Failures of Host Defense Mechanisms
• Autoimmunity
• Manipulation of the Immune Response, via immunotherapy

Practical: The Practical will provide experience in the generation, analysis and interpretation of data derived from ELISA analysis of blood serum samples derived from a patient diagnosed with the autoimmune disease Systemic Lupus Erythematosus (SLE).

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Category A (70%-100%):

Completed assessments present very accurate relevant taught material, integrated with numerous directed outside core text-reading and some self-researched information sources. Essays, answers and reports present very coherent and well organised arguments that demonstrate excellent overall knowledge and understanding of all module material. Evidence of in depth critical thinking and wider reading are important for grades of A+ and above

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Category B (60%-69%):

Completed assessments present overall good accurate relevant taught material, integrated with some directed core text outside-reading. Essays, answers and reports are well organised and structured, contain good coherent arguments, and demonstrate good overall knowledge and understanding of all module material.

C- i C+

Category C (50%-59%):

Completed assessments present relevant accurate taught material but may lack explanation and context. Statements are largely correct but not further supported. Essays, answers and reports are sufficiently coherent and well presented to demonstrate a sound understanding of module material.

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Category D (40-49%):

Completed assessments present sufficient relevant accurate taught material to satisfy the learning outcomes of the module. Essays, answers and reports are sufficiently coherent and well presented to demonstrate threshold level 5 knowledge and understanding of module material.

1. Demonstrate knowledge and understanding of the roles of the human immune system in cancer regulation and cancer immunotherapies

2. Demonstrate knowledge and understanding of the development, regulation and effectiveness of the human innate and adaptive immune system in human health

3. Demonstrate knowledge and understanding of the nature of Autoimmune disease and the use of immunoassays in diagnosis and prognosis of a clinically relevant autoimmune disease

Math	Enw	Disgrifiad	Pwysau
ADDRODDIAD	Practical Report	Full guidance on Report is available via the module Evernote site - click to view	50.00
ARHOLIAD	End of Module Exam	The end of module exam will take place during the end of semester 1 examinations period. The exam will consist of completing one essay answer, from a choice of 3 questions provided. All questions have equal weighting. Questions will focus on module Learning outcomes 1 and 2 Demonstrate knowledge and understanding of the roles of the human immune system in cancer regulation and cancer immunotherapies Demonstrate knowledge and understanding of the development, regulation and effectiveness of the human innate and adaptive immune system in human health Answers should be approximately 1500 words, excluding figures and essay plan. This equates to approximately 2-to-3 pages of a standard answer book. Answers should include a structured short 'essay plan' (worth 20% of final grade), consisting of a bullet pointed list of key concepts and sub-sections titles. Self created figures, diagrams and/or tables can be included, but must be accompanied with explanative text and referred to in main text. An estimated 12.5 hours of notional effort is assigned to the examination assessment.	50.00

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Tutorial	Tutorials will have two formats. Firstly, a 1hr class formative tutorial/assessment, consisting of MCQ style questions and example study methods for enhanced development of 'model' short essay answers Secondly, a timetabled opportunity for students to discuss any area of the module with the module organiser. Topics can include any aspect of the lectures and/or self-researched outside reading	2
Lecture	7 x 2hr Lectures, one per week	14
Private study	Self-directed background reading, data analysis and processing and assessment preparation	81
Practical classes and workshops	1 x 3hr Practical: Use of ELISA in Clinical diagnosis/prognosis of autoimmune disease	3

• Llythrennedd - Medrusrwydd mewn darllen ac ysgrifennu drwy amrywiaeth o gyfryngau
• Rhifedd - Medrusrwydd wrth ddefnyddio rhifau ar lefelau priodol o gywirdeb
• Hunanreolaeth - Gallu gweithio mewn ffordd effeithlon, prydlon a threfnus. Gallu edrych ar ganlyniadau tasgau a digwyddiadau, a barnu lefelau o ansawdd a phwysigrwydd
• Archwilio - Gallu ymchwilio ac ystyried dewisiadau eraill
• Adalw gwybodaeth - Gallu mynd at wahanol ac amrywiol ffynonellau gwybodaeth
• Sgiliau Rhyngbersonol - Gallu gofyn cwestiynau, gwrando'n astud ar atebion a'u harchwilio
• Dadansoddi Beirniadol & Datrys Problem - Gallu dadelfennu a dadansoddi problemau neu sefyllfaoedd cymhleth. Gallu canfod atebion i broblemau drwy ddadansoddiadau ac archwilio posibiliadau
• Cyflwyniad - Gallu cyflwyno gwybodaeth ac esboniadau yn glir i gynulleidfa. Trwy gyfryngau ysgrifenedig neu ar lafar yn glir a hyderus.
• Gwaith Tîm - Gallu cydweithio'n adeiladol ag eraill ar dasg gyffredin, ac/neu fod yn rhan o dîm gweithio o ddydd i ddydd
• Dadl - Gallu cyflwyno, trafod a chyfiawnhau barn neu lwybr gweithredu, naill ai gydag unigolyn neu mewn grwˆp ehangach
• Hunanymwybyddiaeth & Ystyried - Bod yn ymwybodol o'ch cryfderau, gwendidau, nodau ac amcanion eich hun. Gallu adolygu ,cloriannu a myfyrio'n rheolaidd ar eich perfformiad eich hun ac eraill.

• Understand the development of the human innate and adaptive immune systems and nature of human immune responses to pathogens
• Ability to utilise the enzyme linked immunosorbant assay (ELISA) for detection of human autoantibody concentrations and ability to analyse data for use in human autoimmune disease prognosis
• Understand current theories of the role of human immune system in cancer progression and the roles of immunotherapies in cancer treatment

Rhestrau Darllen Bangor (Talis)

http://readinglists.bangor.ac.uk/modules/mse-2014.html

Opsiynol mewn cyrsiau:

• C100: BSC Biology year 2 (BSC/B)
• C511: BSc Biology with Biotechnology year 2 (BSC/BIOT)
• C102: BSc Biology (with International Experience) year 2 (BSC/BITE)
• C101: MBiol Master of Biology year 2 (MBIOL/BIO)
• C510: MBiol Biology with Biotechnology year 2 (MBIOL/BIOT)