Rhedir gan School of Natural Sciences

10.000 Credydau neu 5.000 Credyd ECTS

Semester2

Trefnydd: Dr Martina Lahmann

The module aims to introduce the student to advanced specialised topics of inorganic reaction mechanisms and organic synthesis.

This module covers inorganic reaction mechanisms and advanced organic synthesis with focus on asymmetric synthesis.

Keyword list (inorganic chemistry): Reaction Mechanisms. Classification of inorganic reaction mechanisms. What is a reaction mechanism? How are reaction mechanism studied? Kinetics. Reaction profiles for A, Ia Id and D mechanisms. Substitution at 4-coordinate transition-metal sites: Tetrahedral - Co-ordinatively saturated complexes (D mechanism); unsaturated complexes (A mechanism); competing mechanisms and temperature effects. Square-planar - Associative mechanisms and the role of solvent; evidence for a solvent intermediate; stereochemistry of substitution; influence of entering group (nucleophilicity scales); influence of spectator ligand (trans effect); influence of leaving group; dissociative mechanisms at square planar sites. Substitution at six-coordinate octahedral sites: role of solvent; the solvolysis reaction (leaving group; spectator ligands and stereochemistry); displacement of coordinated solvent (solvent exchange, inert/labile, CFAE, Eigen-Wilkins Id mechanism). Direct substitution without solvent interaction. Base catalysed hydrolysis (Dcb mechanism, tbp intermediate); acid catalysed hydrolysis; redox catalysed substitution. Electron-transfer reactions; classification of reactions: stoichiometry (complementary and noncomplementary reactions), mechanism (inner sphere and outer sphere); differentiation between inner and outer sphere reactions. Outer sphere reactions: self-exchange reactions and Marcus cross theory.

Organic section: This section of the module will revise and expand core concepts of selectivity and specificity, kinetic vs. thermodynamic control, regio- and stereo- control. Also, strategies and challenges in ring formation will be discussed. The material will be illustrated with examples of total synthesis, examined both from the synthetic, retrosynthetic and mechanistic perspective. A particular emphasis will be on diastereoselective and asymmetric synthesis (resolution, asymmetric induction, chiral auxiliary, chiral pool, organo catalysis, bio catalysis, asymmetric catalysis) in the view of both research and industrial applications.

Course Team: Dr M Beckett (12 lectures), Dr M Lahmann (12 lectures)

RESOURCE IMPLICATIONS ESSENTIAL READING 1. Inorganic Chemistry, 3rd Ed., C E Housecroft & A G Sharpe (Prentice Hall), 2008. 2. Organic Chemistry Jonathan Clayden, Nick Greeves, Stuart Warren and Peter Wothers (2nd Ed 2012) RECOMMENDED READING 1..Advanced Inorganic Chemistry, 5th Ed., Cotton & Wilkinson (Wiley) SPECIFIC RESOURCE IMPLICATIONS FOR STUDENTS - None

trothwy

Threshold (40%). Knowledge and understanding of the content covered in the course is basic; Problems of a routine nature are generally adequately solved; Transferable skills are at a basic level.

dda

Good (~60%). Knowledge base covers all essential aspects of subject matter dealt with in the programme and shows good evidence of enquiry beyond this. Conceptual understanding is good. Problems of a familiar and unfamiliar nature are solved in a logical manner; solutions are generally correct and acceptable. Performance in transferable skills is sound and shows no significant deficiencies.

rhagorol

Excellent (>70%). Knowledge base is extensive and extends well beyond the work covered in the programme. Conceptual understanding is outstanding. Problems of a familiar and unfamiliar nature are solved with efficiency and accuracy; problem-solving procedures are adjusted to the nature of the problem. Performance in transferable skills is generally very good

1. Students will be able to recognize and retrosynthetically analyse a target molecule and be able to plan an effective synthetic approach.

2. Students will be able to understand the roles of reagents used in synthesis.

3. Students will be able to have a fundamental understanding how to control reaction processes in terms of selectivity.

4. Students will be able to understand the various methods for asymmetric synthesis and to link them to worked examples.

5. Students will be able to accomplish worked examples in synthesis.

6. Students will be able to demonstrate factual knowledge of substitution and electron transfer reaction mechanisms of transition metal complexes.

7. Students will be able to understand the factors which affect the rates of substitution and electron transfer reactions of transition metal complexes.

8. Students will be able to understand experimental reaction rates in terms of reaction mechanisms.

Math	Enw	Disgrifiad	Pwysau
	Examination		100.00

		Oriau
Lecture		22
Private study		76
Tutorial		2

• Literacy - Proficiency in reading and writing through a variety of media
• Numeracy - Proficiency in using numbers at appropriate levels of accuracy

• CC4 The ability to recognise and analyse problems and plan strategies for their solution
• PS3 Problem-solving skills, relating to qualitative and quantitative information
• PS4 Numeracy and mathematical skills, including handling data, algebra, functions, trigonometry, calculus, vectors and complex numbers, alongside error analysis, order-of-magnitude estimations, systematic use of scientific units and different types of data presentation
• SK2 Demonstrate a systematic understanding of fundamental physicochemical principles with the ability to apply that knowledge to the solution of theoretical and practical problems
• SK3 Gain knowledge of a range of inorganic and organic materials
• PS16 The ability to work in multi-disciplinary and multi-skilled teams
• SK9 Read and engage with scientific literature
• CC1 the ability to demonstrate knowledge and understanding of essential facts,concepts,principles and theories relating to theSubject areasCovered in theirProgramme
• CC2 the ability to applysuch knowledge and understanding to thesolution of qualitative and quantitativeProblems that are mostly of a familiar nature

Cydofynnol ar gyfer:

• FXX-3505: Organomet Chem & Catalysis

Gorfodol mewn cyrsiau:

• F100: BSC Chemistry year 3 (BSC/C)
• F102: Chem with Europ Exper year 4 (BSC/CEE)
• F105: BSc Chemistry with International Experience year 4 (BSC/CHIE)
• F103: BSC Chem with Ind Exper year 4 (BSC/CIE)
• F104: MChem Chemistry year 3 (MCHEM/CH)
• F106: MChem Chemistry with International Experience year 4 (MCHEM/CHIE)
• F101: MChem Chemistry with Industrial Experience year 4 (MCHEM/CIND)